Metastatic breast cancer masquerading as a renal malignancy: A literature review and case report

Gilbert, Brent; Cordova, Leonardo Zandavalli; Eaton, Anthony

doi:10.1016/j.eucr.2019.100859

Cited by 3 publications

(2 citation statements)

References 5 publications

(14 reference statements)

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“…The primary cause of morbidity and death among BC patient is tumor metastasis [9]. The most common sites of BC metastasis include the bone, brain, lungs, and liver [10]; although rare, the tumor can also spread to the extraocular muscle [11] and to the urinogenital regions of the body [12][13][14]. Tumor metastasis is a highly complex and multistep event.…”

Section: Introductionmentioning

confidence: 99%

Adipose Tissue from Lean and Obese Mice Induces a Mesenchymal to Epithelial Transition-Like Effect in Triple Negative Breast Cancers Cells Grown in 3-Dimensional Culture

Asante

Pallegar

Hoffmann

et al. 2020

IJMS

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Breast cancer is the second leading cause of cancer-related mortality among women globally with obesity being one risk factor. Obese breast cancer patients have at least a 30% increased risk of death from breast cancer compared to non-obese breast cancer patients because they present with larger tumors and generally have increased rates of metastasis. Moreover, obese breast cancer patients respond more poorly to treatment compared to non-obese patients, particularly pre-menopausal women diagnosed with triple negative breast cancer (TNBC). To help understand the molecular mechanisms underlying the increased metastasis associated with obesity, we previously established a three-dimensional culture system that permits the co-culture of adipocytes and TNBC cells in a manner that mimics an in vivo milieu. Using this system, we demonstrate that white adipose tissue from both lean and obese mice can induce a partial mesenchymal-to-epithelial transition (MET). Triple negative breast cancer cells adopt an epithelial morphology and have an increased expression of some epithelial markers, but they maintain the expression of mesenchymal markers, furnishing the breast cancer cells with hybrid properties that are associated with more aggressive tumors. Thus, these data suggest that adipose tissue has the potential to promote secondary tumor formation in lean and obese women. Further work is needed to determine if targeting the partial MET induced by adipose tissue could reduce metastasis.

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Section: Introductionmentioning

confidence: 99%

Adipose Tissue from Lean and Obese Mice Induces a Mesenchymal to Epithelial Transition-Like Effect in Triple Negative Breast Cancers Cells Grown in 3-Dimensional Culture

Asante

Pallegar

Hoffmann

et al. 2020

IJMS

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“…Krūties karcinomos metastazavimo į inkstus dažnis išskirtinai mažas. Literatūroje minima tik 15 nepriklausomų atvejų [4]. Pacientui, sergančiam krūties karcinoma, yra maždaug 2-3 proc.…”

Section: Diskusijaunclassified

Krūties Karcinomos Metastazė Šviesialąstelinėje Inksto Ląstelių Karcinomoje: Klinikinis Atvejis

Rudoj¹

2021

Health Sciences

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Navikų metastazavimas į kitus navikus (tumor-to-tumor metastasis /TTM) − labai retas fenomenas. Šiame straipsnyje pristatomas krūties karcinomos metastazavimo į šviesialąstelinę inksto ląstelių karcinomą atvejis. 69 metų pacientei, daugiau nei 10 metų sergančiai krūties karcinoma, įtartas ligos progresavimas į inkstus. Ligos židiniui pašalinti atlikta nefrektomija. Atliekant patologijos tyrimą, inkste nustatyta 4 cm skersmens šviesialąstelinė inksto ląstelių karcinoma, kurioje buvo aptikta 2,9 mm krūties karcinomos metastazė. Krūties karcinoma labai retai metastazuoja į inkstus, literatūroje aprašyta tik 15 tokių atvejų. Krūties karcinomos metastazės į inkstų ląstelių karcinomą yra labiausiai paplitęs naviko metastazių į kitus navikus variantas. Literatūroje aprašyti 9 panašūs atvejai. Straipsnio tikslas − pristatyti retą patologinės diagnostikos atvejį, parodžiusį, jog esant dauginiams navikų židiniams, būtina atlikti jų histologinį ištyrimą. Sinchroninių ir metachroninių navikų ir metastazių atpažinimas daro įtaką pacientų gydymui ir prognozei. Naviko metastazavimo į kitą naviką fenomeno mokslinis tyrimas gali suteikti naujos informacijos apie navikų biologiją, padėti kurti naujus diagnostikos, gydymo ir prevencijos metodus.

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Primary synchronous malignancies of the breast and the kidney

et al. 2021

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Synchronous primary malignancies are most frequently seen with cancers of the stomach and oesophagus, mainly attributed to the similar genetic mutations. Most of these multiple malignancies turn out to be metastatic or metachronous lesions. Multiple synchronous malignancies are rarer than metachronous ones. Primary synchronous breast and renal cancer is even rare. These patients require extensive workup to exclude all possible metastases. The nature of the primary tumours must also be confirmed, prior to any treatment strategy. We report the case of a healthy, middle-aged woman who initially presented with a lesion suspicious for breast carcinoma, and further workup revealed the presence of an asymptomatic, synchronous primary renal cell cancer, which is a very rare presentation.

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Metastatic breast cancer masquerading as a renal malignancy: A literature review and case report

Cited by 3 publications

References 5 publications

Adipose Tissue from Lean and Obese Mice Induces a Mesenchymal to Epithelial Transition-Like Effect in Triple Negative Breast Cancers Cells Grown in 3-Dimensional Culture

Adipose Tissue from Lean and Obese Mice Induces a Mesenchymal to Epithelial Transition-Like Effect in Triple Negative Breast Cancers Cells Grown in 3-Dimensional Culture

Krūties Karcinomos Metastazė Šviesialąstelinėje Inksto Ląstelių Karcinomoje: Klinikinis Atvejis

Primary synchronous malignancies of the breast and the kidney

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