Metastatic Adrenal Cortical Carcinoma Responding to Octreotide: A Case Report

Abstract

Advanced adrenocortical carcinoma (ACC) is an aggressive disease with poor prognosis, and the current therapeutic options, such as mitotane or platinum‐based chemotherapy regimens, often offer limited efficacy. Here, we present the first report, to the author's knowledge, of metastatic ACC with positive octreoscan scintigraphy that was successfully treated with octreotide long‐acting release (LAR). A patient with metastatic ACC who showed poor tolerance to mitotane received octreotide LAR because of positive octreoscan scintigraphy. She obtained major partial response to the somatostatin analog. Interestingly, the expression of somatostatin receptor 2 from the previous local recurrence lesion was negative. The next‐generation sequencing‐based circulating tumor DNA analysis in the patient was performed and failed to identify any alterations. These findings suggest that octreotide LAR may be a good option for the treatment of metastatic ACC in selected patients.

A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience

“…She obtained a major partial response to the somatostatin analog. However, the expression of SSTR2 from the previous local recurrence lesion was negative [ 22 ]. Mariniello et al demonstrated the overexpression of SSTR1 and SSTR2 in 13/13 samples of patients with ACC and reported that pasireotide had an anti-secretory but the not anti-proliferative effect on the H295R cell line [ 18 ].…”