Metastases to the Breast From Extramammary Carcinomas

Nielsen, Maja; Ørnvold, Kim; Andersen, Johan A.; Henriksen, F. W.; Kristensen, Peter B.; Lorentzen, Martin; Ravn, Vibeke; Schiødt, Torben; Thorborg, Jens Vilhelm

doi:10.1111/j.1699-0463.1981.tb00218.x

Cited by 61 publications

(37 citation statements)

References 23 publications

(10 reference statements)

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“…Twelve of these cases were classified as adenocarcinomas (5,9,12,19,(21)(22)(23)25). Additionally, 53 cases of breast metastasis from lung tumors were presented; however, no detailed histological classification was provided (7,18,(28)(29)(30). The majority of breast metastases present as palpable, rapidly growing, well-circumscribed and painless breast masses with predilection to the upper outer quadrant (2,7,17,21,22).…”

Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 99%

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

et al. 2012

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Abstract. Breast metastasis from extra-mammary malignancy is rare. An incidence of 0.4-1.3% has been reported in the literature. The primary malignancies most commonly metastasizing to the breast are leukemia, lymphoma and malignant melanoma. We present a case of metastasis to the breast from a pulmonary adenocarcinoma, diagnosed concomitantly with the primary tumor. A 43-year-old female presented with dyspnea and a dry cough of 3 weeks' duration. A subsequent chest radiograph revealed a massive pleural effusion. Additionally, on physical examination, a poorly defined mass was noted in the upper outer quadrant of the right breast. The patient underwent bronchoscopy, simple right mastectomy and medical thoracoscopy. Following cytology, histology and immunohistochemistry, primary lung adenocarcinoma with metastasis to the breast and parietal pleura was diagnosed. Histologically, both the primary and metastatic anatomic sites demonstrated a micropapillary component, which has recently been recognized as an important prognostic factor. Although the patient received chemotherapy, she succumbed to her condition within 8 months. Accurate differentiation of metastasis from primary carcinoma is very important as the treatment and prognosis of the two differ significantly. IntroductionThe National Cancer Institute of the USA estimates that, based on current rates, 12.7% of females born today will be diagnosed with breast cancer in their lifetime (1). Although primary breast cancer is the most common malignancy of adult females, metastatic involvement of the breast is rare, with a reported frequency of 0.4-1.3% in clinical series (2-5). Despite its rarity, metastatic breast disease is an significant diagnostic clinical problem, as its treatment differs greatly from that of primary breast cancer. In 1907, Sitzentfrey was the first to publish a case of ovarian carcinoma metastatic to the breast (6). To date, a wide variety of malignancies have now been reported to metastasize to the breast and according to the literature, the most common primary tumors are melanomas and haematological malignancies (5-7). The lung is the most common cancer site in terms of incidence and mortality; however, there have only been a few published cases of pulmonary carcinomas metastasizing to the breast (8-12). Carcinomas with micropapillary components have been reported at several anatomical sites, including the breast, urinary bladder, ovary and major salivary glands (13). Micropapillary components are being increasingly recognized as prognostic predictors in lung adenocarcinomas and according to many studies, this may be a manifestation of aggressive behaviour (14,15). We report the case of a patient with breast metastasis from a pulmonary adenocarcinoma characterized by a micropapillary pattern and diagnosed in conjunction with the primary tumor. Written informed consent was obtained from the patient for publication of this case report and accompanying images. Case reportA 43-year-old, non-smoking housewife presented to the Emergency Departme...

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Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 99%

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

et al. 2012

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“…The fact that such cases are rare in males supports this theory, particularly as most of these tumors tend to be metastases from prostatic carcinomas in patients treated with estrogens, which are known to increase the mammary blood fl ow. [14][15][16] Synovial sarcoma originates in the deep soft tissues and primarily appears in close proximity to limb joints. The tumor accounts for 5.6%-10.0% of all soft tissue tumors, and 72% of the patients are younger than 40 years of age.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Breast Tumor Arising from Synovial Sarcoma: Report of a Case

Kijima¹,

Yoshinaka²,

Higashi³

et al. 2007

Surg Today

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We report a case of metastatic breast tumor arising from a synovial sarcoma of the lower limb. A 27-year-old Japanese woman was diagnosed to have synovial sarcoma 14 months prior to finding a mass in her left breast. An excisional biopsy was performed and a metastatic synovial sarcoma to the breast was confirmed. Eight months after the resection of the breast lesion, the patient developed local recurrences in both her knee and breast. A tumor resection of the limb lesion and a simple mastectomy for the huge lesion, which was diagnosed to be a metastatic breast tumor without lymph node metastasis, were performed. After the operation, the patient received adjuvant systemic chemotherapy. To the best of our knowledge, this is only the second reported case of a solitary metastatic breast tumor arising from synovial sarcoma.

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“…Malignant melanoma, lymphoma, lung cancer, ovarian carcinoma, soft tissue sarcoma are the most common cancers to metastasize to breast (8,13,14). Metastases from osteosarcoma, gastric cancer, cervical, vaginal and endometrial carcinomas to the breast were also reported sporadically in the literature (8,(13)(14)(15). To our knowledge this is the fifth case of thyroid cancer and second case of follicular sub-type reported metastasizing to the breast (3-6).…”

Section: Discussionmentioning

confidence: 89%

Follicular Thyroid Carcinoma with Metastases to the Breast: An Unusual Case

Arslan¹,

Çoşkun²,

Göksu³

et al. 2014

J Breasth Health

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A 57-year-old woman was admitted with a left breast mass. Metastatic follicular thyroid carcinoma (FTC) was diagnosed two years previously with excision of a parietal bone lesion. Two sessions of radioactive I-131 were administered after total thyroidectomy due to multiple metastases in the lungs and bones. A regimen of single agent adriamycin was given when the disease progressed. Partial remission was obtained after 6 cycles of chemotherapy. After five months following chemotherapy she was admitted with a left breast mass. Surgical excision revealed FTC metastasis. The patient has a stable disease twelve months after metastasectomy. Metastasis of thyroid cancer to the breast is a very rare occurrence. Only a few cases were reported. It is important to distinguish metastatic malignancies from primary breast tumors to avoid destructive surgery and maintain the appropriate treatment of the primary tumor.Key words: Breast cancer, metastasis, Follicular thyroid cancer ÖZETElli yedi yaşında bir kadın sol memede kitle nedeniyle başvurdu. İki yıl once pariyetal kemik lezyonu eksizyonu ile folliküler tiroid kanseri (FTK) metastazı tanısı almıştı. Total tiroidektomi sonrasında; akciğerlerde ve kemiklerde multipl metastazlarının olması nedeniyle 2 kez radyoaktif iyot 131 uygulanmıştı. Daha sonra hastalık progresyonu nedeniyle tek ajan adriyamisin kemoterapisi başlandı ve 6 kür sonrasında kısmi yanıt elde edildi. Kemoterapi sonlandırıldıktan 5 ay sonra sol memede kitle nedeniyle başvurdu. Memedeki kitle eksize edildi ve patoloji FTK metastazı olarak raporlandı. Metastazektomi sonrasında 12. ayda stabil hastalık ile izlenmektedir. Tiroid kanserinin meme metastazı nadir bir durumdur ve çok az sayıda olgu rapor edilmiştir. Morbiditesi yüksek cerrahi girişimlerden kaçınmak ve primer tü-möre yönelik uygun cerrahi girişimi uygulayabilmek açısından metastatik kanserin primer meme tümörlerinden ayrımı önemlidir. Anahtar sözcükler: Meme kanseri, metastaz, Folliküler tiroid kanseri IntroductionDistant metastases of differentiated thyroid cancer are usually to the lung and bone. Less common sites of metastases are the brain, liver, kidneys, and skin (1, 2). Thyroid cancer metastasis to the breast was reported only in four cases and one of them was follicular sub-type (3-6).Solid tumor metastasis to the breast is rare. 0.43% of breast malignancies were reported as secondary tumors (7). The most common tumors metastasizing to the breast are malignant melanoma, lymphoma and lung cancer (8). Treatment procedures change regarding histopathological diagnosis. In this paper we describe a patient with follicular thyroid cancer developing breast metastasis during the follow up diagnosis and treated with surgical excision. Case ReportA 57-year-old woman was admitted with a left breast mass. Her family history was unremarkable. Twenty six months earlier a parietal bone lesion was excised surgically. Pathology showed follicular thyroid carcinoma (FTC) metastasis. Thyroid ultrasonography showed a solid nodule of 2 cm in diameter in the e...

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Metastases to the Breast From Extramammary Carcinomas

Cited by 61 publications

References 23 publications

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

Metastatic Breast Tumor Arising from Synovial Sarcoma: Report of a Case

Follicular Thyroid Carcinoma with Metastases to the Breast: An Unusual Case

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