Metaplastic Ossification in a Juvenile Rectal Polyp: A Rare Histological Finding

Garg, Monika; Kaur, Jasveen; Bindroo, Samridhi; Sharma, Anuradha; Mahajan, Nanak Chand

doi:10.7860/jcdr/2013/5403.2972

Cited by 10 publications

(13 citation statements)

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“…The polyp size varied from 5mm to 20mm, with a mean size of 13.3mm and majority being located in the rectum (87.5%) [ Table 1]. Juvenile polyps are hamartomatous lesions which may show the phenomenon of osseous metaplasia [3]. Mark (1964) first described bone formation within juvenile rectal polyp [4].…”

Section: Discussionmentioning

confidence: 99%

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Juvenile rectal polyp with osseous metaplasia- A rare case report.

Nandyal¹,

K²,

Manjunath³

2017

Am J Res Med Sci

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Section: Discussionmentioning

confidence: 99%

“…There are only few case reports of neoplastic and non neoplastic gastrointestinal polyps with osseous metaplasia [2,3]. An electronic literature search undertaken revealed only eight cases of juvenile colonic polyps with osseous metaplasia and fourteen cases of other morphological types of colorectal polyps with bone formation [4,5].…”

Section: Introductionmentioning

confidence: 99%

Juvenile rectal polyp with osseous metaplasia- A rare case report.

Nandyal¹,

K²,

Manjunath³

2017

Am J Res Med Sci

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“…The most of previous reports are associated with mucin-producing colonic adenocarcinomas [1]. Only a few of reported cases have been documented that osseous metaplasia can occur in a variety of benign conditions, such as colorectal polyps and lesions associated with inflammation and ulceration [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Despite of distinctive morphology, the underlying pathogenesis of osseous metaplasia in gastrointestinal tract has not yet been elucidated.…”

Section: Introductionmentioning

confidence: 99%

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2017

JCRC

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Background:Osseous metaplasia occurring within the gastrointestinal tract is a rare phenomenon. Only a few of cases have been documented that osseous metaplasia can occur in colorectal polyps, although its underlying pathogenesis has not yet been elucidated. Methods: Two cases of osseous metaplasia within inflammatory and adenomatous polyps of colon, respectively.The clinical and histological features of this lesion, as well as suggested mechanisms for its pathogenesis are discussed.Results: Under the histological examination, both cases demonstrate the typical normal-looking osseous trabeculae rimmed by a layer of scattered osteoblasts in the stroma of inflammatory polyp or tubular adenoma of colon. To the best of our knowledge, they are possible the first cases of osseous metaplasia in colorectal polyps in Chinese. Conclusion:Although it has not been found to have any significance in clinical treatment and prognostic evaluation, our data suggest that persistent inflammatory process and/or pluripotent stromal cells in polyps might contribute to the formation of osseous metaplasia in colonrectal neoplastic and non-neoplastic polyps.

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“…Osseous metaplasia is a heterotopic bone formation 1 . While it is rarely seen in various types of polyps of the stomach, colon, and rectum of the gastrointestinal tract, its occurrence in colonic polyps is extremely rare [2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

“…Mark, in 1964, firstly descripted bone formation within a rectal polyp 4 . The mechanism of this metaplastic change has not been completely understood [1][2][3] . Clinically and prognostically, its significance is not known 1 .…”

Section: Introductionmentioning

confidence: 99%