Metastatic brain tumors from non-small cell lung cancer with EGFR mutations: Distinguishing influence of exon 19 deletion on radiographic features

Sekine, Akimasa; Kato, Terufumi; Hagiwara, Eri; Shinohara, Tokuko; Komagata, Takanobu; Iwasawa, Tae; Satoh, Hiroaki; Tamura, Katsumi; Kasamatsu, Tomotaka; Hayashihara, Kenji; Saito, Takefumi; Takahashi, Hiroshi; Ogura, Takashi

doi:10.1016/j.lungcan.2011.12.017

Cited by 92 publications

(70 citation statements)

References 32 publications

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“…For instance, Laack et al 11 described a miliary pattern of pulmonary metastasis strongly associated with EGFR exon 19 deletion in 5 patients. Sekine et al 12 reported that patients with exon 19 deletion were more likely to have multiple and smaller brain metastases. Our study found a significant FIGURE 1 Forest plots showing the univariable and multivariable analyses for overall survival (OS).…”

Section: Discussionmentioning

confidence: 99%

“…One explanation is a predisposition for liver spread in exon 21-mutant disease. An alternative explanation comes from case reports associating exon 19 deletion with a particular pattern of tiny and innumerable metastases in lung and brain resembling a miliary pattern [11][12][13] . A presentation of that kind in the liver would make the metastases more difficult to detect on computed tomography or magnetic resonance imaging 14 and could explain our finding of fewer liver metastases in our exon 19 subgroup.…”

Section: Figurementioning

confidence: 99%

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Patterns of Spread and Prognostic Implications of Lung Cancer Metastasis in an Era of Driver Mutations

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Patterns of Spread and Prognostic Implications of Lung Cancer Metastasis in an Era of Driver Mutations

et al. 2017

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“…Pemetrexed, in combination with cisplatin, has recently been used in the treatment of metastatic NSCLC patients (9)(10)(11). NSCLC patients with the exon 19 deletion have a distinctive pattern of brain metastases which usually present as multiple small metastases with low levels of brain edema (12,13). Certain studies have indicated that gefitinib and erlotinib penetrate into the central nervous system and elicit responses in NSCLC patients with brain metastases (13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Efficacy assessment of pemetrexed treatment of an NSCLC case with brain metastasis

et al. 2012

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Abstract. Non-small cell lung cancers (NSCLCs) are among the most common malignancies. Although pemetrexed is often used clinically to cure cancers, its efficacy in NSCLC patients with progressive brain metastases remains unclear. Here, we report a successful NSCLC (adenocarcinoma) case treated with pemetrexed. The detected tumors were treated with 900 mg of pemetrexed disodium (500 mg/m 2 ) was administered to the patient on day 1, and 40 mg of cisplatin (25mg/m 2 ) was administered on days 1-3, at the interval of 3 weeks. After two cycles of chemotherapy, the brain metastases were reduced. The lesion in the lung was reduced as determined by chest CT-scan. Our results suggest that pemetrexed is an effective therapy for patients with NSCLC and progressive brain metastases.

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“…Previously described as carcinomatosis encephalitis, it is now frequently described with advanced imaging techniques and has been reported in 17 cases across literature in conjunction with lung adenocarcinoma [2]. A retrospective analysis of these cases has depicted an association of miliary pattern with exon 19 deletion (EGFR mutation) [1].…”

Section: Discussionmentioning

confidence: 99%

Rare Presentation of Miliary Brain Metastasis in Absence of TypicallyAssociated Mutation

Kaushalendra¹,

Tripathi²

2017

J Neurol Neurophysiol

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Lung cancer frequently presents with metastasis to the brain. Previously multiple metastases to the brain, described as miliary metastasis, have been reported with lung cancer and more commonly adenocarcinoma subtype. Various gene mutations involving exon 19, exon 20 and exon 21 have been reported with such metastasis. Though the prognosis is poor it is useful to identify such spread in order to tailor the treatment plan for a patient. We present a case of miliary metastasis to the brain in a patient with Grade IVa lung cancer presenting with confusion and speech difficulties.

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Metastatic brain tumors from non-small cell lung cancer with EGFR mutations: Distinguishing influence of exon 19 deletion on radiographic features

Cited by 92 publications

References 32 publications

Patterns of Spread and Prognostic Implications of Lung Cancer Metastasis in an Era of Driver Mutations

Patterns of Spread and Prognostic Implications of Lung Cancer Metastasis in an Era of Driver Mutations

Efficacy assessment of pemetrexed treatment of an NSCLC case with brain metastasis

Rare Presentation of Miliary Brain Metastasis in Absence of TypicallyAssociated Mutation

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