Metastasizing meningioma

Shuangshoti, Samruay; Hongsaprabhas, Chaturaporn; Netsky, Martin G.

doi:10.1002/1097-0142(197010)26:4<832::aid-cncr2820260416>3.0.co;2-s

Cited by 81 publications

(29 citation statements)

References 22 publications

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“…A few cases showing extracranial metastasis were reported to have received repeated craniotomy (Rubinstein, 1972;Karasick and Mullan, 1974;Shuangshoti, Hongsaprabhas and Netsky, 1970). Our observations on the metastasis of human meningioma in nude mice undergoing surgery seem in accordance with these findings.…”

supporting

confidence: 88%

“…Histologically, malignant behaviour of meningioma is usually difficult to predict, although the angioblastic type or tumours with papillary structure are reported to be more likely to metastasize (Shuangshoti et al, 1970;Rubinstein, 1972). It is interesting that the histological type in this case was fibroblastic meningioma with abundant collagen fibres and little atypism or mitosis, in spite of clinical malignancy as shown by gross invasion of the brain, venous sinuses, bone and muscle.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Xenotransplantation of a human meningioma and its lung metastasis in nude mice

Ueyama¹,

Morita²,

Ochiai³

et al. 1978

Br J Cancer

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supporting

confidence: 88%

mentioning

confidence: 99%

Xenotransplantation of a human meningioma and its lung metastasis in nude mice

Ueyama¹,

Morita²,

Ochiai³

et al. 1978

Br J Cancer

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“…1,3,4,[6][7][8][9][11][12][13][14]16,19) The risk of CSF dissemination of this tumor is not clear. Twelve of these 18 patients had undergone two or more surgical procedures.…”

Section: Discussionmentioning

confidence: 99%

Malignant Intracranial Meningioma With Spinal Metastasis -Case Report-

Kuroda

Kashimura

Ogasawara

et al. 2009

Neurol. Med. Chir.(Tokyo)

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A 48-year-old woman presented with a left cerebellopontine angle mass. Over a 93-month period, the patient underwent seven surgeries, two radiosurgeries, and one external beam radiotherapy. The tumor was histologically benign at the first operation, but exhibited unusually aggressive behavior after failed radiosurgery and demonstrated clinical characteristics of malignancy such as spinal metastasis. The patient underwent gamma knife radiosurgery (GKR) for recurrence after the first operation, despite the tumor being located in a resectable region. The tumor did not respond. Six months after the sixth surgery, the patient presented with progressive lower extremity paraparesis and sensory disturbance below the T11 dermatome. Magnetic resonance imaging revealed multiple intradural mass lesions located at the T2, T11-T12, and L2 levels. She died 4 months after the diagnosis of spinal metastases. Retrospectively, we speculate that if a tumor is located in a resectable region and Simpson grade I or II tumor resection is possible, direct surgery may be a safer option than GKR.

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“…4 Metastasis from a CNS meningioma is the least likely reason for an extracranial meningioma in the head and neck region. 5 Because there was no continuity with the intracranial region and no primary brain lesion present on CT, the mandibular lesion probably arose from transformed fibroblasts or displaced arachnoid cells. Lang et al 6 proposed a single term "primary extradural meningioma" for these lesions.…”

Section: 2mentioning

confidence: 99%

Meningioma of the Mandible: Imaging with CT

Mussak

Holodny²,

Karimi³

2007

American Journal of Neuroradiology

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SUMMARY:We present the first description of CT of a meningioma of the mandible in the literature. Extracranial meningiomas are exceedingly rare. There have been 3 cases of meningioma of the mandible described in the literature, but none characterized with cross-sectional imaging. We describe the clinical and CT features used to establish the diagnosis as well as how to differentiate this lesion from other pathology of the mandible. Only 3 cases of a meningioma of the mandible have been described in the literature.1,2 The mandibular meningiomas are classified as primary extracranial meningiomas. Extracranial meningiomas are usually an extension of an intracranial tumor but can arise independently, such as meningioma of the mandible. The independent formation of these tumors is believed to involve meningocytes along the sheaths of cranial nerves as they exit the skull foramina, fibroblastic mesenchymal cell transformation, or displaced arachnoid cap cells. Metastasis from a central nervous system (CNS) meningioma can naturally give rise to an "ectopic" meningioma as well. Extracranial meningiomas are exceptionally rare. To our knowledge, we report the first CT findings of a mandibular meningioma. Case ReportA 62-year-old man presented with fullness on the left mid-body of the mandible. The patient's history dated to 2 years earlier when he sought consultation from his dentist. A swelling was noted on his left lower gum with mild pain, which was clinically thought to represent an abscess. Plain films revealed a large well-delineated radiolucent lesion involving the mandibular body. He was treated with 4 different antibiotic regimens during the following year with no regression of the mass. The patient denied any bleeding from the oral cavity or any problems with speech or mastication. At that point, his primary care physician referred him to an otolaryngologist for further management and work-up of the mass.The work-up included a CT of the mandible without contrast, which showed a well-circumscribed lytic expansile mass involving the mandibular body on the left side, which broke through the cortex at several different sites. The mass measured approximately 7 ϫ 3 cm (anteroposterior ϫ transverse) and spanned from the alveolar ridge to the inferior cortex. Posteriorly, the lesion extended 1 cm from the angle of the mandible and anteriorly 1.8 cm from the mentum (Fig 1). There was no evidence of gross tumor extending into the infratemporal fossa along the course of V3, and the foramen ovale was normal on the CT scan.A fine-needle aspiration of the mass was performed. Cytologic analysis revealed neoplastic spindle cells present with minimal nuclear and cytologic atypia. The sample was reviewed at an intradepartmental pathology conference and was determined to represent an extracranial meningioma. The patient was then recommended for segmental mandibulectomy and mandibular reconstruction with a fibula free flap.Postoperatively, the left submandibular gland and left mandible were submitted to surgical pathology for analy...

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Metastasizing meningioma

Cited by 81 publications

References 22 publications

Xenotransplantation of a human meningioma and its lung metastasis in nude mice

Xenotransplantation of a human meningioma and its lung metastasis in nude mice

Malignant Intracranial Meningioma With Spinal Metastasis -Case Report-

Meningioma of the Mandible: Imaging with CT

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