Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study

Abstract

BackgroundMalignant parotid tumors are rare metastases originating from nasopharyngeal carcinoma (NPC). This study aimed to investigate the clinicopathological features and outcome of patients with metastasis of NPC to parotid lymph nodes after surgical therapy.MethodsWe enrolled 14 NPC patients who had metastatic disease to parotid lymph nodes after IMRT. They received surgical treatment by total parotidectomy with neck dissection, superficial parotidectomy with neck dissection, partial parotidectomy with neck dissection, total parotidectomy, or superficial parotidectomy. Their age, gender, histopathology, clinical findings, and treatment outcome were analyzed.ResultsAfter radiotherapy, parotid metastasis represented as uncontrolled disease in three cases and as recurrent disease in 11 cases. All the 14 patients received salvaged surgery successfully. Pathologic findings showed grade 3 in most patients. The follow-up ranged from 11 to 120 months and the overall three- and five-year survival was 49.5% and 37.1%, respectively.ConclusionsMetastasis to parotid lymph nodes should be examined in NPC patients after IMRT. Resection of the inferior parotid lymph nodes is recommended for patients with cervical metastasis, and superficial or total parotidectomy and adjuvant therapy are recommended for intraparotid lymph node metastasis.

Intraparotid lymph node metastasis from a nasal septal carcinoma: an unusual source of the unknown primary

“…Metastatic disease to the parotid lymph nodes typically originate from head and neck lesions, with numerous large case series clearly establishing the clinical outcomes from cutaneous (SCC and melanoma) and mucosal (oropharyngeal) primary sites 12 13. Although there are no reported cases arising from the nasal septum, there are several documented incidents of nasopharyngeal SCC metastasising to the parotid gland 14–17. Despite there being no general consensus on the definitive management of these lesions, they all share a similar initial surgical intervention to our case including parotidectomy with or without neck dissection.…”

BHX Inhibits the Wnt Signaling Pathway by Suppressing β-catenin Transcription in the Nucleus

“…Down-regulating the nuclear β-catenin reduces the interaction of β-catenin and TCF/LEF, thereby suppressing the Wnt signaling pathway24. Herein, we also showed that the suppression of the nuclear translocation of β-catenin resulted in the down-regulated expression of cyclin D1 and c-myc, which were downstream oncogenes of the Wnt/β-catenin signaling pathway2526. Cyclin D1 participates in the phase transitions of the cell cycle by phosphorylating the retinoblastoma protein.…”

Redox Imbalance in the Development of Colorectal Cancer

“…For example, a direct relation among oxidative stress, DNA damage and elevated frequency of p53 mutation in CRC has been observed 23 . Most extensively studied endogenous DNA damage by ROS is the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) 31 . As the biomarker of oxidative stress, 8-oxodG level is higher in colorectal tumors than in normal mucosa 31 .…”

“…Most extensively studied endogenous DNA damage by ROS is the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) 31 . As the biomarker of oxidative stress, 8-oxodG level is higher in colorectal tumors than in normal mucosa 31 . Moreover, increased 8-oxodG is also found in leukocytes and urine of CRC patients 32 .…”