Metastasis of Hepatocellular Carcinoma to the Esophagus: Case Report and Review

Abstract

A follow-up endoscopy in a 71-year-old Japanese man who had undergone a left lateral segmentectomy for HCC two years ago revealed an approximately 2 cm in diameter pedunculated polypoid mass in the middle part of the thoracic esophagus. Immunohistochemical staining of the endoscopic biopsy revealed a metastatic HCC esophageal tumor. As the patient's disease could be radically removed by preoperative examinations, we resected the metastatic esophageal tumor via right thoracotomy and esophagogastrostomy reconstruction. Histological examination of the resected specimen revealed that the esophageal tumor was compatible with a HCC metastasis. This is an extremely rare case of a solitary metastasis to the esophagus from HCC in the literature.

Breast Metastasis in a Patient with Primary Hepatocellular Carcinoma

“…Harada et al, reported a case of asymptomatic oesophageal metastasis, found on routine basis, in a patient with hepatocellular carcinoma, that underwent an oesophagectomy with thoracotomy and the biopsy showed metastasis from hepatocellular carcinoma, whereas, Salimon et al, reported a case of symptomatic oesophageal metastasis in a patient with hepatocholangiocarcinoma and dysphagia. The patient was treated with chemotherapy, contrary with the previous one [6,10]. Nugroho and Serra et al, reported cases of adrenal gland metastases from primary hepatocellular carcinoma, diagnosed with CT-guided biopsy, that were treated with chemotherapy [11,12] whereas, Zhigui Li et al, reported a case of a patient with multiple ectopic liver tissues along the pancreas, with development of hepatocellular carcinoma on these [15].…”

“…The incidence of hepatocellular carcinoma varies among geographical areas, with greater incidence being found in Asia, Taiwan, Korea, China and Japan [1][2][3][4][5][6][7]. Advanced hepatocellular carcinoma is one of the most lethal diseases and includes metastases to various organs, such as lungs, lymph nodes, musculoskeletal structures, peritoneal surface, gastrointestinal tract, spleen and pancreas [7][8][9][10].…”

“…Advanced hepatocellular carcinoma is one of the most lethal diseases and includes metastases to various organs, such as lungs, lymph nodes, musculoskeletal structures, peritoneal surface, gastrointestinal tract, spleen and pancreas [7][8][9][10]. It has only few systematic therapeutic options, with Sorafenib, being the most important pos administered molecular drug, that increases overall survival by approximately 3 months (10.7 months) compared with placebo (7.7 months) [6].…”

“…Hepatocellular carcinoma (HCC), is the 4 th most common neoplasm in men and 9th most common neoplasm in women, making it one of the leading causes of cancer-related deaths (approximately 600.000 deaths/year worldwide) [1][2][3][4][5][6][7][8][9][10][11][12]. Its geographical distribution varies according to the prevalence of known aetiologic factors such as HBV, HCV infection, alcohol, cirrhosis [12].…”

Metastasis of Renal Cell Carcinoma Causing Significant Facial Asymmetry

“…Metastases to the oral cavity or head and neck region are extremely rare conditions [7, 9]. Metastatic tumors account for less than 1% of all oral malignancies [7, 10].…”