Metaplastic Breast Cancer: an Old Histotype but a Current Therapeutic Problem

Gadaleta-Caldarola, Gennaro; Nenna, Rosanna; Lanotte, Laura; Doronzo, Antonio; Gadaleta-Caldarola, Arianna; Roma, I. De; Lombardi, Lucia; Infusino, Stefania

doi:10.2217/fon-2020-0490

Cited by 4 publications

(3 citation statements)

References 59 publications

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“…In this study, the type of surgery had nothing to do with the prognosis of MBC patients, which is consistent with previously reported results ( Corso et al, 2021 ). However, different studies suggest that surgical removal of the tumor has a great benefit if combined with radiation therapy, and an improvement of overall survival has been observed for both mastectomy and lumpectomy patients ( Gadaleta-Caldarola et al, 2021 ). Li et al showed that even elderly women (≥60 years old) can benefit from radiotherapy ( Li et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Establishment of prognostic model for postoperative patients with metaplastic breast cancer: Based on a retrospective large data analysis and Chinese multicenter study

et al. 2022

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Purpose: Models for predicting postoperative overall survival of patients with metaplastic breast cancer have not yet been discovered. The purpose of this study is to establish a model for predicting postoperative overall survival of metaplastic breast cancer patients.Methods: Patients in the Surveillance, Epidemiology, and End Results database diagnosed with MBC from 2010 to 2015 were selected and randomized into a SEER training cohort and an internal validation cohort. We identified independent prognostic factors after MBC surgery based on multivariate Cox regression analysis to construct nomograms. The discriminative and predictive power of the nomogram was assessed using Harrell’s consistency index (C-index) and calibration plots. The decision curve analysis (DCA) was used to evaluate the clinical usefulness of the model. We verify the performance of the prediction model with a Chinese multi-center data set.Results: Multifactorial analysis showed that age at diagnosis, T stage, N stage, M stage, tumor size, radiotherapy, and chemotherapy were important prognostic factors affecting OS. The C-index of nomogram was higher than the eighth edition of the AJCC TNM grading system in the SEER training set and validation set. The calibration chart showed that the survival rate predicted by the nomogram is close to the actual survival rate. It has also been verified in the SEER internal verification set and the Chinese multi-center data set.Conclusion: The prognostic model can accurately predict the post-surgical OS rate of patients with MBC and can provide a reference for doctors and patients to establish treatment plans.

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Section: Discussionmentioning

confidence: 99%

Establishment of prognostic model for postoperative patients with metaplastic breast cancer: Based on a retrospective large data analysis and Chinese multicenter study

et al. 2022

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“…Nevertheless, other therapeutic options with well-studied and established targets should be considered, such as, for example, platinum based treatment, immunotherapy, and chemotherapy in MpBC [75] [107,108]. Gadaleta-Caldarola et al suggested the use of liquid biopsy as a useful tool to predict prognosis, to evaluate the effectiveness of targeted therapy and even the detection of the development of resistance [109].…”

Section: Treatment and Prognosismentioning

confidence: 99%

Translational Aspects in Metaplastic Breast Carcinoma

Barrientos-Toro,

Ding,

Raso

2024

Cancers

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Breast cancer is the most common cancer among women. Metaplastic breast carcinoma (MpBC) is a rare, heterogeneous group of invasive breast carcinomas, which are classified as predominantly triple-negative breast carcinomas (TNBCs; HR-negative/HER2-negative). Histologically, MpBC is classified into six subtypes. Two of these are considered low-grade and the others are high-grade. MpBCs seem to be more aggressive, less responsive to neoadjuvant chemotherapy, and have higher rates of chemoresistance than other TNBCs. MpBCs have a lower survival rate than expected for TNBCs. MpBC treatment represents a challenge, leading to a thorough exploration of the tumor immune microenvironment, which has recently opened the possibility of new therapeutic strategies. The epithelial–mesenchymal transition in MpBC is characterized by the loss of intercellular adhesion, downregulation of epithelial markers, underexpression of genes with biological epithelial functions, upregulation of mesenchymal markers, overexpression of genes with biological mesenchymal functions, acquisition of fibroblast-like (spindle) morphology, cytoskeleton reorganization, increased motility, invasiveness, and metastatic capabilities. This article reviews and summarizes the current knowledge and translational aspects of MpBC.

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“…Now recently conducted studies have shown that long term outcomes improved with neo-adjuvant chemotherapy and combined chemotherapy and radiotherapy (Li et al, 2019;Wang et al, 2019). The immunological studies have demonstrated a potential role of immunotherapy as it has high levels of PD-L1 and tumor infilterating T lymphocytes (Gadaleta-Caldarola et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological and Radiological Features with Long Term Follow Up of Metaplastic Carcinoma Breast in India

Puri

Khadka

Kataria

et al. 2021

Asian Pac J Cancer Prev

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Objective: Metaplastic breast carcinoma (MBC) is a heterogeneous group of invasive carcinomas with squamous and/or mesenchymal differentiation. Because of their rare occurrence, the information regarding the clinical behaviour of metaplastic carcinomas is limited. The purpose of our study was to delineate the clinicopathological and radiological features, treatment outcomes, prognostic factors, and survival of patients with MBC. Methods: Ambispective observational study with prospective recruitment was done from 1 st January 2019 to 31 st August 2020. Retrospective data included between 1 st January 2009 and 31 st December 2018. In the retrospective group surgical database of our department was searched and those with MBC diagnosis on post-operative histopathology recruited. In prospective group patients with MBC on core biopsy were followed and those operated were included. The patients followed up at our breast cancer clinic (BCC) and their demographic, clinical, pathological radiological and treatment details noted. Results: Forty patients formed the study population. The mean age of the patents was 42 years. Ipsilateral axillary lymph node metastasis was present in 22.5%. The pathological median tumor size was 5.4 (range 2.1 to 22 cm). The most common differentiation was cartilaginous (35%) followed by squamous (32.5%). The most common mammographic grading was BIRADS 4 (Breast Imaging Reporting and Data system). Magnetic resonance imaging was T2 hyperintense with peripheral rim enhancement and restriction on DWI. The median overall (OS) and disease-free survival (DFS) was 42 and 40 months, respectively. Fifteen patients (37.5%) had disease related mortality. A subgroup analysis revealed that, type of differentiation, histopathology and tumor size > 5cm affected both OS and DFS significantly. Conclusion: Metaplastic breast cancer in our setup presents in young patients with aggressive large tumors at a higher stage and diverse histopathology and with comparable overall and disease-free survival. The histological subtype, tumor differentiation and tumor size are prognostic factors.

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Metaplastic Breast Cancer: an Old Histotype but a Current Therapeutic Problem

Cited by 4 publications

References 59 publications

Establishment of prognostic model for postoperative patients with metaplastic breast cancer: Based on a retrospective large data analysis and Chinese multicenter study

Establishment of prognostic model for postoperative patients with metaplastic breast cancer: Based on a retrospective large data analysis and Chinese multicenter study

Translational Aspects in Metaplastic Breast Carcinoma

Clinicopathological and Radiological Features with Long Term Follow Up of Metaplastic Carcinoma Breast in India

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