Metastasizing Ameloblastoma: A 10 Year Clinicopathological Review with an Insight Into Pathogenesis

Pandiar, Deepak; Kamboj, Mala; Narwal, Anjali; Shameena, PM; Devi, Anju

doi:10.1007/s12105-020-01258-5

Cited by 13 publications

(5 citation statements)

References 45 publications

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“…The mean age of occurrence of metastasizing ameloblastoma is 43±16 years, with a slight male predilection. The mandibular cases showed more metastasis than the maxillary cases, and lungs, followed by lymph nodes, are the most commonly affected secondary sites [27].…”

Section: Clinical Presentationmentioning

confidence: 95%

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Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Ghai¹

2022

Cureus

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Ameloblastoma is one of the most common benign odontogenic tumors of the jaw that constitutes about 10% of all tumors that arise in the mandible and maxilla. It is a slow-growing but locally invasive tumor that presents with painless swelling of the mandible or maxilla. The World Health Organization (WHO) classification of 2017 describes ameloblastomas of the following four types: ameloblastoma; unicystic ameloblastoma; extraosseous/peripheral ameloblastoma; and metastasizing ameloblastoma. The diagnosis of ameloblastoma requires computerized tomography (CT) imaging as well as a biopsy. A biopsy is helpful in differentiating ameloblastoma from ossifying fibroma, osteomyelitis, giant cell tumor, cystic fibrous dysplasia, myeloma, and sarcoma. The best treatment of ameloblastoma is aggressive en bloc resection with simultaneous reconstruction. The high recurrence rate and large tissue defects have been long-standing issues in the treatment of ameloblastoma. Recent molecular developments strongly suggest the possibility of targeted therapy with better outcomes in ameloblastomas. We present a detailed updated narrative review of our current understanding and management of this enigmatic tumor.

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Section: Clinical Presentationmentioning

confidence: 95%

“…Follicular ameloblastoma was most frequently encountered at the secondary site followed by the plexiform type. Lungs were the most commonly affected secondary sites [27].…”

Section: Histopathological Findingsmentioning

confidence: 99%

Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Ghai¹

2022

Cureus

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“…According to the World Health Organization in 2017, ameloblastomas are classified into (1) conventional ameloblastoma (previously known as “solid/multicystic ameloblastoma”) which includes patterns: follicular, plexiform, acanthomatous, acanthomatous histopathologic variants, granular cell, basal cell, and desmoplastic; (2) unicystic ameloblastoma with luminal, intraluminal, and mural variants; (3) extraosseous/peripheral ameloblastoma; and (4) malignant or metastatic ameloblastoma. Histologically, it is characterized by tumor nests that resemble the epithelial component of the enamel organ, columnar to cuboidal cells with hyperchromatic nuclei arranged in a palisading pattern with reverse polarity, and the central core is reminiscent of stellate reticulum [ 1 , 4 , 24 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis

et al. 2022

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Ameloblastoma is a rare benign epithelial odontogenic neoplasm, but with great clinical implications, as despite its benignity and slow growth, most cases are locally aggressive with a significant recurrence rate. Histological, cellular, or molecular analyses of its pathogenesis have confirmed the complexity of this neoplasm. We present the case of a 20-year-old patient with a suggestive clinical and radiographic diagnosis of ameloblastoma. An incisional biopsy was obtained confirming the diagnosis of conventional ameloblastoma. Left hemimandibulectomy and plate reconstruction were performed. Histopathological analysis of the surgical specimen confirmed the conventional ameloblastoma with a plexiform pattern and significant areas of cystic degeneration and amyloid-like-like deposits. Additionally, a microarray was carried out with bioinformatic analysis for the enrichment, protein interaction, and determination of eight hub genes (CRP, BCHE, APP, AKT1, AGT, ACTC1, ADAM10, and APOA2) related to their pathogenesis.

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“…9 The average age at which this occurred in METAM was 42.71 years, with a slight predilection for men. 5 Ameloblastoma tends to be more prevalent in developing nations, such as India, where cancer strikes at a younger age. This disparity in ameloblastoma demographic distribution may be connected to an accelerated aging process caused by poor nutrition and limited access to healthcare services.…”

Section: Epidemiologymentioning

confidence: 99%

Ameloblastoma

Haryono,

Purnomo,

Philo

2023

Int Surg J

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Ameloblastoma is a noncancerous tumor that originates from epithelial tissue in the oral cavity. It is regarded as one of the most aggressive odontogenic tumors (OT) in several nations throughout the world. If left untreated, they can grow to be quite big, causing facial disfigurement and functional issues. The treatment of ameloblastoma depends on the size, location, and histological subtype of the tumor. Surgical resection is the mainstay of treatment, and various techniques have been developed to minimize morbidity and recurrence.

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Metastasizing Ameloblastoma: A 10 Year Clinicopathological Review with an Insight Into Pathogenesis

Cited by 13 publications

References 45 publications

Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis

Ameloblastoma

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