Metastasis of cancer to cancer: Report of a case of esophageal carcinoma metastasizing to early gastric cancer

Abstract

A rare case of esophageal carcinoma metastasizing to early gastric cancer is reported herein. A 66 year old man who had experienced dysphagia for 8 months was preoperatively diagnosed as simultaneously having esophageal and gastric cancers. Thus, a lower esophagectomy and total gastrectomy with paraesophageal and paragastric lymph node dissection were performed. The surgical specimen revealed an ulcerative tumor in the lower esophagus and a slightly depressed lesion with a central elevation similar to that of early type IIc + IIa gastric cancer in the upper part of the stomach. Microscopically, the esophageal tumor was revealed to be well differentiated squamous cell carcinoma while the gastric tumor was found to be early gastric cancer with a metastatic focus of esophageal cancer in the center. Though less than one hundred cases of metastasis of cancer to cancer have previously been reported, metastasis from cancer of one digestive organ to that of another digestive organ is very rare. To our knowledge, this report represents the first case of an esophageal carcinoma metastasizing to a gastric carcinoma.

Endometrial metastasis of colorectal cancer with coincident endometrial adenocarcinoma

“…This may represent concurrent metastasis of a colorectal carcinoma to a de novo endometrial tumour or it is possible that the endometrial primary had provided a fertile site for metastasis. This idea has been suggested before in sites of cancer,9 10 chronic inflammation, high cell turnover11 or local immunosupression by tumours,10 12 although there are no reports of this in the female genital tract, making this case unusual. It is also possible that the colorectal metastasis may have induced an endometrial carcinoma.…”

Esophageal Adenocarcinoma Metastasizing to a Solitary Fibrous Tumor: An Unprecedented Case of Tumor-to-tumor Metastasis

“…Lu et al report a case of esophageal cancer TMT to an intracranial paraganglioma, treated with a primary resection of the paraganglioma and palliative radiotherapy after discovery of the esophageal malignancy (2). Koyama et al report a case of esophageal cancer TMT to gastric cancer, which was treated with primary resection of both lesions (3). The implications of TMT on the staging of the primary tumor, especially within the setting of esophageal cancer -a malignancy known for its invasive nature and poor prognosis, remain unclear.…”