Metastatic adenocarcinoma of prostate in a 28-year-old male: The outcome is poor in young patients?

Abstract

Prostate cancer is common in older patients. Rarity in younger population limits the study of natural history and prognosis in this population. Most of the published data has reported poor outcome in younger patients with metastatic prostate cancer. Here, we report a case of prostate cancer in 28-year-old male who presented with bone metastasis. After bilateral inguinal orchidectomy, he was started on anti-androgen therapy and received palliative radiotherapy for bone metastasis. There was only a slight decrease in prostate-specific antigen (PSA) level and pelvic disease post treatment. Subsequently, he was started on opioid analgesics (by World Health Organization, WHO, step ladder) in view of persistent pain. The index case is being presented for its rarity and probable poor outcome in young patients and to stress on the fact that the possibility of primary prostatic adenocarcinoma should be investigated in a male presenting with bone metastasis irrespective of the age.

Câncer de próstata avançado em homem de 37 anos: Uma entidade rara

“…No entanto, ensaios clínicos indicam que tratamento cirúrgico ou radioterapia parece serem preferíveis à vigilância ativa, mesmo em casos classificados como de baixo risco. 6,10,11 A introdução de rastreio do CaP por meio do PSA e toque retal, sem que haja qualquer critério na seleção dos indivíduos, tem sido motivo de controvérsia. É ponto comum, porém, que o screening em grupos de alto risco tem grande impacto, mudando o panorama da doença e adiantando a idade de detecção.…”

Spectrum of urological emergencies and surgical interventions in a single tertiary health center

“…Prostate cancer is rare in younger patients. It has been observed from the available published data that undifferentiated or poorly differentiated adenocarcinoma is the commonest histology in the younger age group and majority present with metastatic disease at outset [ 25 ].…”