Metaplastic breast cancer with chondroid differentiation—case report and literature review

Leite, Cláudia da Costa; Dias, Nuno; Oliveira, Domingos Sávio Ferreira de; Pinto, Rui; Vaz, Francisco Cortez

doi:10.1093/jscr/rjab113

Cited by 3 publications

(5 citation statements)

References 7 publications

(6 reference statements)

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“…2 In our case, the primary tumor was a rare MpBC with chondroid differentiation. This particular histological subtype of breast carcinoma is rare, 28 and, as far as we know, has never been reported to spread to any salivary gland. The high incidence of distant metastases and low nodal involvement rates suggests that the hematogenous route plays an essential role in its dissemination.…”

Section: Discussionmentioning

confidence: 81%

Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report

Almeida¹,

Salgado²,

Ferraz³

et al. 2023

j.rpemd

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Metastatic spread to the salivary glands is rare, occurring primarily from head and neck tumors to the parotid gland. So far, only one sublingual gland metastasis has been reported in the literature. We herein report the second case of metastasis to this gland occurring in a woman in her 50s, previously diagnosed with HER2-positive metaplastic breast carcinoma (MpBC) with chondroid differentiation, with lymph node and diffuse organ metastases. The sublingual lesion presented as a tumefaction on the floor of the mouth, causing masticatory discomfort. Histologically it was formed by epithelial cells with high-grade cytomorphological features with a large central area of chondroid differentiation. The case was clinically and pathologically challenging, given the rarity of the primary MpBC and the improbable secondary location. Alternative primary salivary gland tumors with chondroid differentiation were considered, but ultimately the clinical integration was crucial in establishing the diagnosis of MpBC metastasis to the sublingual gland.

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Section: Discussionmentioning

confidence: 81%

Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report

Almeida¹,

Salgado²,

Ferraz³

et al. 2023

j.rpemd

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“…Therefore, these 77 articles were excluded. Overall, 65 studies [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ...…”

Section: Resultsmentioning

confidence: 99%

“…It is of interest that several genetic factors and pathways have been recently related to MpBC development. Molecular pathways including overexpression of CD44 (+) and yes-associated protein, which is associated with epithelial-to-mesenchymal transition, seem to play an important part in metaplastic breast carcinogenesis [ 15 , 23 , 41 ]. However, the expression of molecular markers related to carcinogenesis seems to depend on the histological subtype.…”

Section: Discussionmentioning

confidence: 99%

“…Activating mutations of the phosphoinositide 3-kinase (PI3K) pathway and loss of the PTEN antagonist alter the microenvironment of the tumor and have been associated with resistance to therapy [ 38 ]. Furthermore, activation of the Wnt/β-catenin signaling pathway, which has been associated with dysregulated immune responses and cell cycle disruption, has been observed in MpBC cases [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

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Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

et al. 2023

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Metaplastic carcinoma of the breast (MpBC) is a very rare and aggressive type of breast cancer. Data focusing on MpBC are limited. The aim of this study was to describe the clinicopathological features of MpBC and evaluate the prognosis of patients with MpBC. Eligible articles about MpBC were identified by searching CASES SERIES gov and the MEDLINE bibliographic database for the period of 1 January 2010 to 1 June 2021 with the keywords metaplastic breast cancer, mammary gland cancer, neoplasm, tumor, and metaplastic carcinoma. In this study, we also report 46 cases of MpBC stemming from our hospital. Survival rates, clinical behavior, and pathological characteristics were analyzed. Data from 205 patients were included for analysis. The mean age at diagnosis was 55 (14.7) years. The TNM stage at diagnosis was mostly stage II (58.5%) and most tumors were triple negative. The median overall survival was 66 (12–118) months, and the median disease-free survival was 56.8 (11–102) months. Multivariate Cox regression analysis revealed that surgical treatment was associated with decreased risk of death (hazard ratio 0.11, 95% confidence interval 0.02–0.54, p = 0.01) while advanced TNM stage was associated with increased risk of death (hazard ratio 1.5, 95% confidence interval 1.04–2.28, p = 0.03). Our results revealed that surgical treatment and TNM stage were the only independent risk factors related to patients’ overall survival.

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“…Metaplastic breast carcinoma (MBC) is a rare type of breast cancer with a highly aggressive nature and is associated with high mortality and morbidity [ 1 ]. It constitutes 1% of all invasive breast cancers [ 2 ]. MBCs are heterogeneous neoplasms that display a unique morphological presentation with epithelial and mesenchymal components.…”

Section: Introductionmentioning

confidence: 99%

Significance of Estrogen/Progesterone Receptor Expression in Metaplastic Breast Carcinoma

Hashmi,

Mallick,

Rashid

et al. 2024

Disease Markers

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Introduction. Metaplastic breast carcinoma (MBC) is a rare subgroup of breast neoplasms associated with adverse outcomes because of its aggressive nature. Typically, MBCs show triple-negative hormone receptor (HR) status. Determining the HR status of breast cancer is an integral part because it is an important prognostic factor and helps in the treatment course of the disease. This study aimed to determine the HR status of MBC, its significance, and its association with various clinicopathological parameters. Methods. This was a retrospective study conducted at the Department of Histopathology, Liaquat National Hospital. A total of 140 biopsy-proven cases of MBC were enrolled in the study. Clinical and pathological data were retrieved from the institutes’ archives. Immunohistochemical studies were conducted to determine the estrogen receptor (ER) and progesterone receptor (PR) status. Results. The mean age of MBC in our population was found to be 52.18 ± 12.19 years. The HR positivity rate in our population was found to be 32.9%. A significant association was found between HR status and tumor laterality, tumor size, tumor grade, tumor stage, and recurrence. ER/PR-negative MBCs were most probably associated with higher grade and higher tumor stage and were larger in size (6.62 ± 3.43 cm) than ER/PR-positive MBCs (4.20 ± 1.88 cm). Moreover, ER/PR-positive MBCs showed a higher recurrence rate than ER/PR-negative MBCs (43.5% vs. 25.5%, respectively). No statistically significant relationship was found between HR status and patient age, histological subtype, or survival rate. Conclusion. MBC is a rare breast neoplasm. MBC was found to be triple negative in most cases, but a significant percentage were HR (ER/PR) positive. Moreover, we found an association between HR status and various clinicopathological features, indicating that HR status is a significant predictor of MBC prognosis.

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Metaplastic breast cancer with chondroid differentiation—case report and literature review

Cited by 3 publications

References 7 publications

Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report

Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report

Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

Significance of Estrogen/Progesterone Receptor Expression in Metaplastic Breast Carcinoma

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