Metastatic angiosarcoma in a bone marrow biopsy

Germans, Sharon Koorse; Weinberg, Olga K.

doi:10.1182/blood.2022018036

Cited by 3 publications

(2 citation statements)

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“…Among mesenchymal tumors, Ewing sarcoma and pediatric rhabdomyosarcoma BMI is not uncommon [24][25]; more rarely, bone marrow infiltration from other histologic subtypes like angiosarcoma [26], epithelioid sarcoma [27] and follicular dendritic cell sarcoma [28] has been reported. Given the aggressiveness of such sarcoma subtypes, most cases were treated with high dose, multidrug regimens with poor responses and severe hematological toxicity, often fatal.…”

Section: Discussionmentioning

confidence: 99%

High-dose continuous infusion ifosfamide in the treatment of bone marrow infiltration with severe thrombocytopenia in a patient with Ewing sarcoma: a case report

Murtas,

Chiusole,

Tortorelli

et al. 2024

Preprint

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Ewing sarcoma is a rare primary mesenchymal tumor of the bone that requires an intensive multimodal therapeutic approach. Multidrug chemotherapy regimens are also the backbone for relapsing/recurring Ewing sarcoma treatment, yet when relapse occurs as bone marrow infiltration, combination chemotherapy might be difficult to be administered and prognosis is poor. This report describes the case of a 22-year-old patient with Ewing sarcoma who developed severe pancytopenia due to bone marrow infiltration, who was treated with high-dose continuous infusion ifosfamide, obtaining both clinical, radiological and hematological response lasting for about 7 months.

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Section: Discussionmentioning

confidence: 99%

High-dose continuous infusion ifosfamide in the treatment of bone marrow infiltration with severe thrombocytopenia in a patient with Ewing sarcoma: a case report

Murtas,

Chiusole,

Tortorelli

et al. 2024

Preprint

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“…The prognosis of angiosarcomas is notably poor ( 19 ), with frequent occurrences of both local recurrence and distant metastasis ( 31 , 32 ), typically resulting in a reported 5-year survival rate of approximately 31–33% ( 8 , 33 ). Angiosarcoma manifesting in bone exhibits a significantly bleaker prognosis compared to general angiosarcoma, with a 5-year survival rate of 20% and an approximate median survival time of 10 months ( 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: A rare case of multicentric angiosarcomas of bone mimicking multiple myeloma on 18F-FDG PET/CT

Huang,

Xiao,

Zhang

et al. 2023

Front. Med.

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BackgroundAngiosarcoma, a rare endothelial-origin tumor, can develop throughout the body, with the head and neck skin being the most commonly affected areas. It can also originate in other sites such as the breast, iliac artery, and visceral organs including the liver, spleen, and kidneys. Angiosarcoma of the bone is remarkably rare, presenting as either unifocal or multifocal bone lesions and often leading to a grim prognosis. Diagnosing bone angiosarcoma poses a significant challenge. 18F-FDG PET/CT serves as a reliable and indispensable imaging modality for evaluating distant metastases and clinically staging angiosarcomas.Case reportA 57-year-old woman presented with a 10-day history of dizziness and headaches. Cranial CT scan revealed bone destruction of the parietal bone, accompanied by soft tissue lesions, protruding into the epidural space. MRI examination demonstrated lesions with slightly elevated signal intensity on T2FLAIR, showing moderate enhancement. Furthermore, multiple foci were observed within the T12, L1-5, and S1-2 vertebrae, as well as in the bilateral iliac bones. For staging, 18F-FDG PET/CT was performed. The MIP PET showed multifocal FDG-avid lesions in the sternum, bilateral clavicles, bilateral scapulae, multiple ribs, and pelvic bones. Heterogeneous FDG uptake was observed in multiple bone lesions, including intracranial (SUVmax = 11.3), right transverse process of the T10 vertebra (SUVmax = 5.8), ilium (SUVmax = 3.3), and pubis (SUVmax = 4.7). The patient underwent surgical resection of the cranial lesion. The pathological diagnosis was made with a highly differentiated angiosarcoma.ConclusionAngiosarcoma of bone on FDG PET/CT scans is characterized by abnormal FDG uptake along with osteolytic destruction. This case highlights that angiosarcoma of bone can manifest as multicentric FDG uptake, resembling the pattern seen in multiple myeloma. FDG PET/CT can be a useful tool for staging this rare malignant tumor, offering the potential to guide biopsy procedures toward the most metabolically active site. And it should be considered in the differential diagnosis of multiple osteolytic lesions, including metastatic carcinoma, multiple myeloma, and lymphoma of bone.

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Here is the metastasis - find the primary carcinoma for it: a large biopsy study

Özdemir

Şenol

Baykara

et al. 2023

The European Research Journal

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Objectives: According to estimates, cancer of unknown primary origin (CUP) accounts for approximately 3 to 5% of new cancer cases annually in the United States. With early diagnosis, many CUP patients can achieve long-term remission. The aim of this study was to document the organ tropism for metastasis for tumors with a definite primary cancer. In addition, we sought to contribute to understanding organ tropism in tumors of unknown origin. Methods: Retrospectively, biopsies of 492 metastatic cancers were evaluated. The required immunohistochemical panel was applied to determine the tumors’ origins. Results: A total of 492 patients with metastases were included in the study. The most common origins of metastasizing tumors were lung (25.4%), colon (18.9%), breast (15.4%) and stomach cancers (10.6%). The least metastatic tumors were the salivary gland, neuroendocrine, adrenal, tubal, nasopharynx, rectum and esophagus cancers (0.22% for all). The most common cancers that metastasized to the liver were colon cancer (29.0%), stomach cancer (18.6%) and pancreatic cancer (18.6%). The most common cancers that metastasized to the bone were lung cancer (58.0%), breast cancer (29.0%), and prostate cancer (13.9%). The most common types of tumors that metastasized to the lungs, the kidney (35.1%), colon (29.7%), and breast cancers (16.2%), were the most common. The most common tumors that metastasized to the brain were the lung (61.1%), the breast (16.7%), and kidney cancers (8.7%). The most common tumors metastasizing to the skin were lung (31.0%), breast (27.6%), and colon (13.8%) cancers. Conclusions: Primary cancers have different metastatic patterns, which may help determine their causes. By involving distant anatomical structures and disrupting their function, tumor metastases increase the morbidity and mortality associated with the disease; thus, they affect staging, prognosis, and treatment. Metastases (or cancers from unknown primary sites) usually require extensive investigation to determine their primary source. Whether the cancer is tracked prospectively or retrospectively, a detailed observational template highlighting expected metastatic patterns would greatly assist in diagnosis and treatment.

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Metastatic angiosarcoma in a bone marrow biopsy

Cited by 3 publications

References 0 publications

High-dose continuous infusion ifosfamide in the treatment of bone marrow infiltration with severe thrombocytopenia in a patient with Ewing sarcoma: a case report

High-dose continuous infusion ifosfamide in the treatment of bone marrow infiltration with severe thrombocytopenia in a patient with Ewing sarcoma: a case report

Case Report: A rare case of multicentric angiosarcomas of bone mimicking multiple myeloma on 18F-FDG PET/CT

Here is the metastasis - find the primary carcinoma for it: a large biopsy study

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