Metascience in Dentistry and Medicine

Chiappelli, Francesco; Tamkin, Juliette; Giordano, Grace

doi:10.1007/978-3-031-10646-0_1

Cited by 2 publications

(4 citation statements)

References 25 publications

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“…EBHC is a product of metascience, the hypothesis-driven process of systematic inquiry of the best available evidence, and its optimal application in practice [33,34]…”

Section: Evidence-based Healthcare (Ebhc)mentioning

confidence: 99%

“…The best available evidence is derived systematically from the stringent, hypothesis-driven process of research synthesis, and is reported as systematic reviews [33][34][35][36][37][38][39][40][41][42]. Across any field of inquiry, research evidence usually results from excellent science, but it may also emerge from scientific reports that suffer from serious methodologically flaws and biases.…”

Section: Evidence-based Researchmentioning

confidence: 99%

“…Research synthesis systematically sifts out the scientific evidence that is corrupt and that should not be utilized in evidence-based practice. It pulls together the consistent and coherent high-quality science; and it generates a qualitative and quantitative (i.e., meta-analysis) consensus of the best evidence for translation and integration into new and improved evidence-based practice [1][2][3][33][34][35][36][37][38][39][40][41][42][43][44][45]. In brief, EBHC in general, and evidence-based research in particular is effectiveness-focused because risk(cost)/benefit concerns must always remain primary.…”

Section: Evidence-based Researchmentioning

confidence: 99%

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The author's state that they adhere with COPE guidelines on publishing ethics as described elsewhere at https://publicationethics.org/. The authors also undertake that they are not associated with any other third party (governmental or non-governmental agencies) linking with any form of unethical issues connecting to this publication. The authors also declare that they are not withholding any information that is misleading to the publisher in regard to this article.

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“…EBHC is a product of metascience, the hypothesis-driven process of systematic inquiry of the best available evidence, and its optimal application in practice [33,34]…”

Section: Evidence-based Healthcare (Ebhc)mentioning

confidence: 99%

Section: Evidence-based Researchmentioning

confidence: 99%

Section: Evidence-based Researchmentioning

confidence: 99%

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2023

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“…EBHC is a product of metascience, the hypothesis-driven process of systematic inquiry of the best available evidence, and its optimal application in practice [ 33 , 34 ]. It integrates the best available evidence obtained by the systematic synthesis of evidence-based research into evidence-based practice.…”

Section: Evidence-based Healthcare (Ebhc)mentioning

confidence: 99%

Evidence-based modalities in the management of Psoriasis and Psoriatic arthritis

Chiappelli

2023

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Psoriasis is a waxing and waning skin disorder, often associated with a plethora of co-morbidities, including psoriatic arthritis (PsA), a severe form of chronic inflammatory arthritis. All forms of psoriasis and PsA are immune-mediated diseases where the patient's immune system is overactive in the production of certain factors that stimulate and activate the function of certain immune cells. Recent evidence has uncovered an important role for cell-mediated immunity in the aetiology and course of psoriasis and PsA, with a critical role played by the pro-inflammatory IL-23/TH17 axis. Taken together, these new lines of evidence suggest new and improved therapeutic interventions for patients with psoriasis and PsA. The hypothesis-driven process of inquiry of the best available evidence and its implication, application and evaluation in the context of clinical practice pertains to the meta-science of evidence-based health care (EBHC). EBHC consists in the initial step of research synthesis and generation of the systematic review of the best available evidence, estimated both qualitatively and quantitatively (i.e., meta-analysis). Evidence-based decision-making, a process driven and controlled by the expertise of the clinician and by the clinical needs and personal wants of the patient, is the principal, most timely and critical aspect of evidence-based practice. Recent and systematic reviews for the treatment of psoriasis and PsA consistently updated for emerging new and revised data (i.e., living systematic reviews) confirm the efficacy and the effectiveness of methotrexate (MTX) in containing and controlling psoriasis. The outcomes of MTX intervention for PsA remain mixed and inconclusive.

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Metascience in Dentistry and Medicine

Cited by 2 publications

References 25 publications

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Evidence-based modalities in the management of Psoriasis and Psoriatic arthritis

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