Metastatic acinic cell carcinoma in a neurofibroma mistaken for carcinosarcoma

Cohn, Martin A.; Elliott, Danielle D.; El‐Naggar, Adel K.

doi:10.1002/hed.20133

Cited by 10 publications

(6 citation statements)

References 15 publications

(19 reference statements)

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“…Fried in 1930 presented a case of bronchogenic carcinoma metastasizing into a meningioma [7]. Since then, various tumour-to-tumour metastasis case reports and series have been reported in the literature [8][9][10][11][12]. Based on the literature review, the most frequent metastatic donor is lung carcinoma, while renal cell carcinoma and meningioma are the most frequent malignant and benign recipients, respectively [5].…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Co-existence of lung carcinoma metastasis and enchondroma in the femur of a patient with Ollier disease

et al. 2020

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Tumour-to-tumour metastasis is very unusual and has been defined as a tumour metastasis into another histologically different tumour. It is extremely rare in bone. We report a case of lung squamous cell carcinoma metastasized to an enchondroma in the femur of a patient with Ollier disease. A 60-year-old female had a history of a poorly differentiated squamous cell carcinoma of the lung. She underwent a video-assisted thoracoscopic lobectomy, and a follow-up MRI scan showed three lesions in the left distal femur and proximal tibia, which were initially interpreted as metastasis on radiology. Resection of the left proximal tibial lesion was performed, and the pathological findings were consistent with enchondroma with no evidence of metastasis. Subsequent curettage of lesions in the distal left femur revealed metastatic poorly differentiated carcinoma with foci of hyaline cartilage, which was most consistent with metastatic carcinoma in a pre-existing enchondroma. The MRI films were re-reviewed. Characteristic MRI features of enchondroma were found in the lesion in the left proximal tibia and one of the lesions in the left distal femur, while the features of the other lesion in the left distal femur included cortical destruction and extensive oedema in surrounding soft tissue, which were consistent with a malignant tumour. In addition, the enchondroma in the lateral condyle showed blurring and irregular inner margin and adjacent bone oedema, which likely represents a co-existing metastatic tumour and enchondroma. The difference in lineage was confirmed by immunohistochemistry. The final diagnosis was metastatic poorly differentiated carcinoma of the lung into a co-existent enchondroma. The diagnosis can be challenging and could be easily overlooked both radiologically and histologically. Thorough clinical and radiological information is critical for the diagnosis, and despite a very unusual event, awareness of the tumour-to-tumour metastasis phenomenon can avoid an inaccurate diagnosis by the pathologist, therefore preventing inappropriate clinical intervention.

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Section: Discussion and Literature Reviewmentioning

confidence: 99%

Co-existence of lung carcinoma metastasis and enchondroma in the femur of a patient with Ollier disease

et al. 2020

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“…None of their cases showed recurrence or metastasis involving the skin, but isolated case reports of concurrent cutaneous involvement has been reported 4,5 . Cohn, Elliott and El‐Naggar report a case of acinic cell carcinoma, approximately 2 years after initial diagnosis, metastatic to the bone, lung and skin limited to the scalp 6 7 …”

Section: Discussionmentioning

confidence: 99%

Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentation

Varsegi¹,

Ravis

Hattab³

et al. 2008

J Cutan Pathol

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Acinic cell carcinoma is a rare, low-grade malignant salivary gland neoplasm. Approximately, 20% of patients experience local recurrence and 10% distant metastasis, often many years after initial presentation. We present a case of widespread cutaneous metastasis from acinic cell carcinoma arising in a 59-year-old woman with a history of acinic cell carcinoma of the parotid gland 20 years prior to her cutaneous disease. To our knowledge, is the first report of widespread cutaneous metastasis from acinic cell carcinoma.

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“…According to a PubMed and Ovid database search, only 42 cases of cutaneous metastases from parotid neoplasms have been reported since 1956 (search date January 1, 1956, to July 31, 2020). 9–48 We describe 2 cases of parotid malignancies with cutaneous metastasis and a literature review of cutaneous metastasis from parotid tumors.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

Puerto

Jaque

González-Bombardiere³

et al. 2021

The American Journal of Dermatopathology

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Cutaneous metastases from parotid tumors are uncommon and imply a poor prognosis. In this article, we report 2 new cutaneous metastasis cases from 2 different parotid malignancies and 42 additional cases from a literature review. Clinical manifestations, localization, and outcomes of skin metastasis from parotid tumors are described. Although infrequent, parotid neoplasms may develop skin metastasis many years after the initial diagnosis, mostly in the head and neck region. Therefore, long-term follow-up and periodic skin examination of these patients is mandatory. Dermatologists and surgeons must have a high index of suspicion when evaluating any skin lesion arising on these patients because cutaneous metastasis from parotid neoplasms generally implies a poor prognosis.

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Metastatic acinic cell carcinoma in a neurofibroma mistaken for carcinosarcoma

Abstract: To our knowledge, this is the first reported case of acinic cell carcinoma metastatic to a neurofibroma, an important entity in the differential diagnosis of biphasic tumors of the head and neck.

Cited by 10 publications

References 15 publications

Co-existence of lung carcinoma metastasis and enchondroma in the femur of a patient with Ollier disease

Co-existence of lung carcinoma metastasis and enchondroma in the femur of a patient with Ollier disease

Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentation

Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

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