Metaplastic Carcinoma with Foci of Chondrosarcoma in Breast: A Rare Case

Vias, Poorva; Pandey, Awadhesh Kumar; Dimri, Kislay; Bhagat, Ranjeev

doi:10.31557/apjcc.2019.4.4.131-133

Cited by 1 publication

(2 citation statements)

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“…This study presents clinical features, outcomes, and prognostic factors of forty patients of MBC, managed at our tertiary care institute. Generally, MBC presents with bigger size, higher grade and stage, triple negative hormone receptors with less metastasis to the lymph nodes and more possibility of distant metastasis when compared with Invasive Ductal Carcinoma (IDC) (Lai et al,2013;Vias et al,2019). Patients with MBC usually present at a median age of around 60 years (Rayson et al, 1999) while earlier diagnosis at the mean age of 50 years is also reported (Pitts et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological and Radiological Features with Long Term Follow Up of Metaplastic Carcinoma Breast in India

Puri

Khadka

Kataria

et al. 2021

Asian Pac J Cancer Prev

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Objective: Metaplastic breast carcinoma (MBC) is a heterogeneous group of invasive carcinomas with squamous and/or mesenchymal differentiation. Because of their rare occurrence, the information regarding the clinical behaviour of metaplastic carcinomas is limited. The purpose of our study was to delineate the clinicopathological and radiological features, treatment outcomes, prognostic factors, and survival of patients with MBC. Methods: Ambispective observational study with prospective recruitment was done from 1 st January 2019 to 31 st August 2020. Retrospective data included between 1 st January 2009 and 31 st December 2018. In the retrospective group surgical database of our department was searched and those with MBC diagnosis on post-operative histopathology recruited. In prospective group patients with MBC on core biopsy were followed and those operated were included. The patients followed up at our breast cancer clinic (BCC) and their demographic, clinical, pathological radiological and treatment details noted. Results: Forty patients formed the study population. The mean age of the patents was 42 years. Ipsilateral axillary lymph node metastasis was present in 22.5%. The pathological median tumor size was 5.4 (range 2.1 to 22 cm). The most common differentiation was cartilaginous (35%) followed by squamous (32.5%). The most common mammographic grading was BIRADS 4 (Breast Imaging Reporting and Data system). Magnetic resonance imaging was T2 hyperintense with peripheral rim enhancement and restriction on DWI. The median overall (OS) and disease-free survival (DFS) was 42 and 40 months, respectively. Fifteen patients (37.5%) had disease related mortality. A subgroup analysis revealed that, type of differentiation, histopathology and tumor size > 5cm affected both OS and DFS significantly. Conclusion: Metaplastic breast cancer in our setup presents in young patients with aggressive large tumors at a higher stage and diverse histopathology and with comparable overall and disease-free survival. The histological subtype, tumor differentiation and tumor size are prognostic factors.

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Section: Discussionmentioning

confidence: 99%

“…These are usually CD 34 negative as it is positive in phyllodes, and sarcoma of the breast. Although mixed tumors are rare, there are case reports of MBC with cartilaginous differentiation with a co-existing foci chondrosarcoma with lympho-vascular invasion (Vias et al,2019).…”

Section: Discussionmentioning

confidence: 99%