Metastasis: a question of life or death

Mehlen, Patrick; Puisieux, Alain

doi:10.1038/nrc1886

Cited by 1,636 publications

(1,294 citation statements)

References 83 publications

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“…Similarly, several cancer cell lines have been shown to better survive chemotherapy or radiation-induced cell death when cultured on Fn-coated surfaces (Damiano et al, 1999(Damiano et al, , 2001Aoudjit and Vuori, 2001;Cordes et al, 2003;Korah et al, 2004). The crosstalk between the cell surface a5b1-integrin and Fn leads to the activation of signaling pathways that can induce cell growth and contribute to the development of the metastatic phenotype (Parise et al, 2000;Mehlen and Puisieux, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…β1 TG2 expression and metastasis LS Mangala et al migration, invasion and survival functions (Lipscomb and Mercurio, 2005). On the other hand, the high expression of TG2 in metastatic breast cancer cells may explain their higher apoptotic threshold, an important characteristic of metastatic cancer cells that enables them to withstand not only the microenvironmental stresses such as hypoxia, nutritional depletion and low pH but also any chemotherapy-induced cytotoxic effects (Mehlen and Puisieux, 2006). Indeed, the results reported here supported such a contention by demonstrating the increased resistance of TG2-rich MDA231/cl.16 cells to paclitaxel compared with low TG2-expressing MDA231/cl.9 cells (Figure 3b).…”

Section: Integ β5mentioning

confidence: 99%

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Tissue transglutaminase expression promotes cell attachment, invasion and survival in breast cancer cells

et al. 2006

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Distant metastasis is frequently observed in patients with breast cancer and is a major cause of cancer-related deaths in these patients. Currently, very little is known about the mechanisms that underlie the development of the metastatic phenotype in breast cancer cells. We previously found that metastatic breast cancer cells express high levels of tissue transglutaminase (TG2), but established no direct link between TG2 and metastasis. In this study, we hypothesized that TG2 plays a role in conferring the metastatic phenotype to breast cancer cells. The results obtained suggested that increased expression of TG2 in breast cancer cells contributes to their increased survival, invasion and motility. We further found that TG2 protein in a metastatic breast cancer MDA-MB231 cells was present on the cell surface in close association with integrins b1, b4 and b5. Downregulation of endogenous TG2 by small interfering RNA inhibited fibronectin (Fn)-mediated cell attachment, survival and invasion. Conversely, ectopic expression of TG2 augmented invasion of breast cancer cells and attachment to Fn-coated surfaces. We conclude that TG2 expression in breast cancer cells plays an important role in the development of the metastatic phenotype.

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Section: Discussionmentioning

confidence: 99%

Section: Integ β5mentioning

confidence: 99%

Tissue transglutaminase expression promotes cell attachment, invasion and survival in breast cancer cells

et al. 2006

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“…Great efforts have been taken to decipher this metastatic process. However, the knowledge is quite limited due to its complexity (Mehlen and Puisieux, 2006;Sahai, 2007). It is of critical importance to identify novel players involved in tumor metastasis.…”

Section: Introductionmentioning

confidence: 99%

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway

et al. 2008

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xCT, the functional subunit of the cystine/glutamate transporter xc-system, plays a critical role in the maintenance of intracellular glutathione and redox balance. Disruption of xCT significantly inhibits the growth of a variety of carcinomas, including lymphoma, glioma, prostate and breast cancer. However, the role of xCT in tumor metastasis remains largely unknown. In this study, both xCT þ / þ and xCT À/À melanocytes were used to evaluate the role of xCT in adhesion. xCT activity was suppressed by an inhibitor, sulfasalazine (SASP), or by xCT siRNA in an esophageal cancer cell line, KYSE150. We found that disruption of xCT enhanced homotypic cell-cell adhesion and attenuated cell-extracellular matrix adhesion. SASP significantly inhibited both cell invasion of KYSE150 in vitro and its experimental metastasis in nude mice. Caveolin-1 was upregulated and b-catenin was recruited to the plasma membrane when xCT was deficient, which were followed by the inhibition of b-catenin transcriptional activity. Further study revealed that the upregulation of caveolin-1 and inhibition of tumor cell invasion were mediated by reactive oxygen species-induced p38 MAPK activation. These results first establish the role of xCT in tumor metastasis and implicate a potential target for cancer therapy.

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“…Although metastasis is the major contributor of cancer-related death, the metastatic process is greatly inefficient and only few progressive cancer cells have the skill to form a colony in the distant organs (Fidler 1973;Mehlen and Puisieux 2006;Steeg 2016). Studies have proposed several mechanisms to explain why only a few cancer cells gain metastatic growth and the others are restricted from this growth (Hess et al 2006;Mehlen and Puisieux 2006;Steeg 2016). A recent review article by Patricia Steeg proposed that specific genomic instability may be the fuel used to complete the metastasis to the distant organs, which is lacking in other cellular (Tokuhisa et al 2015) phenotypes (Steeg 2016).…”

Section: Proteome-signatures Of Cancer Exosomes Dictate Cancer Cells mentioning

confidence: 99%

Exosomes in carcinogenesis: molecular palkis carry signals for the regulation of cancer progression and metastasis

Subramanian

Gupta

Sarkar

et al. 2016

J. Cell Commun. Signal.

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Exosomes, which act as biological cargo vessels, are cell-released, phospholipid-enclosed vesicles. In eukaryotic cells, exosomes carry and exchange biological materials or signals for the benefit or detriment to the cells. Thereby, we consider exosomes to be molecular Palkis (carriers). Although exosomes are currently one of the most popularly researched cellular entities, they have remained largely enigmatic and warrant continued investigation into their structure and functions. These membraned vesicles are between 30 and 150 nm in diameter and are actively secreted by all cell types. While initially considered cellular Btrash bags,^recent years have revealed exosomes to be dynamic and multi-functional vesicles that may play a crucial role in cancer development, progression and metastasis. Thereby, they have the potential to be used in development of therapeutic modalities for cancer and other diseases. As more research studies emerge, it's becoming evident that exosomes are released by cells with a purpose and are representatives of certain cell types and disease conditions. Hence, they may also be used as biomarkers for the detection of cancer initiation, progression and organotropic metastatic growth of cancer cells. This review will focus on the recent developments achieved in identifying the role of exosomes in cancer development and progression as well as therapeutic implications. The review will also discuss the pitfalls of methodologies used for the extraction of exosomes.

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Metastasis: a question of life or death

Cited by 1,636 publications

References 83 publications

Tissue transglutaminase expression promotes cell attachment, invasion and survival in breast cancer cells

Tissue transglutaminase expression promotes cell attachment, invasion and survival in breast cancer cells

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway

Exosomes in carcinogenesis: molecular palkis carry signals for the regulation of cancer progression and metastasis

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