Metastasis to the Thyroid Gland

Hegerova, Livia; Griebeler, Marcio L.; Reynolds, Jordan; Henry, Michael R.; Gharib, Hossein

doi:10.1097/coc.0b013e31829d1d09

Cited by 136 publications

(71 citation statements)

References 29 publications

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“…The clinical symptoms were not specific. In the majority of cases, the revelation mode is a unifocal lesion of the thyroid, although multifocal or diffuse involvement is also seen [7]. The biological thyroid is usually in favor of euthyroidism and the thyroglobulin is normal.…”

Section: Discussionmentioning

confidence: 99%

“…The proportion of these intrathyroid metastases reaches 24.2% in autopsy series, indicating that such metastatic involvements are much more common than has been clinically appreciated [3]. In these autopsy series, the breast and lung cancers are the predominant etiologies in North America [6] and digestive cancers (esophagus and stomach) in Asia [7]. In these regions, pulmonary origin is, respectively, 13.6 [6] and 25% [7] of the intrathyroid metastases.…”

Section: Introductionmentioning

confidence: 99%

“…In these autopsy series, the breast and lung cancers are the predominant etiologies in North America [6] and digestive cancers (esophagus and stomach) in Asia [7]. In these regions, pulmonary origin is, respectively, 13.6 [6] and 25% [7] of the intrathyroid metastases. Other authors [2] noted that pulmonary origin represented 45.4% of intrathyroid metastases.…”

Section: Introductionmentioning

confidence: 99%

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Lung adenocarcinoma with thyroid metastasis: a case report

Dao

Jabir²,

Taleb³

et al. 2017

BMC Res Notes

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BackgroundThe metastases of a primary lung cancer over the thyroid gland are extremely rare. We report on an unusual presentation of thyroid metastasis of lung cancer in order to improve the management of similar cases.Case presentationThree years ago, a Moroccan male 59-year-old was admitted for dyspnea, dry cough, and chest pain. He had smoked about 30 cigarette packs a year. Clinical examination revealed a right thyroid nodule. Chest and neck computed tomography (CT) scan showed a proximal left tumor in contact with the pulmonary artery and revealed a suspected nodule in the right lobe of the thyroid with homolateral neck node. Transbronchial biopsy was performed and pathological examination revealed adenocarcinoma of the lung and positive for thyroid transcription factor. Other explorations carried out, such as brain CT, bone scan and abdominal ultrasound were normal. After a repeated negative fine needle aspiration biopsy of the suspected nodule of the right lobe of the thyroid, we performed total thyroidectomy with neck dissection. An anatomopathologic exam revealed a tubulopapillary adenocarcinoma poorly differentiated. An Immunohistochemistry showed positive tumor cells with TTF1 and cytokeratin (CK) 7 but negative cells with thyroglobulin and CK20. Thus, the pulmonary tumor was classified stage IV. Chemotherapy based on the combination of cisplatin and etoposide was conducted along with supportive care. The tumor grew up with brain metastases after three cycles of chemotherapy. Unfortunately, the patient died 2 months after despite brain radiotherapy.ConclusionWe presented a medical case of a patient with thyroid metastasis resulting from a pulmonary adenocarcinoma which has rapidly evolved to brain metastases. The prognosis was pejorative in our clinical case (5 months after admission).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lung adenocarcinoma with thyroid metastasis: a case report

Dao

Jabir²,

Taleb³

et al. 2017

BMC Res Notes

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“…Metastatic tumors of the thyroid are not uncommon (48,49). In autopsy series, the overall incidence of thyroid metastasis has been reported as 1.25% and as high as 24% in patients with known extensive disease metastatic to other sites (48,50).…”

Section: Metastatic Thyroid Cancermentioning

confidence: 99%

“…In autopsy series, the overall incidence of thyroid metastasis has been reported as 1.25% and as high as 24% in patients with known extensive disease metastatic to other sites (48,50). In a recent report of a large series, Hegerova et al (49) listed the most common tumor types metastatic to the thyroid as follows: kidney (22%), lung (22%), and head and neck (12%). The role of 18 F-FDG PET/CT in detection of metastatic tumors of thyroid is obscure.…”

Section: Metastatic Thyroid Cancermentioning

confidence: 99%

18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography for Other Thyroid Cancers: Medullary, Anaplastic, Lymphoma and So Forth

Araz

Çayir²

2017

Mirt

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Positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) is used in staging, restaging, and evaluation of therapy response in many cancers as well as differentiated thyroid carcinomas especially in non-iodine avid variants. Its potential in less frequent thyroid tumors like medullary, anaplastic thyroid cancers, thyroid lymphoma and metastatic tumors of the thyroid however, is not well established yet. The aim of this review is to provide an overview on the recent applications and indications of 18F-FDG PET/CT in these tumors and to focus on the controversies in the clinical setting.

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