Metastasizing atrial myxoma

Seo, In Sook; Warner, Thomas F.; Colyer, Robert A.; Winkler, Ralph F.

doi:10.1097/00000478-198008000-00008

Cited by 38 publications

(13 citation statements)

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“…In our study left atrial tumors presented with arterial hypertension, syncope, and cardiac insufficiency and these findings were similar to the reported clinical picture for left cardiac myxomas [1,15,16,33]. On the basis of our findings it could be suggested that right-sided myxomas tend to be mainly sessile, they frequently are surfaces for thrombosis and become sites of amorphous calcifications.…”

Section: Discussionsupporting

confidence: 90%

“…Thus, they are relatively rare neoplasms, but they are still the most common benign neoplasms of the human heart [1,4,5]. As myxoma is the most common primary cardiac tumor and fibroelastoma is the second one, the operated cardiac mass turned out to be a non-neoplastic thrombus in up to 15.5% in a study of Strucker et al [6].…”

Section: Introductionmentioning

confidence: 99%

“…syncope [14]. Furthermore, the coronary arteries may be affected by tumor-derived, myxomatous emboli that rarely cause acute myocardial infarction or evident tumor displacement [15]. Typically, well-formed, pedunculated tumors are detected easily in the left atrium, with a possibility of protrusion into the ventricular chamber [16].…”

Section: Introductionmentioning

confidence: 99%

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Ancient cardiac myxomas – another point of view in the light of tetraspanins

Lewitowicz

Bernaczyk²,

Horecka-Lewitowicz³

et al. 2016

pjp

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Ancient cardiac myxomas – another point of view in the light of tetraspanins

Lewitowicz

Bernaczyk²,

Horecka-Lewitowicz³

et al. 2016

pjp

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“…Atrial myxomas are usually considered benign, but recurrences and dis tant métastasés have both been documented, suggesting that a myxoma may be malignant [6,7], A potential for malignancy in atrial myxo ma is evidenced by sarcomatous changes such as large and irregular nuclei, prominent mi toses, and hypercellularity [8]. Our patient…”

Section: Discussionmentioning

confidence: 82%

“…Two note worthy publications [8,9] reported a detailed pathological study, including electron micros copy, of a metastatic myxoma and showed that the histological picture was benign. These findings suggest that a nonmalignant myxoma is in fact capable of metastatic spread.…”

mentioning

confidence: 99%

Cardiac Myxoma Metastasized to the Brain: Potential Role of Endogenous lnterleukin-6

Wada

Kanda²,

Hayashi³

et al. 1993

Cardiology

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Metastasis of a cardiac myxoma to the brain is extremely rare. We present the case of a 70-year-old man who had an atrial myxoma and two metastatic myxomas in the brain. The intra-cranial lesions were in fact diagnosed before the cardiac myxoma, since the patient developed hemiparesis before his cardiac symptoms occurred. Computerized tomography of the brain showed two high-density lesions, the larger of which was removed surgically. Follow-up computerized tomography revealed a progressive enlargement of the second lesion which was then resected. Histopathological examination showed all lesions to the benign myxomas. Interestingly, high concentrations of interleukin-6 were present in the patient’s serum and cardiac myxoma. Interleukin-6 may possibly potentiate metastasis of cardiac myxoma.

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Glandular cardiac myxomas histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation

Goldman

Frydman

Harpaz

et al. 1987

Cancer

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Histologic, histochemical, immunocytochemical, and ultrastructural features of two cardiac myxomas containing glandular elements are reported. Glandular elements in both cases stained positively with both mucicarmine and periodic acid-!khiff reagent with diastase pretreatment (DPAS). Immunoperoxidase studies demonstrated positivity of the glandular cells for carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), and keratin. Factor VIII-related antigen (FVIIIAg) was identified only in cells lining vascular spaces. Electron microscopic study of one tumor demonstrated well-formed glands having basement membranes, junctional complexes, and apical secretory granules. These findings indicate the capacity for true epithelial differentiation of cardiac myxomas and have implications both as regards the histologic diagnosis of these tumors and their histogenesis. Cancer 59:1767-1775, 1987. ARDIAC MYXOMA is the most common primary tu-C mor of the heart,',* and is considered by most authors to be a mesenchymal neoplasm and not merely the result of a thrombotic proce~s.',~-~ One characteristic of myxomas which has been cited as evidence for their neo-plastic nature is the occasional presence of histologically distinct gland-like elements within tumors which are otherwise grossly and microscopically typical of m y ~ o m a. ~ Although previous studies of cardiac myxomas have described the light m i c r o s ~ o p i c ~ ~ ~ and ultra~tructural~ features of such glandular elements, studies of the immu-nohistochemical characteristics of these structures have been limited to the demonstration of positivity for Factor VIII-related antigen (FVIIIAg), a finding which has been interpreted as supporting an endothelial origin for these turn or^.^ Although other ultra~tructural~~~ and immuno-histochemical' studies of cardiac myxomas have demonstrated tumors comprising a heterogeneous population of cells with features of endothelium, smooth muscle cells,

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Metastasizing atrial myxoma

Cited by 38 publications

References 0 publications

Ancient cardiac myxomas – another point of view in the light of tetraspanins

Ancient cardiac myxomas – another point of view in the light of tetraspanins

Cardiac Myxoma Metastasized to the Brain: Potential Role of Endogenous lnterleukin-6

Glandular cardiac myxomas histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation

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