Metastasizing Malignant Granular Cell Tumor (Abrikossoff Tumor) of the Anterior Abdominal Wall, with Prolonged Survival

Alnashwan, Yara A.; Ali, Khaled; Amr, Samir S.

doi:10.1155/2019/9576487

Cited by 12 publications

(28 citation statements)

References 46 publications

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“…Due to the small number of cases, there are not many reports on the survival of malignant GCM. However, it is generally believed that it is closely related to the tumor's size, local invasion, and distant metastasis [24,38]. It took less than a year from discovery to death in our case.…”

Section: Discussionmentioning

confidence: 59%

Bladder Malignant Granular Cell Tumor With EP300 Gene Mutation: A Case Report and Literature Review

Huang

Zhu

Ren

et al. 2021

Preprint

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Background Malignant granular cell tumor (GCT) is extremely rare. Malignant GCT with EP300 gene mutation in the bladder has not been reported in the literature.Case presentation We report a special case of 45 years old female with malignant GCT of the bladder. Physical examination found a pelvic mass in the patient. Magnetic resonance imaging showed a huge mass between the posterior wall of the bladder, the cervix, and the anterior wall of the vagina. Pathological examination showed that the mass was 11×11×4.5cm in size, involved in the bladder's posterior wall. Under the microscope, the tumor cells were arranged in the shape of a nest or cord to infiltrate the bladder's wall. The tumor cells were pleomorphic, red-stained granular within the cytoplasm, with increased nuclear/cytoplasmic ratio, vacuolar nuclei, and obvious nucleoli. The tumor cells were showed obvious nuclear atypia, and the mitosis was more than 5/50HPF. Coagulative necrosis was widely showed within the tumor. Immunohistochemistry(IHC) showed that S-100, NSE, CD68, CR, α-AT, and TFE-3 were strongly positive, and the Ki-67 proliferation index was around 15%. The next-generation high throughput sequencing indicated that EP300 gene was missense mutated (c.457A>G) with 33% mutation abundance, and genes of DPYD(c.1627A>G),ERCC1( c.354T>C),NQO1(c.559C>T),TPMT(c.719A>G) and XRCC1(c.1196A>G) were polymorphic mutated. The patient died after three months of the second surgical treatment. Conclusions We report for the first time a primary bladder malignant GCM accompanied by mutations in special driving genes such as EP300. We also conducted a comprehensive literature review and an in-depth discussion.

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Section: Discussionmentioning

confidence: 59%

Bladder Malignant Granular Cell Tumor With EP300 Gene Mutation: A Case Report and Literature Review

Huang

Zhu

Ren

et al. 2021

Preprint

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“…MGCT is an exceedingly rare and aggressive tumour, representing less than 1 -2% of all GCT and 0.2% of all soft tissue sarcomas [6]. The commonest sites involved are extremities and trunk.…”

Section: Discussionmentioning

confidence: 99%

“…In 1998, Fanburg Smith et al established the criteria for diagnosing benign, atypical, and malignant granular cell tumours based on histological features as highlighted in the introduction above. However, presence of metastases is the only definite criteria for malignancy for GCT [1,5,6].…”

Section: Discussionmentioning

confidence: 99%

“…Local recurrence and metastasis are significantly high in MGCT, with a 32 % of recurrence rate and metastases in 50 %. The most common metastatic sites are regional lymph nodes, lungs and bones [5,6]. It has been established that older age group, larger tumour size, local recurrence, metastasis, mitotic index of >10%, and p53 immunoreactivity are all adverse prognostic factors [6].…”

Section: Introductionmentioning

confidence: 99%

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Malignant Granular Cell Tumour of the Thigh with Lung Metastases in a Young Woman; A Rare Presentation

Hiroshini¹,

Vithanage²

2019

J Diagnostic Path

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Granular Cell Tumour (GCT) is an uncommon soft tissue neoplasm. Majority of GCT are benign involving the soft tissue of the head and neck region. However, few show malignant behaviour with local recurrence and distant metastases often involving the lower extremities. Here we report a rare case of malignant granular cell tumour in a 33year-old woman involving the left thigh with regional lymph node and multiple lung metastases.

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“…They commonly affect premenopausal women. 2 They can occur in any part of the body like head, neck, chest wall, dermis, oral mucosa including tongue, breast and gastrointestinal tracts. 3,4 Granular cell tumors of the breast account for 5-15% of all GCTs and approximately 1 in 1000 cases of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Granular Cell Tumor of Breast: Rare Tumor Masquerading as Malignancy

Hirachan

Singh

Jha

et al. 2020

Journal of Institute of Medicine

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Granular cell tumor (GCT) is a rare soft tissue tumor that arises from the Schwann cells of peripheral nerves. It was first postulated by Abrikossoff in 1926 as Myoblastoma. About 5-15% of these tumors occur in the breast and less than 1% has the potential to be malignant. Here we present a case of 41 years old premenopausal woman with Benign GCT of the right breast, having clinically malignant features. The clinical and radiological features of GCT are similar to malignant lump. However, histology showing presence of sheets of polygonal cells with abundant granular eosinophilic cytoplasm with round nuclei and granules with Periodic acid–Schiff (PAS) positive, diastase resistant and S-100 antigen positive are confirmatory. Treatment of Granular cell tumor is wide local excision. There is apparently no role of chemotherapy and radiotherapy. The presence of GCT in the breast is quite rare and clinically as well as radiologically it may mimic malignancy, however with histopathology and appropriate immunohistochemistry, proper diagnosis can be made.

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Metastasizing Malignant Granular Cell Tumor (Abrikossoff Tumor) of the Anterior Abdominal Wall, with Prolonged Survival

Cited by 12 publications

References 46 publications

Bladder Malignant Granular Cell Tumor With EP300 Gene Mutation: A Case Report and Literature Review

Bladder Malignant Granular Cell Tumor With EP300 Gene Mutation: A Case Report and Literature Review

Malignant Granular Cell Tumour of the Thigh with Lung Metastases in a Young Woman; A Rare Presentation

Granular Cell Tumor of Breast: Rare Tumor Masquerading as Malignancy

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