Metástasis ósea en el pie como presentación clínica de un carcinoma suprarrenal

Uncommon Metastasizing Site of Adrenocortical Carcinoma

“…Occasional vacuolated cytoplasm, multinucleated tumor giant cells, mitotic figures, and traversing fibrovascular tissue fragments are also reported [7,8]. The lung, liver, and regional lymph nodes are the common metastatic sites while bone involvement mainly in the pelvis is infrequent [1][2][3][4][5]. Patients with BM may present with bone pain, pathological fractures, hypercalcemia, and spinal cord and nerve root compressions [1,6].…”

“…Adrenocortical carcinoma (ACC) is an uncommon, aggressive malignant tumor with an incidence of 0.5-2.0 cases per million inhabitants per year [1][2][3]. ACC has a bimodal age distribution, with small peaks in the first decades and a larger peak in the fourth to fifth decades of life [2,3].…”

“…Adrenocortical carcinoma (ACC) is an uncommon, aggressive malignant tumor with an incidence of 0.5-2.0 cases per million inhabitants per year [1][2][3]. ACC has a bimodal age distribution, with small peaks in the first decades and a larger peak in the fourth to fifth decades of life [2,3]. Patients with functional ACC may present with excess steroid hormone production resulting in Cushing syndrome with or without virilization [2,3], while non-functional ACC patients may present with either symptoms related to tumor mass, such as abdominal discomfort, nausea, vomiting, and back pain, or discovered incidentally during radiological procedures [2,3].…”

“…Patients with functional ACC may present with excess steroid hormone production resulting in Cushing syndrome with or without virilization [2,3], while non-functional ACC patients may present with either symptoms related to tumor mass, such as abdominal discomfort, nausea, vomiting, and back pain, or discovered incidentally during radiological procedures [2,3]. About one-fourth of ACC can present with metastases at the time of diagnosis [3]. The lung, liver, and lymph node are the common sites of metastasis [1][2][3].…”

“…About one-fourth of ACC can present with metastases at the time of diagnosis [3]. The lung, liver, and lymph node are the common sites of metastasis [1][2][3]. Bone metastases (usually at pelvic bone and spinal bone) are infrequent and may present with fractures, spinal cord compression, or hypercalcemia [1][2][3].…”