Metastases to lymph nodes of the head and neck from an unknown primary site

Coker, Donald D.; Casterline, Peter F.; Chambers, Robert G.; Jaques, Darrell A.

doi:10.1016/0002-9610(77)90390-7

Cited by 92 publications

(32 citation statements)

References 10 publications

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“…Several studies showed that the subsequent detection of a primary tumor was associated with a worse prognosis [5,12,23]. In the literature, 5-year appearance rates of subsequent head and neck primary tumors vary from 2% to 54% (Table 3).…”

Section: Extent Of Radiotherapy and Toxicitymentioning

confidence: 99%

“…Several prognostic factors in neck metastases from a CUP have been described: extracapsular extension [6,24,35], surgery/resection status [10,21,23,30], nodal status [5,6,12,15,23,24,33], histological grading [12,33], appearance of a subsequent primary tumor [5,12,23], nodal fixation [24], tumor localization [21], and pretherapeutic hemoglobin level [15].…”

Section: Prognostic Factorsmentioning

confidence: 99%

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Neck Lymph Node Metastases from an Unknown Primary Tumor

et al. 2005

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Section: Extent Of Radiotherapy and Toxicitymentioning

confidence: 99%

Section: Prognostic Factorsmentioning

confidence: 99%

Neck Lymph Node Metastases from an Unknown Primary Tumor

et al. 2005

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“…Most likely, this was due to selection of patients with more favorable nodal stage for surgery alone and those with more advanced nodal disease for adjunctive radiotherapy. Combining data of surgery alone from four available series [2••, [15][16][17], however, revealed a crude mucosal carcinoma emergence rate of approximately 25% (30 of 121 patients), a median nodal recurrence rate of approximately 34%, and a 5-year overall survival rate of approximately 66%. These sets of data suggest that selected patients, particularly those with pN1 neck disease with no extracapsular extension, can be treated adequately with surgery alone [16].…”

Section: Treatmentmentioning

confidence: 94%

Cervical lymph node metastases from occult squamous cell carcinoma

Nieder

Ang

2002

Curr. Treat. Options in Oncol.

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Depending on patient and tumor characteristics, reported 5-year actuarial survival rates of patients with cervical nodal metastasis from an unknown primary carcinoma range from 18% to 63%. Prognostic factors for survival include N-stage, number of nodes, grading, extracapsular extension, and performance status. Retrospective studies suggest that neck relapse is more common than are distant metastases or emergence of mucosal primary tumors. The treatment options include neck dissection alone, radiation alone to the neck with or without the putative mucosal origin, and combination unilateral neck dissection plus limited or comprehensive radiotherapy. Combination of nodal dissection with comprehensive bilateral radiotherapy yielded most favorable results in local-regional disease control. However, its impact on the quality of life should be recognized. Also, the confounding effects of patient selection for various treatment modalities on therapeutic outcome cannot be quantified. Retrospective single-institution comparisons between comprehensive and unilateral neck radiotherapy did not show apparent differences in outcome. A randomized trial to compare the therapeutic value of comprehensive versus volume-limited radiotherapy is being planned. No data were found to support the benefit of chemotherapy for the treatment of this disease.

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“…Lymph node metastases of carcinomas of an unknown primary are responsible for 3-5% of the malignant diseases in the head and neck area [2,3]. Approximately 37% of CUP syndrome metastases manifest initially in the lymph node system of the body.…”

Section: Introductionmentioning

confidence: 99%

Value of Neck Dissection in Patients with Squamous Cell Carcinoma of Unknown Primary

Werner

Dünne²

2001

Oncol Res Treat

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Lymph node metastases of cancer of an unknown primary (CUP syndrome) are responsible for 3–5% of the malignant diseases in the head and neck area. More than 70% of these patients show lymph node metatases of an unknown squamous cell carcinoma. The survival depends immediately on number and location of lymph node metastases. For a curative approach modified radical neck dissection combined with postoperative radiation therapy with or without chemotherapy should be considered in N1–N3 lymph node status. A radical neck dissection with postoperative radiation therapy should only be approved in cases of infiltration of the internal jugular vein, the accessory nerve and/or the sternocleidoid muscle. The different prognosis of patients with upper cervical and lower cerival lymph nodes should influence the indication and the extent of a neck dissection in the contralateral N0 neck.

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Metastases to lymph nodes of the head and neck from an unknown primary site

Cited by 92 publications

References 10 publications

Neck Lymph Node Metastases from an Unknown Primary Tumor

Neck Lymph Node Metastases from an Unknown Primary Tumor

Cervical lymph node metastases from occult squamous cell carcinoma

Value of Neck Dissection in Patients with Squamous Cell Carcinoma of Unknown Primary

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