Metastatic cancer to the stomach

Campoli, Paulo Moacir de Oliveira; Ejima, Flávio Hayato; Cardoso, Daniela Medeiros Milhomem; Silva, Osterno Queiroz da; Filho, Jales Benevides Santana; Barreto, Paulo; Machado, Márcio Martins; Mota, Eliane Duarte; Filho, João Alves A.; Alencar, Rita de Cássia Gonçalves; Mota, Orlando Milhomem da

doi:10.1007/s10120-005-0352-5

Cited by 72 publications

(65 citation statements)

References 42 publications

(75 reference statements)

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“…Metastatic cancer to the stomach is uncommon, and only four studies have systematically addressed this rare finding [21][22][23][24]. Primary sites most frequently reported include lung and breast cancer, as well as malignant melanoma.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the occurrence of gastric metastasis might serve as an indicator of advanced disease. The outcome of affected patients is generally poor, the median survival being 4.75 months [24].…”

Section: Discussionmentioning

confidence: 99%

“…According to Campoli et al [24] the mean (range) interval between the diagnosis of the primary tumour and diagnosis of the gastric metastasis is 1.3 (0-4.7) years, with half of the patients having gastric tumour recurrence within a year. However, gastric metastasis attributable to RCC occurs after a significantly longer interval; the mean (median, range) time to diagnosis of gastric metastasis in the present cases and those reported previously was 6.5 (4.7, 0.1-20) years.…”

Section: Discussionmentioning

confidence: 99%

“…Comparable to patients with primary gastric cancer, anaemia or gastrointestinal bleeding, dyspepsia and epigastric pain are the clinical symptoms most frequently requiring endoscopy in patients with gastric metastasis [21][22][23][24]. Accordingly, the vast majority of patients with RCC developing gastric metastases showed symptoms of gastrointestinal bleeding, which presented as either melena (14, 64%), microcytic anaemia (10, 45%), or overt upper gastrointestinal haemorrhage (eight, 36%).…”

Section: R C C M E T a S T A T I C T O T H E S T O Mmentioning

confidence: 99%

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Renal cell carcinoma metastatic to the stomach: single‐centre experience and literature review

Pollheimer¹,

Hinterleitner²,

Pollheimer³

et al. 2008

BJU International

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diagnosis of cancer in gastric biopsies or resection specimens. The histopathological slides of both renal and gastric cancer probes, and the clinical presentation, treatment and outcome of affected patients, were reassessed. RESULTSTwelve patients with primary gastric cancer, one with local RCC recurrence affecting the antrum and five with clear cell RCC (three men and two women; mean age 73 years, range 65-83) with haematogenous cancer spread to the stomach were detected. The mean (range) time to gastric metastasis was 6.9 (1.7-13.1) years. There were metastases to other organs, most often the lung, in all patients.

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Section: Discussionmentioning

confidence: 99%

“…Thus, the occurrence of gastric metastasis might serve as an indicator of advanced disease. The outcome of affected patients is generally poor, the median survival being 4.75 months [24].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: R C C M E T a S T A T I C T O T H E S T O Mmentioning

confidence: 99%

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Renal cell carcinoma metastatic to the stomach: single‐centre experience and literature review

Pollheimer¹,

Hinterleitner²,

Pollheimer³

et al. 2008

BJU International

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“…The most frequent location sites of cancer cells are in the body and gastric fundus, and single tumors predominate against multiple. Although generally gastric metastases account for 0.2-0.7% of stomach tumors, the metastatic tumor from carcinoma renal cells is extremely rare (3) and is an event late. The gastric metastases from renal cell carcinoma are diagnosed years after the primary tumor (4).…”

Section: Discussionmentioning

confidence: 99%

Gastric metastasis from renal cancer six years after nephrectomy

Cruz

Ramírez²,

Sánchez

et al. 2011

Rev. esp. enferm. dig.

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Renal cell carcinoma is the third most common urogenital neoplasia (1). The lung and bone tissues represent the most frequent metastatic sites of renal cell carcinoma (2). Metastases in the stomach are rare and have been essentially described during autopsies (3). In this paper, we present a case of large metastatic gastric tumor whose origin was a renal cell carcinoma treated years ago. Case reportA 56 year old woman was diagnosed with stage one renal adenocarcinoma 6 years ago. She was treated with right radical nephrectomy and adjuvant chemotherapy. Three years later was diagnosed and treated of brain metastasis located in the frontal lobe, as well as in lung. A year ago, she came to our hospital for upper gastrointestinal bleeding. She presented acceptable general condition and nutritional, blood pressure 120/70 mmHg and normal cardio-respiratory auscultation. The abdomen was soft, non-tender, and no masses or organ enlargements. The analytical study revealed 6.3 g/dl hemoglobin. A thoracic abdominal TAC showed a large mass in the body and antrum stomach of 11 cm diameter without invasion adjacent structures. An upper gastrointestinal endoscopy revealed a large neoplasm from body to gastric antrum with mamelonated aspect. The patient underwent subtotal gastrectomy. The postoperative course was uneventful. The pathology and immunohistochemical study showed metastasis of kidney carcinoma ( Fig. 1). DiscussionMetastatic gastric cancer is uncommon. The most frequent location sites of cancer cells are in the body and gastric fundus, and single tumors predominate against multiple. Although generally gastric metastases account for 0.2-0.7% of stomach tumors, the metastatic tumor from carcinoma renal cells is extremely rare (3) and is an event late. The gastric metastases from renal cell carcinoma are diagnosed years after the primary tumor (4). The histological diagnoses require immunohistochemical analysis for differential diagnostic. We studied AE1/AE3 and vimentin markers, and the most recent CD10 and renal cell carcinoma markers (RCC-Ma). CD10 is a cell surface enzyme expressed in several types of normal cells including the brush border of renal tubular epithelial cells. Positivity for this marker is seen in more than 90% of renal clear carcinomas (5). RCC-Ma is a monoclonal antibody against a normal renal proximal tubule antigen. RCCMa expression is relatively specific for primary clear cell in renal carcinoma (6). In our case, the markers confirmed the diagnosis of renal carcinoma. The classic vimentin and AE1/AE3 markers were strongly positive, while CD10 and RCC-Ma showed moderately and weakly positive staining, respectively. The treatment of gastric metastases is controversial. The patients have poor prognosis with frequent extragastric metastases, and the treatment is endoscopic therapy and arterial embolization (7,8). The absence of evidence for other metastases and the presence of large tumor did not support the consideration of therapeutic endoscopy. By contrast, subtotal gastrectomy allowed acceptable...

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Epithelial Tumours of the Stomach

Carneiro

Lauwers

2012

Morson and Dawson's Gastrointestinal Pathology

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Metastatic cancer to the stomach

Cited by 72 publications

References 42 publications

Renal cell carcinoma metastatic to the stomach: single‐centre experience and literature review

Renal cell carcinoma metastatic to the stomach: single‐centre experience and literature review

Gastric metastasis from renal cancer six years after nephrectomy

Epithelial Tumours of the Stomach

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