Metastasierendes Pankreas-VIPom: Diagnostik und Therapie mit dem Somatostatin-Analogon Octreotid

Scheffold, N; Arnold, R.; Cyran, J

doi:10.1055/s-2008-1055500

Cited by 7 publications

(3 citation statements)

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“…4 High-dose somatostatin analog (eg, octreotide) therapy offers an initial clinical and biochemical response in metastatic VIPomas. 5,9Y11 Although such therapy may allow long-lasting remission of the symptoms associated with VIPoma, it does not arrest tumor progression. 12 Furthermore, clinical relapse is frequent, and achievement of significant tumor shrinkage has been very difficult in these patients.…”

Section: Discussionmentioning

confidence: 99%

“…Somatostatin analogs are approved for the management of the peptide-mediated symptoms associated with VIPoma and carcinoid syndrome. 4,5 When these levels or the symptoms of diarrhea are not responsive to the somatostatin analogs, aggressive surgical and interventional procedures, such as hepatic resection and hepatic artery embolization, can be utilized to reduce hormone levels. Peptide receptor radionuclide therapy (PRRT) has been experimentally evaluated in NETs sine the 1990s with hundreds of patients treated in the United States and European countries.…”

Section: Case Reportmentioning

confidence: 99%

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Multimodality Management of a Polyfunctional Pancreatic Endocrine Carcinoma With Markedly Elevated Serum Vasoactive Intestinal Polypeptide and Calcitonin Levels

Nasir¹,

Gardner²,

Strosberg³

et al. 2008

Pancreas

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We present an unusual case of a 52-year-old woman with severe, uncontrollable, refractory diarrhea attributable to pancreatic endocrine carcinoma (ECA) with markedly elevated serum vasoactive intestinal polypeptide (VIP) and calcitonin levels. After initial correction of fluid and electrolyte abnormalities, the patient was treated with high-dose octreotide. Shortly thereafter, due to the intractable nature of her diarrhea, she underwent cytoreductive hepatic surgery. The pancreatosplenectomy specimen showed a poorly differentiated ECA of the distal pancreas, immunoreactive for synaptophysin, CD56, and S100 protein, with morphologically similar hepatic and lymph node metastases. Postoperatively, her diarrhea improved, along with decline in serum VIP and calcitonin levels. Systemic chemotherapy with etoposide and cisplatin did not result in any radiographic and biochemical improvement. Having radiologically stable disease with depot-octreotide and short-acting octreotide (Sandostatin), she was subjected to peptide receptor radiotherapy with [177Lu-DOTA0,Tyr]octreotate (LuTate) that resulted in marked clinical and biochemical improvement, along with dramatic reduction in the number and size of hepatic metastases. In summary, this is a unique case of metastatic VIP- and calcitonin-secreting pancreatic ECA with dramatic sustained clinical, biochemical, and objective tumor response to peptide receptor radionuclide therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Multimodality Management of a Polyfunctional Pancreatic Endocrine Carcinoma With Markedly Elevated Serum Vasoactive Intestinal Polypeptide and Calcitonin Levels

Nasir¹,

Gardner²,

Strosberg³

et al. 2008

Pancreas

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“…The second case was a VIPoma in the body of the pancreas along with somatostatin receptor scintigraphy revealing a 1.8 cm right ovarian mass. This particular patient was treated with the somatostatin analogue octreotide only [4] . Although systemic options for treatment of PNETs are expanding, surgical cytoreduction remains an important treatment modality [5] .…”

Section: Discussionmentioning

confidence: 99%

Metastatic VIPoma presenting as an ovarian mass

Mark

Bush

Glazer

et al. 2015

International Journal of Surgery Case Reports

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HighlightsAlthough rare, metastatic PNET with disease in the female pelvis should remain in the differential diagnosis in a patient with enlarging ovaries and a history PNET.Metastatectomy is recommended even with disease in the female pelvis and may include bilateral oophorectomy when identified.Metastatic disease is favored when imaging of ovaries demonstrates bilateral tumors and well-circumscribed nodular lesions.Use of somatostatin receptor scintigraphy is helpful to evaluate newly identified distant lesions.

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Klinische Krankheitsbilder durch Störungen der Bildung gastrointestinaler Hormone

Grandt¹,

Goebell²,

Ve³

1997

Endokrinologie Des Kindes- Und Jugendalters

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Metastasierendes Pankreas-VIPom: Diagnostik und Therapie mit dem Somatostatin-Analogon Octreotid

Abstract: This case demonstrates so far successful suppression of a metastasizing VIPoma with the somatostatin analogue octreotide, the metastasis having been revealed first by somatostatin-receptor scintigraphy.

Cited by 7 publications

References 0 publications

Multimodality Management of a Polyfunctional Pancreatic Endocrine Carcinoma With Markedly Elevated Serum Vasoactive Intestinal Polypeptide and Calcitonin Levels

Multimodality Management of a Polyfunctional Pancreatic Endocrine Carcinoma With Markedly Elevated Serum Vasoactive Intestinal Polypeptide and Calcitonin Levels

Metastatic VIPoma presenting as an ovarian mass

Klinische Krankheitsbilder durch Störungen der Bildung gastrointestinaler Hormone

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