Metastasis of carcinoid to the arch of the axis in a multiple endocrine neoplasia patient: a case report

Tanabe, Michiharu; Akatsuka, Keiichi; Umeda, Seiichi; Shomori, Kohei; Taniura, Seijiro; Okamoto, Hisayo; Kamitani, Hideki; Watanabe, Takashi

doi:10.1016/j.spinee.2007.06.015

Cited by 18 publications

(14 citation statements)

References 13 publications

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“…15 In particular, 68 Ga-DOTA-NOC shows the broadest SSR affinity binding to SSR2, SSR3, and SSR5 and seems to be especially accurate in the detection of bone metastases from well-differentiated NETs. 15 To our knowledge, only 45 cases, including ours, of spinal cord compression due to metastases of well-differentiated NETs or to the very rarely occurring primary carcinoid tumors of the CNS [16][17][18][19][20] have been reported in the literature. We excluded spinal paragangliomas-often occurring as intradural extramedullary lesions-because they have been widely reported in the literature.…”

Section: Discussionmentioning

confidence: 77%

“…42 Most of the cases (n = 35) are in fact extradural spinal cord compressions due to vertebral metastases with an epidural soft tissue component. 16,19,[21][22][23][24][25][26]29,[32][33][34][35][36][37][38][39]41,43 Reported cases include carcinoid tumors (n = 36), pNET (n = 6), and NETs of unknown primary (n = 3). Carcinoid tumors were of bronchial (n = 9) and nonpulmonary origin (n = 17)-of which CNS (n = 2) and thymus (n = 3)-, and 4 patients had carcinoid tumors of unknown primary, whereas in 7 patients, the origin was not specified.…”

Section: Discussionmentioning

confidence: 99%

“…Carcinoid tumors were of bronchial (n = 9) and nonpulmonary origin (n = 17)-of which CNS (n = 2) and thymus (n = 3)-, and 4 patients had carcinoid tumors of unknown primary, whereas in 7 patients, the origin was not specified. [16][17][18][19][20][21][22][23][24][26][27][28][29][30][31][32]34,35,37,38,43 Only 6 pNET cases, including ours, of malignant spinal cord compression have been reported in the literature, 25,33,36,40,41 with two of them due to "functional" pNETs (ie, glucagonoma, gastrinoma). As far as we know, our case is the first ever reported of a pNETwith an "intradural" metastasis to the spinal cord, and we only found the following 4 other cases of spinal intradural NET metastases: 2 thymic carcinoids, 28,35 1 lung atypical carcinoid, 18 and a probable primary atypical carcinoid of the CNS.…”

Section: Discussionmentioning

confidence: 99%

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C8-T1 Radiculopathy Due to an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor

et al. 2016

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Pancreatic neuroendocrine tumors (pNETs) are usually well-to-moderately differentiated neuroendocrine tumors (NETs) that most often metastasize to the liver and lymph nodes with other locations being uncommon. We present a case of intradural pNET metastasis and conduct a review of the literature. Forty-five cases, including the case presently reported, of spinal cord compression due to well-differentiated NETs were found: carcinoid (80%), pNET (13.3%), and NETs of unknown primary (6.7%). Seventy-eight percent of cases consisted of extradural compressions from vertebral bone metastases, whereas there were only 5 cases of intradural extramedullary spinal cord compression. Most cases were managed with surgery and/or radiotherapy with a good clinical outcome in the majority. We report the first case of a pNET intradural extramedullary metastasis and conduct the largest review to date of an infrequent complication of well-differentiated NETs such as malignant spinal cord compression. Aggressive local treatment is warranted in most cases because it usually achieves neurologic improvement and symptomatic relief in patients who may still have a long life expectancy.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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C8-T1 Radiculopathy Due to an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor

et al. 2016

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“…Even if patients do not complain of any symptoms, patients with carcinoid tumors should be followed up carefully using effective inspection methods. We reviewed 50 cases that described skeletal metastasis from carcinoid tumors (3,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). The characteristics of the reported patients are shown in Table Ⅰ.…”

Section: Discussionmentioning

confidence: 99%

Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

et al. 2012

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Abstract. Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Skeletal metastases from carcinoid tumors are considered to be extremely rare. In this study, we present two cases of carcinoid tumors that metastasized to the bone. Furthermore, we review 50 published case reports and reveal the features of skeletal metastasis of carcinoid tumors. The first case involved a 59-year-old man with a history of multiple metastases of a lung carcinoid tumor. The patient complained of back pain and numbness in the lower limbs. Magnetic resonance imaging revealed metastases in the thoracic spine. A spinal decompression was performed and the symptoms were resolved. The second case involved a 74-year-old man had been diagnosed with a lung carcinoid tumor 15 years previously and complained of left thigh pain. A radiograph showed osteolytic lesions in the shaft of the left femur. We repaired the femur using an intramedullary nail following curettage of the tumor. A radiograph of the femur revealed a callus on the pathological fracture. The patient was able to walk using a crutch 3 months after surgery. We reviewed 50 cases that described skeletal metastasis from carcinoid tumors. The average age of the patients was 54.9 years and 33 patients (66%) were male. The most common site of skeletal metastasis was the spine. We also investigated the survival rate of patients who developed skeletal metastasis from carcinoid tumors. The findings showed that survival of patients who developed osteolytic skeletal metastasis was worse than that of patients who developed osteosclerotic skeletal metastasis.

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“…48,50,51 Recently, a spinal metastasis of a carcinoid tumor has been also reported in a patient with MEN1. 52 On the other hand, bronchial carcinoids are more prevalent in women than in men. Bronchial carcinoids, often multicentric, may exhibit both synchronous and metasynchronous occurrence.…”

Section: Risk Of Malignant Progressionmentioning

confidence: 99%

Multiple endocrine neoplasia type 1 (MEN1): Not only inherited endocrine tumors

Falchetti

Marini

Luzi

et al. 2009

Genetics in Medicine

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Metastasis of carcinoid to the arch of the axis in a multiple endocrine neoplasia patient: a case report

Cited by 18 publications

References 13 publications

C8-T1 Radiculopathy Due to an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor

C8-T1 Radiculopathy Due to an Intradural Extramedullary Metastasis of a Pancreatic Neuroendocrine Tumor

Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

Multiple endocrine neoplasia type 1 (MEN1): Not only inherited endocrine tumors

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