Metastases to and from the Lung

Dail, David H.

doi:10.1007/978-1-4757-3935-0_35

Cited by 3 publications

(1 citation statement)

References 216 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, there were 165 cases of metastatic tumors, the most common metastasis to lung was from breast carcinoma (55 cases, 33.3%), followed by 34 cases (20.6%) of colorectal carcinoma and 12 cases (7.3%) of renal cell carcinoma. According to the data from International Registry Lung Metastases and another similar study of Indian population, the top three lung metastatic tumors were colorectal carcinoma (33-37%), breast carcinoma (17-19%), and renal cell carcinoma (12-17%) [9][10][11][12]. Actually, the global incidence of colorectal cancer is lower than that of breast cancer [3].…”

Section: Discussionmentioning

confidence: 99%

Analysis of lung biopsies using the 2015 WHO criteria and detection of sensitizing mutations——a single-institution experience of 5032 cases

et al. 2020

View full text Add to dashboard Cite

Background: A specialized classification for small biopsies was added to the 2015 WHO classification of lung tumors. The purpose of this study is to explore and summarize the experience of applying the newly proposed classifications and criteria to clinical practice. Methods: We used the 2015 WHO criteria to sort out 5032 small lung biopsies from a group of Chinese patients, and demonstrated their clinicopathological features, mutational status and the relationship between these factors. Results: The most common diagnosis was primary lung carcinoma (3130, 62.2%), among which adenocarcinoma (1421, 28.2%) was the most frequent histological type. The mutational assays using ARMS-PCR technology demonstrated that EGFR was positive in 56.1% cases(499/889, from adenocarcinoma and NSCC, favor adenocarcinoma), ALK in 5.7% cases(12/211, from NSCC, which comprised all the primary lung carcinomas except small cell carcinomas), and ROS1 in 0.9% cases(2/211, from NSCC). Another 898 NSCC specimens went through an immunohistochemical (IHC) examination for ALK (D5F3) and 38 of them were positive (4.2%). The overall mutation rate of ALK was 4.5% (50/1119). There was no significant difference between ARMS-PCR and immunohistochemistry in the positive rate of ALK mutation detection (P = 0.359). EGFR mutations (P = 0.02) and ALK mutations (P < 0.001) both decreased with an increasing patient age. Furthermore, the amount of EGFR mutations was higher in adenocarcinoma (64.1% vs 34.1%, P < 0.001) than in NSCC, favor adenocarcinoma. In contrast, ALK mutations were more common in NSCC, favor adenocarcinoma (4.2% vs 8.4%, P = 0.021). Conclusions: This single-center study exhibited a large subset of small lung biopsies from a Chinese institution and demonstrated that applying the 2015 WHO classification for small lung biopsies can help predict the mutational status of primary lung carcinomas.

show abstract