Metastasizing Mixed Tumor of Salivary Glands

Wenig, Bruce M.; Hitchcock, Charles L.; Ellis, Gary L.; Gnepp, Douglas R.

doi:10.1097/00000478-199209000-00003

Cited by 132 publications

(22 citation statements)

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“…[1][2][3][4] One of the most important features of metastasizing mixed tumour is the association with recurrence; metastatic spread of the tumour is usually preceded by recurrent mixed tumour. [1][2][3][4][5][6][7] • Case report of a pleomorphic adenoma of the parotid, presenting with metastatic disease in the lung • The patient had had preauricular masses excised 17 and 23 years previously, pathology unknown • Previous cases have been reported; this case confirms the potential malignant nature of a disease generally considered to have a benign course…”

Section: Discussionmentioning

confidence: 71%

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Metastasizing mixed tumour of the parotid gland presenting as multiple lung metastases

et al. 2004

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Metastasis is a feature of malignant neoplasms. Although rare, metastasizing pathologically benign mixed tumour has been reported. This report describes a 33-year-old woman with multiple lung metastases from mixed tumour. A small preauricular mass had been removed 23 years earlier. Six years later, the patient had the same symptom; the recurrent mass was resected. She was not aware of the exact pathological diagnosis of the previous tumours. One of the most common features of metastasizing mixed tumour is recurrence at the primary site. Inadequate resection of the primary tumour is often associated with metastasis. Thus, it is important for the head and neck surgeon to be aware of the concept of pathologically benign metastasizing mixed tumour and the importance of adequate surgical procedure.

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Section: Discussionmentioning

confidence: 71%

“…recurrence; metastatic spread of the tumour is usually preceded by recurrent mixed tumour. [1][2][3][4][5][6][7] • Case report of a pleomorphic adenoma of the parotid, presenting with metastatic disease in the…”

Section: Discussionmentioning

confidence: 99%

Metastasizing mixed tumour of the parotid gland presenting as multiple lung metastases

et al. 2004

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“…Haematogenous metastasis is more prevalent than metastasis to regional lymph nodes [14] . However, a lymphatic metastatic route has also been reported [15] . Here, the presence of deposits in the liver and thyroid as well as the lack of lymphatic involvement suggests a haematogenous route of spread.…”

Section: Discussionmentioning

confidence: 99%

“…The development of metastases within the first 10 years of diagnosis or at multiple sites are independent predictors of worse survival [15] . Long-term follow-up is therefore necessary after treatment of a metastatic lesion considering the demonstrated delay in presentation of subsequent pathology [5] .…”

Section: Discussionmentioning

confidence: 99%

A unique case of benign pleomorphic adenoma metastasizing to the thyroid gland and liver

Moonim

Wiles

Nasir

et al. 2015

CRCP

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AbstractsA recurrent benign metastasizing pleomorphic salivary adenoma (PSA) is extremely rare occurring in less than 1% of patients. There are approximately 50 cases that have been reported in the literature but none with metastases to the thyroid gland. We report a case of a 68-year-old lady who was initially investigated for a space-occupying lesion in the liver but was found to have metastases in the thyroid and liver as well as recurrence of the parotid primary. The clinical findings, management, and a review of the current literature are reported. Metastases from PSAs are extraordinary. We describe the first reported metastasis from the parotid to the thyroid gland. In this case, we report an excellent outcome post-operatively and argue for the benefit of long-term follow-up.

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“…First, as already mentioned, CXPA is a rare entity, and literature on the subject is sparse, so physicians may not have the information necessary to accurately diagnose the condition. Second, some PAs are histologically malignant but behave in a benign manner [4] , while other PAs are histologically benign but metastasize [5] . Lastly, diagnosis is complicated because the malignant component is often small and overlooked [6,7] .…”

Section: Introductionmentioning

confidence: 99%

The incidence of salivary carcinoma ex pleomorphic adenoma: A SEER database review and review of the literature

Rebhun

Wein

2015

JST

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Our review included 988 cases of carcinoma ex pleomorphic adenoma (CXPA) in the Surveillance, Epidemiology, and End Results database from 1973-2011 and includes the parotid, submandibular gland, sublingual gland, oral cavity and pharynx. The most common location for CXPA was the parotid gland with a decrease in the reported overall incidence rate noted since 1973. A racial predilection was noted (Black greater than White) and a higher incidence was noted in males. Grade III CXPA had the worst 5-and 10-year disease specific survival. The overall average incidence rate of CXPA for 1973-2011 was 0.68 persons per million. The overall 5-and 10-year survival for CXPA was 63.2% and 44.6%, respectively.

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Metastasizing Mixed Tumor of Salivary Glands

Cited by 132 publications

References 0 publications

Metastasizing mixed tumour of the parotid gland presenting as multiple lung metastases

Metastasizing mixed tumour of the parotid gland presenting as multiple lung metastases

A unique case of benign pleomorphic adenoma metastasizing to the thyroid gland and liver

The incidence of salivary carcinoma ex pleomorphic adenoma: A SEER database review and review of the literature

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