Metastatic Adenocarcinoma of the Cervix: A Case Report

Adenocarcinoma metastatic to the uterine cervix: A case series

“…Finally, we excluded any references that were not available in complete text form or lacked the data we required for this analysis (Table 2). For the purposes of our review, we included 13/16 (81.2%) publications associated with gastric cancer, 14–28 30/45 (66.6%) with breast cancer, 14,18,21,29–55 9/13 (69.2%) with ovarian cancer, 15,18,21,29,56–60 and 10/13 reports (76.9%) related to colorectal cancer 15,18,19,21,61–66 . The total number of patients covered in these reports was 45 for gastric cancer, 36 for breast cancer, 36 for ovarian cancer and 19 for colorectal cancer.…”

Metastatic Carcinoma of the Uterine Cervix from Rectal Carcinoma: A Case Report and Review of the Literature

“…The rarity of uterine cervical metastatic adenocarcinomas has been attributed to: 1) the high fibrous tissue content of the cervix providing an unfavorable medium for metastatic growth; 2) the small size and relatively limited blood flow of the cervix as a target organ; 3) the fact that the lymphatic vessels of the pelvis all drain away from the cervix; 4) the failure to exclude possible primary sites in cases diagnosed as adenocarcinoma of the cervix; and 5) the failure to screen the cervix routinely during follow-up in women with adenocarcinomas of extragenital sites [14]. Failure to examine the cervix during autopsy may also result in an underestimation of the incidence of metastatic adenocarcinoma of the cervix [5] [6] [13] [14] [16].…”

“…Intestinal and mucinous differentiation can be detected histologically in some cases. Immunohistochemical staining is often positive for cytokeratin 20 and negative for cytokeratin 7 [16]. However, histologic findings alone are not always adequate for establishing the site of the primary lesion.…”