Metastatic Carcinoid Disease Presenting Solely as High-Output Heart Failure

D, Yun; Jt, Heywood

doi:10.7326/0003-4819-120-1-199401010-00008

Cited by 3 publications

(1 citation statement)

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“…A) High output failure due to excess neurohormonal activation has been reported [60]. High output failure can be a manifestation of pellagra, which can occur because of diversion of the body's tryptophan stores from the production of niacin [61].…”

Section: Rarer Manifestations Of Carcinoid Heart Disease Without Valv...mentioning

confidence: 99%

Carcinoid Heart Disease – A Review of Pathophysiology, Clinical Manifestations, Diagnosis and Management

Ghanta¹,

Vallurupalli²

2023

CVIA

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Objective: Neuro-endocrine tumors (NET) resulting in syndromes of serotonin excess can lead to cardiac involvement, and substantial mortality and morbidity. This article is aimed at reviewing the pathophysiology, diagnosis and management of carcinoid heart disease (CHD). Results: The pathophysiology of CHD stems from chronic exposure to circulating vasoactive compounds. Frequent clinical evaluations, monitoring of biomarker levels and cardiac imaging play critical roles in screening and early recognition. The complexity of the disease necessitates a multidisciplinary approach, medical management and timely surgical intervention. Conclusion: Outcomes of CHD have improved, owing to advances in medical management and increased surgical expertise. Surgical valvular intervention is the only definitive therapy for the treatment of symptomatic CHD.

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Section: Rarer Manifestations Of Carcinoid Heart Disease Without Valv...mentioning

confidence: 99%

Carcinoid Heart Disease – A Review of Pathophysiology, Clinical Manifestations, Diagnosis and Management

Ghanta¹,

Vallurupalli²

2023

CVIA

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Cardiac Complications

Ewer

Suter

2017

Holland‐Frei Cancer Medicine

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Overview Patients with malignant diseases often have coexisting cardiovascular disorders or may face serious cardiovascular complications in the course of their disease. The disorders may result from underlying conditions such as atherosclerosis, hypertension, or valvular abnormalities, or they may result directly from cancer or its treatment (Table 1). In addition, cardiovascular disorders that are unusual in patients not afflicted with cancer may be more common in the cancer patient and sometimes are unsuspected. Furthermore, cardiovascular diseases common in the general population must not be overlooked in patients with cancer; the presentation of such entities may be unusual, and the diagnosis often is more complex. Increased clinical scrutiny is therefore necessary in this vulnerable population. Multiple clinical problems may also coexist and defy a simple illumination because of the complex interactions between the malignancy, its treatment, and the cardiovascular system; what affects one often alters the presentation and course of the others. This chapter will look at some of the more common cardiovascular complications of cancer and its treatment, and will also address some of the dilemmas encountered in cancer patients with concomitant cardiac conditions.

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Cardiac Complications

Ewer¹,

Ewer²,

Suter³

2022

Holland‐Frei Cancer Medicine

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Overview Patients with malignant diseases often have coexisting cardiovascular disorders or may face serious cardiovascular complications in the course of their disease. 1 The disorders may result from underlying conditions such as atherosclerosis, hypertension, or valvular abnormalities, or they may result directly from cancer or its treatment (Table 1). In addition, cardiovascular disorders that are unusual in patients not afflicted with cancer may be more common in the cancer patient, and sometimes are unsuspected. Furthermore, cardiovascular diseases common in the general population must not be overlooked in patients with cancer; the presentation of such entities may be unusual, and the diagnosis often is more complex. Increased clinical scrutiny is therefore necessary in this vulnerable population. Multiple clinical problems may also coexist and defy a simple illumination because of the complex interactions between the malignancy, consequences of its treatment, and the status of the cardiovascular system; what affects one of these variables often alters the presentation and course of the others. This article will look at some of the more common cardiovascular complications of cancer and its treatment and will also address some of the dilemmas encountered in cancer patients with concomitant cardiac conditions.

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Metastatic Carcinoid Disease Presenting Solely as High-Output Heart Failure

Cited by 3 publications

References 0 publications

Carcinoid Heart Disease – A Review of Pathophysiology, Clinical Manifestations, Diagnosis and Management

Carcinoid Heart Disease – A Review of Pathophysiology, Clinical Manifestations, Diagnosis and Management

Cardiac Complications

Cardiac Complications

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