Metastases to and from the Lung

Dail, David H.

doi:10.1007/978-1-4612-2496-9_4

Cited by 3 publications

(4 citation statements)

References 225 publications

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“…The lung is one of the most frequent site of metastasis in the case of extrathoracic cancers. This phenomenon can be explained in terms of presence of certain features like: 1) they continuosly receive the entire right-sided cardiac output with every heartbeat; 2) they are the first capillary plexus met by cells after most of the lymphatic drainage enters the venous system; and 3) they consist of delicate membranes that may be beneficial for initially drawing on nearby oxygenated air for early sustenance 8. However, lung carcinoma is one of the rarest recipients for tumor-to-tumor metastasis.…”

Section: Discussionmentioning

confidence: 99%

Papillary Carcinoma of Thyroid Metastatic to AdenocarcinomaIn Situof Lung: Report of an Unusual Case

Kim

Chu

et al. 2012

Korean J Pathol

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The tumor-to-tumor metastasis is a rare event. The lung tumors are the most common donor tumors in tumor-to-tumor metastasis, but are exceedingly rare as a recipient. Here, we report a case of papillary thyroid carcinoma (PTC) metastasizing to adenocarcinoma in situ (AIS, formerly bronchioloalveolar carcinoma) of the lung in a 44-year-old woman who underwent total thyroidectomy for PTC 8 years ago. To the best of our knowledge, the present case is the first case reporting on PTC metastasized to AIS. A review of the relevant literature is presented.

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Section: Discussionmentioning

confidence: 99%

Papillary Carcinoma of Thyroid Metastatic to AdenocarcinomaIn Situof Lung: Report of an Unusual Case

Kim

Chu

et al. 2012

Korean J Pathol

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“…This is related to several unique features of the lungs: they receive the entire cardiac output every minute, they have the densest capillary bed in the body, they are the first capillary plexus met after most of the lymphatic drainage enters the venous system, and they consist of delicate membranes that may be beneficial for drawing on nearby oxygenated air for sustenance. 3 The most common situation is presentation in patients with known extrapulmonary solid neoplasm; in this setting metastases are correctly identified in the majority of cases without the need for invasive procedures. 4 However, especially when the primary tumor is still unidentified, or when the clinical features and laboratory findings are atypical or confusing, or the tumors are of mesenchymal origin, disseminated lung neoplasms may imitate other diffuse infiltrative lung diseases either for the clinical profile or for the radiographic findings.…”

Section: Diffuse Lung Tumors: Morphological and Imaging Correlationsmentioning

confidence: 99%

Bronchoalveolar Lavage in Malignancy

Poletti

Murer

et al. 2007

Semin Respir Crit Care Med

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Bronchoalveolar lavage is a useful diagnostic tool in diffuse or disseminated lung malignancies that do not involve the bronchial structures visible by endoscopy. The neoplastic histotype and the intraparenchymal neoplastic growth pattern are good predictors for diagnostic yield; adenocarcinoma, and tumors with lymphangitic or lepidic growth patterns more easily diagnosed by bronchoalveolar lavage; in these cases the diagnostic yield reported is higher than 80%. In hematologic malignancies the diagnostic yield is quite good in secondary diffuse indolent B cell lymphomas and in primary B cell lymphomas of mucosa-associated lymphoid tissue (MALT Q3 ) type but low in Hodgkin disease. Morphological analysis may be implemented by immunocytochemical or molecular tests to identify the cell lineage and the presence of monoclonality. Disorders in which bronchioloalveolar cell hyperplasia/dysplasia is a significant morphological component may have cytological features in bronchoalveolar lavage fluid that mimic lung neoplasms: acute respiratory distress syndrome (ARDS), acute interstitial pneumonitis (AIP), and acute exacerbation of idiopathic pulmonary fibrosis are the most important clinical entities in this group.

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“…As diagnostics usually have to cope with scarce tumour material, which hardly allows satisfactory differentiation of tumour entities by morphology and heterogeneity of the material is well known, development and application of specific markers are crucial. The majority of metastases within the lung are adenocarcinomas (Dail and Hammar, 2008). Therefore, discrimination between primary lung adenocarcinoma and metastasis influences the subsequent therapies (Tanaka et al , 2008; Zheng and Fernando, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Hence, we were able to show in an extensive study that MAdL is only expressed in alveolar macrophages, AECII and proximal tubules of the kidney in non-malignant tissues. Emphasising on malignant tissues, MAdL can exclusively be found in adenocarcinomas, whereas adenoid-differentiated extrapulmonary malignancies, which usually metastasise to the lung (Dail and Hammar, 2008), were not detected. Furthermore, only adenoid parts of adenosquamous carcinomas, as well as one case of chromophile renal cell carcinoma, displayed positivity for MAdL.…”

Section: Discussionmentioning

confidence: 99%

Generation and evaluation of a monoclonal antibody, designated MAdL, as a new specific marker for adenocarcinomas of the lung

et al. 2011

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Background:Different therapy regimens in non-small-cell lung cancer (NSCLC) are of rising clinical importance, and therefore a clear-cut subdifferentiation is mandatory. The common immunohistochemical markers available today are well applicable for subdifferentiation, but a fraction of indistinct cases still remains, demanding upgrades of the panel by new markers.Methods:We report here the generation and evaluation of a new monoclonal antibody carrying the MAdL designation, which was raised against primary isolated human alveolar epithelial cells type 2.Results:Upon screening, one clone (MAdL) was identified as a marker for alveolar epithelial cell type II, alveolar macrophages and adenocarcinomas of the lung. In a large-scale study, this antibody, with an optimised staining procedure for formalin-fixed tissues, was then evaluated together with the established markers thyroid transcription factor-1, surfactant protein-A, pro-surfactant protein-B and napsin A in a series of 362 lung cancer specimens. The MAdL displays a high specificity (>99%) for adenocarcinomas of the lung, together with a sensitivity of 76.5%, and is capable of delivering independent additional diagnostic information to the established markers.Conclusion:We conclude that MAdL is a new specific marker for adenocarcinomas of the lung, which helps to clarify subdifferentiation in a considerable portion of NSCLCs.

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Metastases to and from the Lung

Cited by 3 publications

References 225 publications

Papillary Carcinoma of Thyroid Metastatic to AdenocarcinomaIn Situof Lung: Report of an Unusual Case

Papillary Carcinoma of Thyroid Metastatic to AdenocarcinomaIn Situof Lung: Report of an Unusual Case

Bronchoalveolar Lavage in Malignancy

Generation and evaluation of a monoclonal antibody, designated MAdL, as a new specific marker for adenocarcinomas of the lung

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