Metastases to the thyroid gland: prevalence, clinicopathological aspects and prognosis: a 10‐year experience

Papi, Giampaolo; Fadda, Guido; Corsello, Salvatore Maria; Corrado, Stefania; Rossi, Esther Diana; Radighieri, Elena; Miraglia, Antonella; Carani, Cesare; Pontecorvi, Alfredo

doi:10.1111/j.1365-2265.2007.02773.x

Cited by 185 publications

(280 citation statements)

References 30 publications

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“…Oncological patients represented only 6.3% of that population, in contrast to centres specialising in the diagnosis and treatment of cancers that present many reports on metastases to the thyroid gland [13,[27][28]. Probably for this reason, in our study the percentage of patients with secondary cancer (0.3%) was lower than in typical oncological centres, and similar to that found in centres involved in the diagnosis of thyroid disorders [15,25] and in general centres (non-specialised) [8] (Table IV). Regardless of that fact, our data showed regularity in higher risk of metastasis in patients with malignant disease than in those with negative history of cancer.…”

Section: Prace Oryginalnecontrasting

confidence: 50%

“…Similarly, other authors indicate that metastases to the thyroid gland usually involve people in the 6th-7th decade of life [8,11,14,32]. On the other hand, the youngest patient with metastasis in our study was 25 years old (infiltration of the thyroid was the first sign of cancer), and Pusztaszeri et al showed clear cell sarcoma metastasis in a sevenyear-old child [14].…”

Section: Prace Oryginalnementioning

confidence: 61%

“…After taking into account the relative frequency of metastases (in relation to the number of patients subjected to FNA with a specific cancer) we observed that the dominant type of metastases was a tumour infiltrating the thyroid by direct extension from the neighbouring primary lesion. Also other authors showed that tumours of the head and the neck were the most common [14][15] or frequent [8] source of metastasis. However, most of the authors limited their analyses to metastases from distant organs only.…”

Section: Prace Oryginalnementioning

confidence: 99%

“…Metastases to the thyroid are revealed clinically with a frequency of 0.1-3% in patients diagnosed or operated for thyroid nodules/cancer [1,[7][8][9][10][11][12][13][14][15][16]. Hegerova et al found metastases in 97 out of 10,798 (0.9%) patients identified from a database of cytological material archived over 30 years at the Mayo Clinic [17].…”

Section: Introductionmentioning

confidence: 99%

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Nowotwory wtórne ujawniane podczas BAC tarczycy — analiza częstości występowania i charakterystyka obrazu ultrasonograficznego

Wysocka

Małyska

Zadworny

et al. 2015

Endokrynologia Polska

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Introduction: Metastases to the thyroid are revealed at autopsy with a frequency of 2-24%; however, clinically they appear less frequently, at 0.1-3%. The aim of the study was analysis of the frequency of revealing metastases to the thyroid (TM) and to the regional lymph nodes (NM) (neoplasms other than primary thyroid tumours) in preoperative diagnostics of the thyroid in patients with positive (C+) and negative (C-) history of cancer; analysis of ultrasound (US) images of metastases. Material and Methods: Results of US/fine needle aspiration (FNA) of the thyroid in 1276 C+ patients and 18,947 C-patients. Results: TM and NM were diagnosed/suspected in 57 patients (0.3% of all examined; 40 TM, 22 NM, 5 both), and their frequency was higher in the C+ group (2.9% vs. 0.1% in C-, p < 0.0001). In the C+ group, diagnosis of metastasis accounted for 72.3% of FNA results from the category "malignant neoplasm"; in the C-group it was 9.5% (p < 0.0001). The highest relative frequency of TM was found for cancers infiltrating thyroid by direct extension (> 10%), lymphomas (7.7%), and kidney (5.3%) and lung (4.9%) cancers. The mean age of patients with metastasis (63.9 ± 11.7 years) was similar to that of the C+ group and higher than the C-group (53.9 ± 14.8 years, p < 0.0001). The proportion of males among the patients with metastasis was three-fold higher than in the patients without metastasis (p < 0.0001). TM lesions presented suspicious borders in US twice as often as primary cancers . Conclusions: Metastases to the thyroid are rare; however, for patients with a history of cancer, their presence is more likely than primary thyroid cancer. US/FNA imaging of metastases allows the selection of patients requiring further diagnostics and treatment.

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Section: Prace Oryginalnecontrasting

confidence: 50%

Section: Prace Oryginalnementioning

confidence: 61%

Section: Prace Oryginalnementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nowotwory wtórne ujawniane podczas BAC tarczycy — analiza częstości występowania i charakterystyka obrazu ultrasonograficznego

Wysocka

Małyska

Zadworny

et al. 2015

Endokrynologia Polska

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“…Some studies suggest a higher incidence in females, while others report otherwise (4,12,13). According to their primary site, melanomas are grouped as cutaneous, ocular, mucosal, and of unknown origin; of all, mucosal melanomas are the least frequent ones (14).…”

Section: Discussionmentioning

confidence: 98%

Malignant melanoma with synchronous thyroid metastases: case report and literature review

Belo

Capela-Costa

Costa

et al. 2017

Arch. Endocrinol. Metab.

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SUMMARYThyroid metastases are rare in clinical practice. We describe the case of an 85-year-old woman who was referred to our department due to a multinodular goiter with compressive symptoms and subclinical hyperthyroidism. The patient was also undergoing evaluation for a polyp in her left nasal cavity, which was then diagnosed as a malignant melanoma of the nasal mucosa. A thoracoabdominal magnetic resonance imaging obtained for cancer staging revealed a > 50% tracheal obstruction caused by the goiter. The patient underwent simultaneous total thyroidectomy and melanoma excision. Histological analysis of the thyroid showed the presence of multiple metastatic foci from the melanoma. Due to the patient's age, a decision was made to maintain her under surveillance and administer palliative treatment if necessary. Although metastases to the thyroid are rare, they should be considered in the differential diagnosis of thyroid lesions in patients with a known primary tumor. The thyroidectomy, performed in this patient's case, allowed the diagnosis of the metastases and relief of compressive symptoms caused by the goiter. Arch Endocrinol Metab. 2017;61(2):193-7.

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Pathology Quiz Case 2: Diagnosis

2011

Arch Otolaryngol Head Neck Surg

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Metastases to the thyroid gland: prevalence, clinicopathological aspects and prognosis: a 10‐year experience

Cited by 185 publications

References 30 publications

Nowotwory wtórne ujawniane podczas BAC tarczycy — analiza częstości występowania i charakterystyka obrazu ultrasonograficznego

Nowotwory wtórne ujawniane podczas BAC tarczycy — analiza częstości występowania i charakterystyka obrazu ultrasonograficznego

Malignant melanoma with synchronous thyroid metastases: case report and literature review

Pathology Quiz Case 2: Diagnosis

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