Metastases to Meckel's cave: Report of two cases and comparative analysis of malignant tumors with meningioma and schwannoma of Meckel's cave

Soni, Chetan; Kumar, Gyanendra; Sahota, Pradeep; Miller, Douglas C.; Litofsky, N. Scott

doi:10.1016/j.clineuro.2010.07.019

Cited by 12 publications

(20 citation statements)

References 20 publications

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“…Previous reports of malignancies metastatic to the trigeminal cave have included carcinoma of the lung, breast, colon and thyroid, as well as cutaneous melanoma 11. Distant metastasis to the cranial cavity occurs via haematogenous spread, as does metastasis of internal malignancy to the skin.…”

Section: Discussionmentioning

confidence: 99%

Concurrent metastases of papillary thyroid carcinoma to the scalp and Meckel’s cave

Phelan

Mull²,

Rajput

et al. 2018

BMJ Case Reports

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We present the case of a 65-year-old man with severe headaches and unilateral facial weakness, seen in consultation by the dermatology service to rule out primary cutaneous melanoma after brain imaging identified an enlarging mass within the right trigeminal (Meckel's) cave. Examination revealed only a pair of erythematous papules on the scalp, for which biopsy demonstrated metastatic papillary thyroid carcinoma. Further evaluation and subsequent thyroidectomy confirmed the origin of widespread internal disease, followed by definitive excision of scalp lesions and multimodal management of systemic involvement. Whereas presentation of metastasis to the skin is highly variable, a low threshold for biopsy may allow for histological identification of internal disease not otherwise considered in the clinical differential.

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Section: Discussionmentioning

confidence: 99%

Concurrent metastases of papillary thyroid carcinoma to the scalp and Meckel’s cave

Phelan

Mull²,

Rajput

et al. 2018

BMJ Case Reports

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show abstract

“…Nevertheless, only anatomopathological analysis can confirm the diagnosis. 12 Neurological manifestations vary, with non-focal symptoms being the most common presentation. Headaches, altered mental status, memory deficits, double vision associated to 3 rd , 4 th and 6 th cranial nerve palsy, motor deficit and em que foi observado um tumor no cavo trigeminal do lado direito.…”

Section: Discussionmentioning

confidence: 99%

Trigeminal Cave Brain Metastasis from Prostate Adenocarcinoma: Case Report and Review of the Literature

et al. 2018

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The present study presents the case of a 66-year-old patient diagnosed with prostate adenocarcinoma 4 years earlier and treated with prostatectomy, radiotherapy, chemotherapy and hormone therapy but still displaying high prostate-specific antigen (PSA) levels. The patient complaints were double vision and headaches. Upon physical examination, he displayed 6th cranial nerve paresis and 5th cranial nerve paresthesia. A magnetic resonance imaging (MRI) exam was performed, which revealed a mass on the right trigeminal cave. The patient underwent surgical removal of the tumor, and the pathological analysis of the specimen established metastatic prostate cancer as the diagnosis.Brain metastases from prostate cancer are extremely rare and mark advanced disease, with immune system failure and blood-brain barrier breach. Prostate-specific antigen levels do not correlate with the possibility of metastatic disease. Prostate adenocarcinoma is the histologic type most commonly associated with brain metastases, with the meninges being more frequently affected, followed by the brain parenchyma. The neurological symptoms more often displayed are non-focal, such as headaches and mental confusion. Surgery associated with radiotherapy is the most validated treatment.

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“…Very few cases of metastatic involvement of the Meckel's region have been published. On a meta-analysis (2010) of malignant tumors involving this region, Soni RC et al (23) found 20 cases, including theirs, of malignant involvement of Meckel's cave described in the literature. Most primary neoplasm involved were: small cell lung cancer (2 cases), breast cancer (4 cases), adenocarcinoma of colon (2 cases), lymphoma (4 cases), renal cell cancer (1 case) and folicullar thyroid cancer (1 case) (9,13,25).…”

Section: Discussionmentioning

confidence: 99%

“…The last two approaches are especially used in the resection of tumors with important extension in the posterior fossa. In cases of small extranevraxial lesions, such as meningiomas and neurinomas, a safe surgery could be performed only by using an extradural approach (20,23).…”

Section: Discussionmentioning

confidence: 99%

“…In our case, axial MRI T1-weighted images with gadolinium enhancement showed a tumor, which enhances the contrast relatively uniform, located in the left Meckel's cave, extending to the left cavernous sinus without infiltrated it, and down to the cerebello-pontine angle. Differential diagnosis must include meningiomas, neurinomas, epidermoid cysts, metastasis, chordomas, chondrosarcomas and maxillary sinus tumors (23).…”

Section: Discussionmentioning

confidence: 99%

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Surgical treatment of rare metastatic tumor in Meckel’s Cave: a case report

Rădoi¹,

Stefanescu²,

Vakilnejad³

et al. 2017

Romanian Neurosurgery

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Abstract:Objectives: Metastases in Meckel's cave are a rare tumor entity, but they should be considered in patients with a known primary malignancy and who complain of trigeminal neuralgia. Methods: The case of a patient with a left trigeminal neuralgia caused by a metastatic tumor involving the Meckel's cave and Gasserian ganglion is reported. Preoperative symptoms included headache, trigeminal hyperesthesia and facial pain. Results: The patient underwent microsurgical resection of the tumor, obtaining a histological diagnosis and a resolution of the pain. Trigeminal motor function was preserved. Conclusion: The best treatment for tumors of Meckel's cave, including metastases, is complete microsurgical removal. Although good results have been reported with radiosurgery, this treatment should be reserved only for nonresectable and residual tumors.

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Metastases to Meckel's cave: Report of two cases and comparative analysis of malignant tumors with meningioma and schwannoma of Meckel's cave

Cited by 12 publications

References 20 publications

Concurrent metastases of papillary thyroid carcinoma to the scalp and Meckel’s cave

Concurrent metastases of papillary thyroid carcinoma to the scalp and Meckel’s cave

Trigeminal Cave Brain Metastasis from Prostate Adenocarcinoma: Case Report and Review of the Literature

Surgical treatment of rare metastatic tumor in Meckel’s Cave: a case report

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