Metastasis in mixed epithelial stromal tumour of the kidney: a rare presentation

Holkar, Pravin Sambhaji; Jain, Tarun; Kavishwar, Vikas; Pandya, Jayashri Sanjay

doi:10.1136/bcr-2019-229293

Cited by 2 publications

(3 citation statements)

References 10 publications

(7 reference statements)

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“…Stromal cells showed diffuse nuclear ER and PR positivity. Holkar et al 29 also reported a MESTK case of metastatic lymph nodes wherein a 50-year-old woman presented with flank pain. The stromal component consisted of ovoid to plump spindle cells with diffuse nuclear ER and PR positivity.…”

Section: Discussionmentioning

confidence: 99%

Malignant Mixed Epithelial and Stromal Tumor of the Kidney: Report of a Carcinosarcoma Case and an Updated Literature Review

Jia

et al. 2022

Int J Surg Pathol

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Mixed epithelial and stromal tumors of the kidney (MESTK) are rare and recently defined entities that comprise both epithelial and stromal cells. MESTK is mostly benign; however, to date, 18 borderline or malignant cases have been reported. In this study, we report a case of carcinosarcoma exhibiting a large carcinoma and small sarcoma component, and review the relevant literature. The patient was a 59-year-old woman who presented with a large mass in the left kidney having solid and focal cystic components. The patient underwent left radical nephrectomy. The tumor was gray-white and solid-cystic, with a relatively clear boundary. Microscopically, the tumor revealed benign and malignant components. The benign component consisted of multiple tubules, variable-sized cysts lined with benign epithelium, and hyalinized stroma. The malignant component was composed of predominantly small cell neuroendocrine carcinoma and a small quantity of adenocarcinoma, squamous cell carcinoma, and sarcoma. Finally, a diagnosis of the malignant MESTK was made. Certain cases of borderline or malignant transformation of MESTK have been published, so it is important to enhance findings made by other studies.

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Section: Discussionmentioning

confidence: 99%

Malignant Mixed Epithelial and Stromal Tumor of the Kidney: Report of a Carcinosarcoma Case and an Updated Literature Review

Jia

et al. 2022

Int J Surg Pathol

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“…On immunohistochemical profiling, the mesenchymal component of MEST is typically negative for melanocytic markers while displaying smooth muscle differentiation and immune reactivity for ER and PR [ 6 , 13 ]. Positivity for calretinin, cluster of differentiation 10 (CD10), and inhibin has also frequently been noted in prior reported cases and is indicative of steroidogenic origin [ 6 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…These findings provide further evidence of the diversity of these tumors and support the necessity for holistic interpretation of these biphasic neoplasms. Understanding of these tumors is further complicated by recent reports of malignant transformation among MEST, believed to be related to the absence of immune reactivity to ER [ 7 , 12 , 13 ]. Our pathological specimen demonstrated weak reactivity for ER, while the patient had a sister with a diagnosis of RCC within the same calendar year, possibly indicating a greater potential for malignancy.…”

Section: Discussionmentioning

confidence: 99%

An Aggressively Enlarging Benign Mixed Epithelial Stromal Tumor (MEST) of the Kidney

Janes¹,

Harvey²

2022

Cureus

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Renal neoplasms represent a diverse spectrum of tumors with varying degrees of solid and cystic components that often dictate the potential for malignancy. Mixed epithelial stromal tumors (MEST) of the kidney represent an uncommon and heterogenous subset of these tumors, for which there remains a lack of extant literature and a poor degree of relative understanding. Our case represents a typical presentation of this uncommon neoplasm that contains several important differences regarding immunohistochemical staining and familial interplay that contribute to the literature surrounding these tumors.

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Metastasis in mixed epithelial stromal tumour of the kidney: a rare presentation

Cited by 2 publications

References 10 publications

Malignant Mixed Epithelial and Stromal Tumor of the Kidney: Report of a Carcinosarcoma Case and an Updated Literature Review

Malignant Mixed Epithelial and Stromal Tumor of the Kidney: Report of a Carcinosarcoma Case and an Updated Literature Review

An Aggressively Enlarging Benign Mixed Epithelial Stromal Tumor (MEST) of the Kidney

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