Metastasising gliomas in young subjects

Eade, O E; Urich, H.

doi:10.1002/path.1711030407

Cited by 79 publications

(32 citation statements)

References 15 publications

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“…In the similar cases reported in the literature, the interval between the onset of spinal cord symptoms and the onset of intracranial symptoms varied from 1 week to 1 year. 6,18,[21][22][23] MRI is the diagnostic procedure of choice for spinal tumours. 24 In the presented case, MRI was able to accurately define the tumour extending from T 9 to T 11 .…”

Section: Case Reportmentioning

confidence: 99%

Spinal glioblastoma with brain relapse in a child: clinical considerations

2005

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Case report: Spinal cord glioblastoma in children has only rarely been reported. It most frequently involves the thoracic region with a predilection for the second and third decades of life. This report describes one case of thoracic glioblastoma multiforme in a 6-year-old child and reviews other cases reported in the literature. Results: Laminectomy and excision of the tumour were performed. Postoperative radiotherapy and chemotherapy were given, but 4 months later the patient presented with a brain relapse of the tumour. At 9 months after diagnosis the patient died from cerebral tumour regrowth. Conclusions: Full neuraxis MRI is always recommended in order to detect possible metastases. The prognosis after multimodality therapy (surgery, radiotherapy, chemotherapy) remains poor. From the literature, only four cases of paediatric patients with long-term survival have been reported.

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Section: Case Reportmentioning

confidence: 99%

Spinal glioblastoma with brain relapse in a child: clinical considerations

2005

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“…Extracranial metastasis of anaplastic cerebral gliomas is rare, while spreading of some of these tumours through the cerebrospinal pathways is not infrequent (@ Eade andUrich 1971, Rubinstein 1972). Acceptable cases of metastasizing gliomas have to meet the criteria outlined by Weiss (1955).…”

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confidence: 98%

Extracranial metastases of anaplastic cerebral gliomas

et al. 1976

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Seven cases are reported of anaplastic cerebral gliomas with metastases outside the neuraxis, seen among about 1500 gliomas. There were two children with anaplastic ependymomas, one adult with oligodendroglioma, and four young to middle-aged adults with astrocytomas grade III and IV. All patients had one or more craniotomies, and four had radiotherapy prior to the appearance of distant tumour deposits. The survival times ranged from 7 to 31 months in cases with gliomas grade II, and from 8 to 18 months with high grade astrocytomas. All seven tumours showed invasion of the meninges, ventricular walls, or both, and in four cases they transgressed the dura and surrounding bone or soft tissues. In six autopsy cases there was widespread dissemination of gliomas through the CSF pathways. Distant metastases involved regional or distant lymph nodes in six patients, the lungs in two, and the vertebrae, pleura, liver, or mediastinum in one patient each. The possible pathways for distant spread or intracranial gliomas and the factors which are considered responsible are briefly discussed.

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“…In those cases with bone metastases of any type, lesions could be either osteolytic, [5,7,11,24,32,35] osteoblastic, [9,15,16,25] or mixed [19]. For patients with vertebral metastases, the radiographic findings were either discovered pursuant to patient symptoms or lesions found on bone scans or incidentally.…”

Section: Discussionmentioning

confidence: 96%

Vertebral collapse with quadraparesis due to metastatic gliobla multiforme: case report and review of the literature

et al. 1993

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A case is reported of a patient rendered quadraparetic following collapse of a cervical vertebra due to neoplastic invasion by metastatic glioblastoma multiforme. The case is discussed in light of a review of the world literature regarding the clinical incidence and significance of metastasis of glial tumors. It is recommended that all patients with high grade glial tumors who complain of back pain be evaluated with plain radiographs and MRI of the spine or 99Tc bone scan. The management of pathologic spine fractures from metastatic glial tumors with accompanying spinal instability or spinal cord compression due to intracanalicular bone should aim for immediate surgical decompression and stabilization followed by involved field irradiation.

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Metastasising gliomas in young subjects

Cited by 79 publications

References 15 publications

Spinal glioblastoma with brain relapse in a child: clinical considerations

Spinal glioblastoma with brain relapse in a child: clinical considerations

Extracranial metastases of anaplastic cerebral gliomas

Vertebral collapse with quadraparesis due to metastatic gliobla multiforme: case report and review of the literature

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