Metastasis to Paranasal Sinuses from Carcinoma of Prostate: Report of a Case and Review of the Literature

Barbosa, Elio; Ferreira, Evaldo César Macau Furtado; Mariano, Fernanda Viviane; Altemani, Albina; Sakuma, Emerson Taro Inoue; Sakano, Eulália

doi:10.1155/2018/5428975

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…Prior reports have identified the maxillary sinus as the most common site of metastasis, followed by the sphenoid, ethmoid, frontal sinuses, and, finally, the nasal cavity [5,9,11,18,33,34,35]. However, in our study, the nasal cavity was the most common site for metastasis.…”

Section: Discussioncontrasting

confidence: 67%

“…Sinonasal metastases from distant extranasal sites is exceedingly rare. In the literature, nearly half of sinonasal metastases originated from the kidneys, followed by the lungs, breasts, colon, prostate, urogenital ridge, gastrointestinal tract, thyroid, and pancreas (Table 4) [1,5,9,12,13,14,15,16,17,18,19]. In our study, there were four sinonasal metastatic cases originating from the stomach and three cases from the liver, making gastrointestinal adenocarcinoma and hepatocellular carcinoma the top two common primary tumors.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic Tumors of the Sinonasal Cavity: A 15-Year Review of 17 Cases

Chang

Kuo

et al. 2019

JCM

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Extranasal cancers that metastasize to the sinonasal cavity are very rare. To date, there are only limited reports regarding this rare condition within the literature. Therefore, we retrospectively reviewed all patients diagnosed with metastatic cancer of the sinonasal tract from 2003 to 2018 at a tertiary academic medical center. Patient demographic data, clinical presentation, treatment modalities, and outcomes were investigated. There were a total of 17 patients (9 males and 8 females) included in the analysis. The mean age was 56.8 years (range 27–80). The most common primary malignancies were hepatocellular carcinoma (n = 3) and gastrointestinal tract adenocarcinoma (n = 3). The most common site of metastasis was the nasal cavity (n = 8). Five patients received radical tumor resection and the others underwent radiotherapy, chemotherapy, or combined chemoradiotherapy. The 2-year survival was 28%. In summary, metastasis to the sinonasal cavity remains extremely rare. A high degree of suspicion regarding the possibility of metastatic spread to the sinonasal region is necessary for patients with a previous history of malignancy who present with new sinonasal symptoms. The treatment strategy of sinonasal metastatic cancer is usually palliative therapy and the prognosis remains poor. However, early detection and diagnosis, coupled with aggressive treatment, may improve patient quality of life.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Metastatic Tumors of the Sinonasal Cavity: A 15-Year Review of 17 Cases

Chang

Kuo

et al. 2019

JCM

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“…In addition to metastasis from SDC of salivary gland origin, metastatic adenocarcinoma from different organs should always be considered in any sinonasal carcinoma not fitting the common types encountered as this site [ 34 ]. Given the predominance of older males, the major differential diagnostic consideration of primary and secondary sinonasal SDC is metastatic high-grade prostatic adenocarcinoma, as the two entities may share some morphological features and both express the androgen receptor [ 35 ]. In the appropriate clinicopathological context, inclusion of highly sensitive and specific prostate markers such as NKX3.1 is highly valuable compared to the traditional less sensitive prostate markers [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Primary and Secondary/ Metastatic Salivary Duct Carcinoma Presenting within the Sinonasal Tract

Agaimy

Mueller

Bishop

et al. 2021

Head and Neck Pathol

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Traditionally, sinonasal adenocarcinomas have been subdivided into intestinal (ITAC) and non-intestinal (non-ITAC) categories. The latter encompasses salivary-type adenocarcinomas originating from the seromucinous glands of the sinonasal mucosa and non-salivary adenocarcinomas. The non-salivary adenocarcinoma category is further subdivided into low-and high-grade variants. Among salivary-type sinonasal adenocarcinomas, tumors recapitulating salivary duct carcinoma (SDC) are exceedingly rare, but some might have been lumped into the high-grade non-ITAC category. To date, only three primary SDCs originating in the sinonasal tract have been reported. We herein describe 7 cases of SDC including one previously reported case (4 primary sinonasal, 3 metastatic/ extension from parotid gland SDC). The primary tumors affected 3 males and one female aged 60 – 75. Different sites were involved by the primary tumors while the secondary tumors affected the sphenoidal (2) and the frontal + maxillary (1) sinuses. Three primary tumors were de novo high-grade SDC and one was confined to contours of a pre-existing pleomorphic adenoma. All 3 secondary tumors were SDC ex pleomorphic adenoma of the parotid with a long history of recurrences, ultimately involving the sinonasal tract. Androgen receptor was positive in 7/7 cases. Four of 6 cases were strongly HER2/neu + (either score 3 + or with verified amplification). This small case series adds to the delineation of primary sinonasal SDC highlighting that almost half of invasive SDC presenting within sinonasal tract indeed represents extension or metastasis from a parotid gland primary. There is a tendency towards overrepresentation of HER2/neu-positive cases in both categories (primary and metastatic), but this needs clarification in larger studies.

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