Métastases mammaires de cancers d’origine extra-mammaire : état des lieux et difficultés diagnostiques

Koch, A.; Richter-Marot, A; Wissler, Marie-Pierre; Baratte, A.; Mathelin, Carole

doi:10.1016/j.gyobfe.2013.09.013

Cited by 27 publications

(35 citation statements)

References 46 publications

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“…According to a review of the literature by Koch et al . [3], malignant melanoma is the most common cancer to metastasize to the breast (29.8%). Other cancers known to metastasize to the breast are: lung cancer (16.4%), gynecological cancers with a majority of ovarian cancers (12.7%), digestive tumors (9.9%), leukemia and lymphomas (8.4%), sarcomas (7.3%), and renal tumors (1.5%).…”

Section: Discussionmentioning

confidence: 99%

Intramammary metastatic melanoma of unknown primary origin in a 58-year old patient: a case report

El-Tani

Duc

Gluecker³

et al. 2016

J Med Case Reports

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BackgroundMalignant melanoma metastasis to the breast is a rare disease.Case presentationWe present the case of a 58-year-old postmenopausal Caucasian woman with metastatic malignant melanoma of unknown origin of the right breast. She presented with a palpable lump in the inferior quadrant of her right breast. The investigations concluded it was breast metastasis from a malignant melanoma of unknown origin. The treatment consisted of mastectomy and axillary lymph node dissection. Two lymph nodes were positive for tumor cells and one showed extracapsular extension. Our patient did not receive immediate adjuvant therapy. Six weeks after the surgery, our patient presented a relapse in the right axilla (a 6 × 4 cm mass) with positive internal mammary lymph nodes and a single brain metastasis. This relapse motivated an adjuvant treatment with partial regression of the disease. Currently, our patient presents multiple metastases with poor prognosis.ConclusionsFrom this experience, we advocate an immediate aggressive handling of melanoma metastasis to the breast.

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Section: Discussionmentioning

confidence: 99%

Intramammary metastatic melanoma of unknown primary origin in a 58-year old patient: a case report

El-Tani

Duc

Gluecker³

et al. 2016

J Med Case Reports

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“…Pour notre patiente, il n'a pas é té mis en é vidence d'adé nopathies susclaviculaires, et l'atteinte des ganglions axillaires homolaté raux a probablement é té lié e à la dissé mination par voie lymphatique des cellules cancé reuses mammaires. L'atteinte ganglionnaire axillaire lors du diagnostic de mé tastases intra-mammaires (quel que soit le primitif) est d'ailleurs observé e dans un tiers des cas [1].…”

Section: Discussionunclassified

“…Elles repré sentent moins de 0,5 % de l'ensemble des cancers mammaires [1]. Les mé tastases intra-mammaires provenant de tumeurs neuro-endocrines (TNE) sont exceptionnelles et leur prise en charge thé rapeutique ne fait pas l'objet d'un consensus.…”

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Métastases intra-mammaires d’une tumeur neuro-endocrine d’origine pulmonaire : place du traitement loco-régional mammaire

Bernard

Benabu

et al. 2016

Gynécologie Obstétrique & Fertilité

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“…Breast cancer is the most common malignancy in women, whereas metastases to the breast from extramammary malignancies are very rare, accounting for only 0.43% of all malignant breast tumors [1]. The most common primary tumors metastasizing to the breast are melanoma (29.8%), lung carcinoma (16.4%), gynecological carcinoma (12.7%), intestinal carcinoma (9.9%), leukemia and lymphoma (8.4%), rhabdomyosarcoma (7.3%), and renal cell carcinoma (1.5%) [1].…”

Section: Introductionmentioning

confidence: 99%

“…The most common primary tumors metastasizing to the breast are melanoma (29.8%), lung carcinoma (16.4%), gynecological carcinoma (12.7%), intestinal carcinoma (9.9%), leukemia and lymphoma (8.4%), rhabdomyosarcoma (7.3%), and renal cell carcinoma (1.5%) [1]. The time interval between diagnosis of primary cancer and the appearance of breast metastases ranges from 1 to 5 years [2].…”

Section: Introductionmentioning

confidence: 99%

Breast cancer or metastasis? An unusual case of metastatic malignant pleural mesothelioma to the breast

Framarino-dei-Malatesta

Sammartino

Derme

et al. 2015

World J Surg Onc

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BackgroundMetastases to the breast from extramammary malignancies are very rare, and ruling out the diagnosis of primary breast tumor is important in order to decide on clinical management and predict prognosis.Case presentationClinical examination revealed in a 49-year-old hairdresser a 3-cm hard lump adherent to the underlying layers in the right breast. Trucut biopsy was performed. Histology showed a solid proliferation of medium-sized neoplastic polygonal cells. Immunohistochemical analysis showed tumor cells diffusely positive for cytokeratin 8/18 and calretinin and focally positive for cytokeratin 5/6 and Wilms’ tumor 1, e-cadherin, and human bone marrow endothelial-1. Estrogen receptors and progesterone receptors were negative. The final diagnosis was metastatic epithelioid malignant pleural mesothelioma.ConclusionsImmunohistochemistry is an important tool for a conclusive diagnosis of malignant pleural mesothelioma. Owing to the degree of histological and immunohistochemical overlap, a high level of clinical suspicion is essential in order to avoid unnecessary mutilating surgery.

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Métastases mammaires de cancers d’origine extra-mammaire : état des lieux et difficultés diagnostiques

Cited by 27 publications

References 46 publications

Intramammary metastatic melanoma of unknown primary origin in a 58-year old patient: a case report

Intramammary metastatic melanoma of unknown primary origin in a 58-year old patient: a case report

Métastases intra-mammaires d’une tumeur neuro-endocrine d’origine pulmonaire : place du traitement loco-régional mammaire

Breast cancer or metastasis? An unusual case of metastatic malignant pleural mesothelioma to the breast

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