Metastases in the sphenoidal sinus in a patient with papillary thyroid cancer

Vázquez, Sonia Argibay; Hernández, Carmen Lancha; Munñiz, Ángel Martínez

doi:10.1007/bf02710273

Cited by 15 publications

(6 citation statements)

References 15 publications

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“…Synchronous or simultaneous tumors of the head and neck and the lung are seen in 31% incidence in these cases. 7 Therefore, discrimination of second primary or metastatic tumors should be done in patients with lung malignancies before any decisions on treatment modality. Several criteria are described for determination of second primary or metastatic disease, but none of these is certain.…”

Section: Discussionmentioning

confidence: 99%

Incidentally Diagnosed Simultaneous Second Primary Tumor of the Sphenoid Sinus in a Patient With Lung Cancer

Yiğit¹,

Taşkın²,

Demir³

et al. 2009

Journal of Craniofacial Surgery

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Synchronous tumors are described as multiple primary malignancies presenting within 6 months of diagnosis of index tumors. Synchronous tumors of the lung and the head and neck region is frequently seen. However, isolated sphenoid sinus and lung cancers are not reported yet. Here, we reported an incidentally diagnosed simultaneous second primary sphenoid sinus tumor in a patient with lung cancer. Radiological evaluation results demonstrated a significant contrast-enhanced mass in the sphenoid sinus extending through the nasopharynx because of the destruction of the sphenoid sinus. The decision was made to proceed with chemotherapy and radiotherapy treatment regimens for the sphenoid sinus lesion, and right lobectomy was performed for the lung lesion. Asymptomatic simultaneous, synchronous, or metastatic tumors must always be kept in mind, and histopathologic diagnosis should be done for both tumors because presence of second tumor anywhere may change the treatment modality.

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Section: Discussionmentioning

confidence: 99%

Incidentally Diagnosed Simultaneous Second Primary Tumor of the Sphenoid Sinus in a Patient With Lung Cancer

Yiğit¹,

Taşkın²,

Demir³

et al. 2009

Journal of Craniofacial Surgery

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“…Overall survival at 10 years is 95% in patients under 40 years of age and 75% in older patients. 15 Despite the presence of distant metastases, the patients frequently survive for several years without treatment. Lung is the most common site of metastasis followed by bone.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Follicular Carcinoma of Thyroid Metastasizing to the Sphenoid Sinus

Radhakrishnan¹,

Andru²

2015

An International Journal Clinical Rhinology

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Introduction Metastatic tumors to the nose and paranasal sinuses are unusual with 167 cases published in the literature since 1951. The most common locations of the primary tumors are renal, lung, breast, testis, gastrointestinal tract and thyroid gland. There are only 26 documented cases of metastasis to the sphenoid sinus of which only six are from follicular carcinoma thyroid. Materials and methods Case reports of two patients referred to our department with ocular symptoms having a final diagnosis of follicular carcinoma thyroid with sphenoid sinus metastasis were studied and literature review done. Discussion Metastasis to the sphenoid sinus from follicular carcinoma thyroid is a rare entity and here we present two more cases of which one was an occult thyroid carcinoma. Both patients presented with ocular symptoms and the features of metastasis was the first sign of disease. Conclusion Early diagnosis of signs and symptoms relating to metastatic sphenoid disease is necessary as these are frequently the first presentation of malignancy. Even though cure of patients with sphenoid sinus metastasis has not been reported, palliation with resolution of morbidity is possible. How to cite this article Radhakrishnan SR, Andru A, Peetta-kkandy V. Follicular Carcinoma of Thyroid Metastasizing to the Sphenoid Sinus. Clin Rhinol An Int J 2015;8(2):53-57.

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“…Papillary thyroid cancer is commonly associated with lymphatic spread to regional lymph nodes. Distant metastases occur more rarely, usually involving the lungs and bone (1–7% of patients) ( 14 ), but occasionally occurs in the brain, sphenoid sinus, orbit, adrenal, kidney and ovary ( 15 – 18 ). A retrospective review of the literature revealed only two case reports of muscle metastases arising from PTC ( 11 , 12 ).…”

Section: Discussionmentioning

confidence: 99%

“…It has been hypothesized that skeletal muscle is a hostile environment for proliferating cancer cells, due to muscle motion and unadapted muscle pH ( 19 ), which may explain the lack of such cases. Synchronous lung and skeletal muscle disease from PTC is an extremely rare manifestation ( 18 ). To the best of our knowledge, only two cases have been previously reported ( Table I ).…”

Section: Discussionmentioning

confidence: 99%

Unusual synchronous skeletal muscle and lung metastasis in papillary thyroid cancer: A case report and review of the literature

Yang

Zhang

et al. 2014

Oncology Letters

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Papillary thyroid cancer (PTC) frequently metastasizes to the cervical lymph region and less often to the lung and bone. Metastasis to the skeletal muscles from PTC is extremely rare, especially concurrent lung and skeletal muscle metastases. The present study reports the case of a 31-year-old man with synchronous metastasis to the skeletal muscle and lung from PTC, six years following total thyroidectomy and consecutive 131Iodine treatments. Magnetic resonance imaging (MRI) revealed a 1.7×1.2×1.5 cm mass in the left gastrocnemius muscle, indicating a neurogenic tumor. The mass was subsequently resected and confirmed via histopathology to be metastatic PTC. We propose that, in the follow-up of patients with PTC, the measurable serum thyroglobulin level, whole body scan and other imaging modalities including MRI or positron emission tomography/computed tomography, must be closely monitored for potential distant metastases, particularly in cases of PTC with aggressive pathological behavior.

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Metastases in the sphenoidal sinus in a patient with papillary thyroid cancer

Cited by 15 publications

References 15 publications

Incidentally Diagnosed Simultaneous Second Primary Tumor of the Sphenoid Sinus in a Patient With Lung Cancer

Incidentally Diagnosed Simultaneous Second Primary Tumor of the Sphenoid Sinus in a Patient With Lung Cancer

Follicular Carcinoma of Thyroid Metastasizing to the Sphenoid Sinus

Unusual synchronous skeletal muscle and lung metastasis in papillary thyroid cancer: A case report and review of the literature

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