Metastasis from Penile Squamous Cell Carcinoma to Brain: A Case Report and Review of Literature

Bansal, Hanish; Chaudhary, A.K.; Batra, Dipesh; Jindal, Rohit

doi:10.1055/s-0037-1601359

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…5-FU dan Cisplatin diberikan dengan infus kontinu 5-FU 800-1000 mg/m 2 /hari intravena pada hari 1-4 atau hari 2-5. 13,14 Dengan Cisplatin diberikan secara IV pada hari ke-1 100 mg/m 2 . Siklus diulang setiap 3-4 minggu.…”

Section: Pendahuluanunclassified

Karsinoma sel skuamosa penis

Mahatma

Wahid

2019

Maj Kedokt Andalas

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Karsinoma sel skuamosa penis merupakan keganasan yang jarang yang mewakili 0,4-0,6% dari semua keganasan pada pria di Amerika Serikat dan Eropa. Di Indonesia, di RS Sardjito pada tahun 2006-2013 didapatkan insiden sejumlah 35 kasus dengan usia rata-rata 56±14,4 tahun. Karsinoma penis sering muncul dengan tampilan klinis adanya lesi yang terlihat dan teraba pada penis, bisa disertai nyeri, adanya sekret, perdarahan, atau bau busuk apabila pengobatan ditunda. Tujuan: Melaporkan kasus karsinoma sel skuamosa penis. Kasus: Dilaporkan kasus laki-laki 58 tahun dengan benjolan dan tukak yang semakin membesar di penis dengan hasil biopsi jaringan Squamous Cell Carcinoma Penis, Keratinized, Well to Moderately Differentiated. Pada pasien dilakukan total penectomy dan perineostomy. Tiga bulan kemudian pasien kembali datang dengan benjolan di lipat paha kanan hingga skrotum kanan yang semakin membesar. CT scan abdomen dengan kontras menunjukkan massa di inguinal kanan meluas sampai ke skrotum kanan dan kiri. Pasien didiagnosis dengan Squamous Cell Carcinoma Penis Stadium IV (T3N3M0) post total penectomy dan perineostomy. Metastasis kelenjar getah bening inguinal pada pasien ini ditatalaksana dengan kemoterapi regimen Cisplatin-5FU. Simpulan: Telah dilakukan dua siklus kemoterapi dengan interval 3 minggu dan hasil menunjukkan adanya respon di mana ukuran benjolan mulai mengecil.

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Section: Pendahuluanunclassified

Karsinoma sel skuamosa penis

Mahatma

Wahid

2019

Maj Kedokt Andalas

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Clinical and Novel Biomarkers in Penile Carcinoma: A Prospective Review

Pekarek

Ortega

Fraile-Martínez

et al. 2022

JPM

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Penile carcinoma is a rare urological neoplasia in men compared to other more common tumors, such as prostate, kidney, or bladder tumors. However, this neoplasm continues to affect a large number of patients worldwide, with developing countries presenting the highest incidence and mortality rates. Important risk factors such as the human papilloma virus, a factor affecting a large number of patients, have been described; however, few studies have evaluated screening programs in populations at risk for this disease, which severely affects the quality of life of older men. The management of these patients is usually complex, requiring surgical interventions that are not without risk and that have a great impact on the functionality of the male reproductive system. In addition, in cases of disseminated disease or with significant locoregional involvement, patients are evaluated by multidisciplinary oncological committees that can adjust the application of aggressive neoadjuvant or adjuvant chemotherapy on numerous occasions without clear improvement in survival. Chemotherapy regimens are usually aggressive, and unlike in other urological neoplasms, few advances have been made in the use of immunotherapy in these patients. The study of serological and histological biomarkers may help to better understand the underlying pathophysiology of these tumors and select patients who have a higher risk of metastatic progression. Similarly, the analysis of molecular markers will improve the availability of targeted therapies for the management of patients with disseminated disease that would benefit prognosis. Therefore, the purpose of this article is to summarize the main advances that have occurred in the development of serological and histological markers and their therapeutic implications in patients diagnosed with penile carcinoma, explaining the limitations that have been observed and analyzing future perspectives in the management of this disease.

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Metastasis from Penile Squamous Cell Carcinoma to Brain: A Case Report and Review of Literature

Cited by 2 publications

References 8 publications

Karsinoma sel skuamosa penis

Karsinoma sel skuamosa penis

Clinical and Novel Biomarkers in Penile Carcinoma: A Prospective Review

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