Metastasis of Uveal Melanoma in Bladder: Presentation of Two Cases and Review of the Literature

Metastatic melanoma to the urinary bladder with synchronous or metachronous metastasis to other organs: Clinicopathological characteristics and outcome

“…Bladder metastases is uncommon and frequently goes undetected [ 9 ]. The gross hematuria is typically the first symptom present in clinical cases [ 1 , 2 , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] ], although urinary retention, dysuria, increased urination frequency, flank pain, and suprapubic pain have been documented in rare circumstances. However, some melanoma cases that metastasize to the bladder are not clinically present.…”

“…It has a bad prognosis. <30 cases of metastatic melanoma to the bladder have been reported in the English literature to date; 5 of these cases were recognized, and 62 reported cases were combined to create the literature study [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] ]. The presented case is the 63rd.…”

“…The presented case is the 63rd. The hematuria or symptoms of the lower urinary tract are the primary complaints when it happens [ 1 , 2 , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] ]. However, the metastases to the bladder were found in 18.0–37.0 % of the individuals with extraregional illness in the autopsy collection.…”

Role of long non-coding RNA ELFN1-AS1 in carcinogenesis

“…Downregulation of E-cadherin is one of the characteristics of EMT, which disrupts adherens junctions. Additionally, overexpressed vimentin, which is involved in the cytoskeleton, contributes to EMT [ 65 – 68 ]. Jinxi Huang et al, Gang Ma et al, and Liyang Dong et al performed similar experiments on stomach, pancreas, and colon cancers to investigate whether ELFN1-AS1 could alter the EMT process.…”