Metastasizing Atypical Fibroxanthoma (Cutaneous Malignant Histiocytoma)

Sentinel Lymph Node Biopsy for High-Risk Nonmelanoma Skin Cancers

“…AFX is another cutaneous malignancy for which the SLNB has been suggested because of possible metastasis to regional lymph nodes 21 . Our patient with AFX had satellite recurrences and a tumor histology showing numerous mitotic figures.…”

Atypical Fibroxanthoma: A Review of the Literature

“…There have been 25 reports of metastatic AFX in the literature, 11,107–110 although there may be more before 1961 published under a different name 11 . Cooper and colleagues 11 reported five cases of metastatic AFX with metastasis to regional lymph nodes, the liver, the lungs, and cutaneous or subcutaneous metastatic disease. Other reports show metastasis to similar areas, including the peritoneum 108–114 .…”

Pathology Quiz Case 3: Diagnosis

“…It usually presents as a solitary nonpigmented nodule on sun-exposed skin. 4 Although AFX is typically solitary, there have been 3 reports of multifocal AFX in the literature. 1,2 It is a rapidly growing tumor and measures between 1.5 and 2 cm in mean diameter on presentation.…”

“…The local recurrence rate after treatment has been reported to be 0% to 7% with Mohs surgery 3,7 and up to 12% with wide local excision. 2,4,7,10 There have been at least 21 reported cases of metastases in the literature, including extension of disease to regional lymph nodes, skin, liver, and lungs. 2,4,7,10 There have been at least 21 reported cases of metastases in the literature, including extension of disease to regional lymph nodes, skin, liver, and lungs.…”

“…9,10 Postoperative radiation therapy has been administered to patients with positive margins, incomplete resections, or recurrence. 4 However, there is controversy as to whether these cases might reflect a misdiagnosis, as MFH is more noted for its metastatic potential. 4 However, there is controversy as to whether these cases might reflect a misdiagnosis, as MFH is more noted for its metastatic potential.…”