Metaplastic carcinoma breast (carcinosarcoma variant)

Pai, B. Srinivas; Agarwal, Saurabh; Srinivasan, G.; Rao, Lakshmi; Rao, Anjali

doi:10.1007/s12262-010-0104-6

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…Although knowledge is still vague for MBC, data are available concerning the clinical and immunohistochemical factors that have been shown to affect the prognosis of patients with MBC. Tumor size, ratio of differentiation, and high histologic grade are prognosis-related factors [27]. Recurrence rate of MBC is high.…”

Section: Discussionmentioning

confidence: 99%

Metaplastic Breast Carcinoma: Analysis of 44 Cases

et al. 2020

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In the present research, a full series of 44 cases investigating metaplastic breast carcinoma (MBC) have been presented to clarify uncertainty in variables for diagnosis, categorization, and treatment strategies. Forty-four MBC female patients have been treated between Jan 2009 and Dec 2019 were retrospectively investigated and presented in this research. Demographic characteristics of the patients, types of surgery, tumor sizes, axillary involvement, tumor stages, and planned adjuvant treatments were considered and evaluated using the database of the hospital. Tumor diameter was less than 20 mm in 8 cases (18.8%), in between 20 and 50 mm in 23 cases (52.2%), and greater than 50 mm in 13 cases (29.5%). Both estrogen and progesterone receptors were found negative in 38 cases, and positive in 6 cases. The mean Ki-67 expression was determined as 51.36 ± 31.20 (range, 2 to 90) in 44 cases (100%). The mean follow-up period was 59.8 ± 39.4 (range, 10 to 120) months. All cases were alive during the follow-up. In the present research, an investigation with one of the largest single-institution data with the patients with MBC is presented. It is also critical that MBC has been associated with a poor prognosis, despite the low nodal involvement. Most patients in the series had negative axillary lymph node involvement, large tumor diameter, and hormone receptor negativity. Therefore, the present research is valuable in the literature and beneficial for researchers and readers.

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Section: Discussionmentioning

confidence: 99%

Metaplastic Breast Carcinoma: Analysis of 44 Cases

et al. 2020

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“…Similarly in our patient, the hormone receptors and c-erb B2 were negative. Tumor size, differentiation rate, and high histologic grade are associated with prognosis (12). Presence of distant metastases is an important factor determining survival (1).…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the Breast: Case Report

et al. 2014

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Carcinosarcoma of the breast represents less than 1% of primary breast mailgnancies. Both malign epithelial and malign mesenchymal elements exist together in the breast. A 59 year old postmenopausal women presents with a bloody nipple discharge and mass in breast. In left breast 2x1 cm mss detected and excisied. At pathological examination breast carcinosarcoma was detec-ted. Then modified radical mastectomy was performed. Tumor measured 4x4x3.5 cm. Tumor cells were negative for estrogen, progesteron. C-erb-B2 was negative. There was no metastasis in axillary lymph node metastasis. Carcinosarcoma of breast is rare tumor. It mass be consider in diagnosis of patients with large breast mass.Key words: Breast cancer, carcinosarcoma, metaplastic cancer IntroductionCarcinosarcoma of the breast is an aggressive tumor constituting less than 1% of all breast cancers (1). It contains a combination of malignant epithelial and malignant mesenchymal cells (2). In this case report, findings of a patient who had been operated with a diagnosis of breast carcinosarcoma and the relevant literature data are presented. Case PresentationA 59-year-old female patient presented with bloody nipple discharge and a lump in her left breast for the last 2 months. On physical examination, a 4x4 cm mass was observed at the 1-2 o'clock position in the left breast. The ultrasonographic examination showed a regular bordered, hypoechoic solid lesion that contains calcifications, and in 40 mm diameter at the 12 o'clock position in the left breast. Distortion was observed in the breast parenchyma surrounding the lesion. Mammographic examination revealed a nodular opacity of 3.5 cm in size in the outer quadrant of the left breast that contains microcalcifications and distortion of the surrounding tissues.An excisional biopsy was performed in another center and the histopathological examination was compatible with carcinosarcoma, thus the patient was referred to our clinic. An informed consent was obtained and surgery was recommended. The patient underwent modified radical mastectomy.The histopathological examination of the mastectomy specimen identified the tumor size as 4x4x3,5 cm. The tumor contained 5-10% of ductal carcinoma in situ foci, with areas of microcalcifications, tumor necrosis was observed in 50% -60 of the tumor, there was no lymphovascular invasion, but perineural invasion was frequently seen. Immunohistochemical examination showed the tumor as epithelial membrane antigen (+), Vimentin (+), high molecular weight cytokeratin (-), CK 7 and smooth muscle actin (+), and non-specific staining with S 100 (Figure 1, 2). The estrogen receptor (ER) and progesterone receptor (PR) were negative. C-erbB 2 was negative. Metastasis was not observed in any of the 20 removed axillary lymph nodes. Discussion and ConclusionsCarcinosarcoma of the breast is a malignant sarcomatoid metaplasia of epithelial carcinoma. It is included in the group of metaplastic breast tumors. Malignant epithelial and malignant mesenchymal cells are found together. ...

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“…The histological origin of breast carcinosarcoma remains unclear, but it may be derived from stem cells with biphasic differentiation, from metaplasia of myoepithelial cells and myofibroblasts, or from preexisting fibroadenomas and phyllodes (3,14). Most evidence suggests that tumors are of myoepithelial origin with both carcinomatous and sarcomatous characteristics on histopathology (7,11,13). The epithelial component of breast carcinosarcoma may contain undifferentiated adenocarcinoma, infiltrating ductal carcinoma, in-situ carcinoma, or squamous cell carcinoma.…”

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confidence: 99%

“…Radiation therapy is recommended for patients with ≥ 4 axillary lymph node metastases, with a tumor size of ≥ 5 cm and in the presence of chest wall invasion, which may prevent local recurrence (8,12,14,16). Gefitinib and cetuximab, as therapeutic agents targeting EGFR/HER-1, are potent as novel treatment regimens (1,3,9,13,14). Most breast carcinosarcoma cases are not sensitive to neoadjuvant chemotherapy.…”

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confidence: 99%

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

Guo

Sun

Zhang

et al. 2019

Iran Red Crescent Med J

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Introduction: Breast carcinosarcoma is an extremely rare breast tumor comprising two distinct components, a carcinomatous component and a non-epithelial component of mesenchymal origin. It is a subtype of metaplastic carcinoma with a difficult preoperative diagnosis. Case Presentation: We present the case of a 68-year-old postmenopausal woman with squamous metaplasia coexisting with adenocarcinoma in the epithelial component of a breast carcinosarcoma. She has been admitted in

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Metaplastic carcinoma breast (carcinosarcoma variant)

Cited by 3 publications

References 3 publications

Metaplastic Breast Carcinoma: Analysis of 44 Cases

Metaplastic Breast Carcinoma: Analysis of 44 Cases

Carcinosarcoma of the Breast: Case Report

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

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