Metastasis mimicking lesion on 18F-FDG-PET CT after application of fibrinogen sponge at site of previous hepatectomy – A report of two cases

Abstract

Intrahepatic cholangiocarcinoma (ICC) is a fatal disease because of frequent recurrence and poor survival despite curative surgery. We investigated the indications for surgery, borderline, or non-surgeryin patients with advanced ICC. Method: We retrospectively studied 194 patients with ICC who underwent curative surgery between 2000 and 2014. Prognostic factors for survival are evaluated on univariate and multivariate analyses. Result: The 5-year survival rate was significantly higher in patients without intrahepatic metastasis (IM: 53%) than in patients with IM (14%, p<0.0001). The 5-year survival rate was significantly higher in patients without lymph node metastasis (LNM: 55%) than in patients with LN (25%, p<0.0001). IM and LNM showed significant prognostic factor for survival on multivariate analysis (both, p<0.0001). According to the survival rates with IM and/or LNM, the 5-year survival rates were 61% in patients without IM or LNM, 41% in patients with LNM and without IM, 26% in patients with IM and without LNM, and 0% in patients with IM and LNM. Conclusion: Indication of surgery of patients with ICC can determine based on the IM and LNM.