Metastases to and from the Lung

Dail, David H.

doi:10.1007/978-0-387-72114-9_13

Cited by 7 publications

(7 citation statements)

References 260 publications

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“…This phenomenon can be explained in terms of presence of certain features like: 1) they continuosly receive the entire right-sided cardiac output with every heartbeat; 2) they are the first capillary plexus met by cells after most of the lymphatic drainage enters the venous system; and 3) they consist of delicate membranes that may be beneficial for initially drawing on nearby oxygenated air for early sustenance. 8 However, lung carcinoma is one of the rarest recipients for tumor-to-tumor metastasis. RCC is the most common recipient tumor in tumor-to-tumor metastasis.…”

Section: Discussionmentioning

confidence: 99%

Papillary Carcinoma of Thyroid Metastatic to AdenocarcinomaIn Situof Lung: Report of an Unusual Case

Kim

Chu

et al. 2012

Korean J Pathol

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The tumor-to-tumor metastasis is a rare event. The lung tumors are the most common donor tumors in tumor-to-tumor metastasis, but are exceedingly rare as a recipient. Here, we report a case of papillary thyroid carcinoma (PTC) metastasizing to adenocarcinoma in situ (AIS, formerly bronchioloalveolar carcinoma) of the lung in a 44-year-old woman who underwent total thyroidectomy for PTC 8 years ago. To the best of our knowledge, the present case is the first case reporting on PTC metastasized to AIS. A review of the relevant literature is presented.

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Section: Discussionmentioning

confidence: 99%

Papillary Carcinoma of Thyroid Metastatic to AdenocarcinomaIn Situof Lung: Report of an Unusual Case

Kim

Chu

et al. 2012

Korean J Pathol

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“…Five features of the pulmonary system have been identified that may contribute to the heightened incidence of such metastases. These include: a) it continually retrieves the entire right-sided cardiac output, b) it contains a high-density capillary bed, c) it is the first capillary plexus met by cells after lymphatic drainage enters the venous system, and d) it consist of delicate membranes that may draw on oxygenated air to promote sustenance [12,13]. The high levels of vascularization and richness of oxygen in the lungs provides an environment rich in the nutrients required for neoplastic growth [14].…”

Section: Discussionmentioning

confidence: 99%

“…Common extrathoracic primary origins include the kidney (92%), skin (78%), breast (72%), thyroid (57%), pancreas (56%), prostate (50%), stomach (47%), uterus (44%), colon (41%) [16]; however, virtually any primary malignancy can metastasize to the lung [12]. In our surgical pathology review over the past 14 years, the common sites of the primary lesion included the breast (28.3%), gastrointestinal system (27.8%), kidney (8.7%), skin (7.0%), and thyroid (4.3%).…”

Section: Discussionmentioning

confidence: 99%

Uncommon Pulmonary Metastases and Metastasectomy: A Review

Kanthan¹,

Jl²,

Sc³

2012

J Cancer Sci Ther

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Background:The development of pulmonary metastases is a critical step in oncology management as it is a major determinant of survival for patients with cancer. Primaries that commonly metastasize to the lung arise from breast, head/neck, and the gastrointestinal tract. The aim of this study was to review the pathobiogenesis of pulmonary metastases and the evolution of curative pulmonary metastasectomy as reported in the literature in addition to analyzing in detail uncommon pulmonary metastatic lesions received over a period of 14 years. Design:The indexed uncommon pulmonary metastases were reviewed and analyzed in detail. A 14-year (1996-2010) computer-based review using the Laboratory-Information-System was conducted in our laboratory. Results were categorized based on age, sex, and primary sites of origin with special emphasis to study unusual pulmonary metastases.Results: 230 cases of pulmonary metastases were retrieved on review. 129 females (56%) and 101 males (44%) ranging in age from 19 months to 91 years (median 65 years) were identified with their primary sites of origin being: breast (28.3%), gastrointestinal tract (27.8%), kidney (8.7%), and melanoma (7.0%). Three uncommon diagnoses were identified and studied in detail: 1) an index case of metastatic benign pleomorphic adenoma, case series of 2) endometrial stromal sarcoma and 3) osteosarcoma. Conclusion:Due to the poor prognosis of metastatic lung cancer, early recognition with accurate diagnosis is an important step for optimal patient management. In this context, pathologic awareness of uncommon metastases remains a challenging task. Pulmonary metastasectomy is a curative option for an increasing number of patients due to recent advances in chemotherapy that achieve locoregional control of the primary tumours. With this increased number of pulmonary metastasectomy, recognition of not only 'common' pulmonary malignancies but also more rare entities becomes central to best practices in surgical pathology.

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“…As diagnostics usually have to cope with scarce tumour material, which hardly allows satisfactory differentiation of tumour entities by morphology and heterogeneity of the material is well known, development and application of specific markers are crucial. The majority of metastases within the lung are adenocarcinomas ( Dail and Hammar, 2008 ). Therefore, discrimination between primary lung adenocarcinoma and metastasis influences the subsequent therapies ( Tanaka et al , 2008 ; Zheng and Fernando, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

“…Hence, we were able to show in an extensive study that MAdL is only expressed in alveolar macrophages, AECII and proximal tubules of the kidney in non-malignant tissues. Emphasising on malignant tissues, MAdL can exclusively be found in adenocarcinomas, whereas adenoid-differentiated extrapulmonary malignancies, which usually metastasise to the lung ( Dail and Hammar, 2008 ), were not detected. Furthermore, only adenoid parts of adenosquamous carcinomas, as well as one case of chromophile renal cell carcinoma, displayed positivity for MAdL.…”

Section: Discussionmentioning

confidence: 99%

Generation and evaluation of a monoclonal antibody, designated MAdL, as a new specific marker for adenocarcinomas of the lung

et al. 2011

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Background:Different therapy regimens in non-small-cell lung cancer (NSCLC) are of rising clinical importance, and therefore a clear-cut subdifferentiation is mandatory. The common immunohistochemical markers available today are well applicable for subdifferentiation, but a fraction of indistinct cases still remains, demanding upgrades of the panel by new markers.Methods:We report here the generation and evaluation of a new monoclonal antibody carrying the MAdL designation, which was raised against primary isolated human alveolar epithelial cells type 2.Results:Upon screening, one clone (MAdL) was identified as a marker for alveolar epithelial cell type II, alveolar macrophages and adenocarcinomas of the lung. In a large-scale study, this antibody, with an optimised staining procedure for formalin-fixed tissues, was then evaluated together with the established markers thyroid transcription factor-1, surfactant protein-A, pro-surfactant protein-B and napsin A in a series of 362 lung cancer specimens. The MAdL displays a high specificity (>99%) for adenocarcinomas of the lung, together with a sensitivity of 76.5%, and is capable of delivering independent additional diagnostic information to the established markers.Conclusion:We conclude that MAdL is a new specific marker for adenocarcinomas of the lung, which helps to clarify subdifferentiation in a considerable portion of NSCLCs.

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Metastases to and from the Lung

Cited by 7 publications

References 260 publications

Papillary Carcinoma of Thyroid Metastatic to AdenocarcinomaIn Situof Lung: Report of an Unusual Case

Papillary Carcinoma of Thyroid Metastatic to AdenocarcinomaIn Situof Lung: Report of an Unusual Case

Uncommon Pulmonary Metastases and Metastasectomy: A Review

Generation and evaluation of a monoclonal antibody, designated MAdL, as a new specific marker for adenocarcinomas of the lung

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