Metastasis of Breast Cancer to Intracranial Meningioma

Watanabe, Takuya; Fujisawa, Hironori; Hasegawa, Mitsuhiro; Arakawa, Yasuaki; Yamashita, Junkoh; Ueda, Fumiaki; Suzuki, Masayuki

doi:10.1097/00000421-200208000-00019

Cited by 47 publications

(26 citation statements)

References 16 publications

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“…In addition, the slow growth of meningioma may serve as a noncompetitive metabolic environment. 8 Breast cancer and meningioma occur commonly in females in their fifth and sixth decades. Estrogen and progesterone receptors are often expressed, not only in breast tumors, but also in meningiomas, 13 and the similar hormonal background may enhance metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Most papers published on this subject have been case reports or a small case series, [2][3][4][7][8][9][10][11] and the clinical features and distinctive radiological characteristics of this condition have not been described in detail. There are few case reports of cancer metastasizing to an intracranial meningioma; however, only two cases of metastasis to a spinal meningioma appear in the literature.…”

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confidence: 99%

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Breast carcinoma metastasis to meningioma in the thoracic spine: A case report and review of the literature

Okada¹,

Nakamura²,

Koshida³

et al. 2014

The Journal of Spinal Cord Medicine

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Context: Systemic metastasis to a primary tumor of the central nervous system is uncommon. Breast carcinomas metastasizing to a possibly preexisting meningioma in the spine are reported very rarely. Study design: Case report. Findings: A 69-year-old female was referred to us with progressive gait disturbance. She had undergone a total mastectomy for carcinoma of the right breast 11 years previously. A magnetic resonance imaging of the thoracic spine showed an intra-and extradural spinal cord tumor. The patient underwent resection of the tumor via laminectomy from T2 to T4. After the operation, the patient's neurological status improved significantly, and she was able to walk without assistance. Histological examination showed the tumor to be a fibrous-type meningioma within a metastatic breast cancer tumor. The patient underwent 40 Gy radiation treatment for local control of the tumor. However, the tumor recurred locally 7 months after the surgery. The patient died of carcinomatous pleurisy 13 months after the surgery. Conclusion: This case illustrates that a primary meningioma in the thoracic spine can be a recipient of breast cancer metastasis, which may alter the treatment strategy.Keywords: Breast carcinoma, Metastasis, Meningioma, Thoracic spine ContextAdvanced cancer metastases to a central nervous system tumor are rare. When it happens, the metastatic tumor is most often a meningioma.1-11 Several hypotheses explaining the mechanism of distant metastases to a pre-existing central nervous system tumor have been proposed, and include the rich vascularity of the preexisting tumor or hormonal or immunologic factors, but the underlying mechanism remains unclear. Most papers published on this subject have been case reports or a small case series, 2-4,7-11 and the clinical features and distinctive radiological characteristics of this condition have not been described in detail. There are few case reports of cancer metastasizing to an intracranial meningioma; however, only two cases of metastasis to a spinal meningioma appear in the literature. 2,9 Here, we present the very rare case of breast cancer metastasis to a possibly preexisting thoracic meningioma. Case presentationA 69-year-old female was referred to our department with a 1-month history of progressive gait disturbance and back pain. The patient had undergone total mastectomy for carcinoma of the right breast (T2N0M0: stage IIA) 11 years previously. Histological examination had revealed the breast cancer to be invasive ductal carcinoma. Estrogen and progesterone receptors were negative. The patient was treated with four cycles of adjuvant chemotherapy. Seven years after the mastectomy, a chest radiograph revealed a right lung metastasis, and the patient underwent apical segmentectomy to remove the metastatic carcinoma. The lung metastasis had transformed into a metaplastic carcinoma, consisting of malignant bone and cartilage in addition to ordinary ductal carcinoma.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Breast carcinoma metastasis to meningioma in the thoracic spine: A case report and review of the literature

Okada¹,

Nakamura²,

Koshida³

et al. 2014

The Journal of Spinal Cord Medicine

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“…1,4 As me tas ta ses from bre ast can cer are con cerned, in trac ra ni al me nin gi o mas are the most fre quently re por ted re ci pi ent tu mors. 6 The re ha ve be en only fo ur re por ted ca ses of bre ast car ci no ma metas ta tic to RCC, thre e of which be ing au topsy cases. 1 Alt ho ugh this oc cur ren ce is very ra re, his to pat ho lo gic di ag no sis of in va si ve duc tal car cino ma me tas ta tic to con ven ti o nal RCC might not ca u se dif fe ren ti al di ag nos tic dif fi culty du e to the overt dif fe rent morp ho logy of the two tu mors.…”

Section: Discussionmentioning

confidence: 99%

Tumor to Tumor Metastasis: Lobular Carcinoma of the Breast Metastatic to Renal Cell Carcinoma and Lipoleiomyoma:Case Report

Sarı¹,

Ermete²,

Sadullahoğlu³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T Tu mor to tu mor me tas ta sis is a well-known but a ra re event. Lung car ci no ma, be ing as a do nor and re nal cell car ci no ma (RCC) ser ving as a re ci pi ent tu mor are the most com monly obser ved tu mor to tu mor me tas ta tis. Re nal cell car ci no ma ser ving as re ci pi ent of me tas ta tic bre ast car ci no ma is very ra re, and to our know led ge only fo ur ca ses inc lu ding thre e au topsy ca ses ha ve been re por ted to da te. He re in, we re port a ca se of a 69-ye ar-old wo man with in va si ve lo bu lar car cino ma of the bre ast that me tas ta sed to RCC and in ter nal ge ni tal or gans inc lu ding right ovary, ute rus and as well as to a be nign tu mor, li po le i om yo ma.K Ke ey y W Wo or rd ds s: : Carcinoma, lobular; neoplasm metastasis; carcinoma, renal cell; breast; uterus Ö ÖZ ZE ET T Tü mör den tü mö re me tas taz ol duk ça iyi bi lin mek le bir lik te na dir bir du rum dur. Tü mör den tü mö re me tas taz ol gu la rın da ak ci ğer kar si no mu en sık ve ri ci tü mör ola rak rol alan, re nal hüc re li karsi nom (RHK) ise en sık me tas taz ka bul eden tü mör ola rak iz len mek te dir. RHK'un me me kar si nom me tas ta zı nın alı cı sı ol ma sı çok na dir olup bil gi le ri mi ze gö re gü nü mü ze ka dar li te ra tür de ra por edilen üçü otop si ol gu su ol mak üze re sa de ce dört ol gu bil di ril miş tir. Bu ma ka le de, 69 ya şın da ki ka dın has ta da, RHK ya nı sı ra sağ over ve ute rus da da hil in ter nal ge ni tal or gan la ra ve ay nı za man da benign bir tü mör olan li po le i om iyo ma me tas taz yap mış me me nin in va ziv lo bü ler kar si nom ol gu su nu li te ra tür ler eş li ğin de sun duk.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Karsinom, lobüler; tümör metastazı; karsinom, böbrek hücreli; meme; uterus T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J M Me ed d S Sc ci i 2 20 01 11 1; ;3 31 1( (6 6) OLGU SUNUMU e tas ta sis of one can cer to anot her one is an unu su al event. Re nal cell car ci no ma (RCC) is the most com mon ma lig nant re ci pi ent tu mor whe re lung car ci no ma is the most fre qu ent do nor si te. Renal cell car ci no ma ser ving as re ci pi ent of me tas ta tic bre ast car ci no ma is very ra re with only fo ur ca ses be ing re por ted to da te.1 On the ot her hand, metas ta sis to the ute rus is not al so com mon and com pri ses less than 10% of all ca ses of me tas ta sis to fe ma le ge ni tal tract.2 He re in, we re port a ca se of an inva si ve lo bu lar car ci no ma (ILC) of the bre ast me tas ta tic to RCC, fe ma le geni tal or gans and to a be nign tu mor, li po le i om yo ma. CA SE RE PORTA 69-ye ar-old wo man pre sen ted with a 3.5 cm mass in her left bre ast to anot her me di cal cen ter. Bi opsy of the mass was per for med and she then un-

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“…The highly vascular architecture, slow growth rate, high collagen and lipid content of meningiomas provide a medium for seeding of tumor cells. Noncompetitive metabolic environment, and cell to cell interaction from hormonal, enzymatic and immunologic aspects have been ascribed [19]. These criteria can also be applied for other recipient tumors.…”

Section: Discussionmentioning

confidence: 99%

Breast Carcinoma Metastasis in Recurrent Myxoid Liposarcoma

Kabukçuoğlu

Tanık

et al. 2008

Pathol. Oncol. Res.

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Tumor to tumor metastasis is a rare, but well recognized entity, most commonly involving a carcinoma metastasis to a benign or low grade mesenchymal tumor. A case of breast carcinoma metastasis in a recurrent myxoid liposarcoma is presented in this study. A 52-year-old female patient with a history of breast carcinoma (70% invasive lobular carcinoma and 30% invasive ductal carcinoma) presented with a mass in the right lumbar region. The excised mass was diagnosed as myxoid liposarcoma. The tumor recurred twice and was reexcised. Microscopic examination of the second recurrence revealed multiple foci of breast carcinoma metastases in myxoid liposarcoma. Immunohistochemical study showed staining for CK19, GCDFP-15, estrogen and progesterone in metastases. Both breast carcinoma metastasis and myxoid liposarcoma were immunoreactive for E-cadherin and beta-catenin. To our knowledge, this is the first reported case of breast carcinoma metastasis in myxoid liposarcoma, and the first occurrence of metastasis in a liposarcoma.

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Metastasis of Breast Cancer to Intracranial Meningioma

Cited by 47 publications

References 16 publications

Breast carcinoma metastasis to meningioma in the thoracic spine: A case report and review of the literature

Breast carcinoma metastasis to meningioma in the thoracic spine: A case report and review of the literature

Tumor to Tumor Metastasis: Lobular Carcinoma of the Breast Metastatic to Renal Cell Carcinoma and Lipoleiomyoma:Case Report

Breast Carcinoma Metastasis in Recurrent Myxoid Liposarcoma

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