Metaoptronic Multiplexed Interface for Probing Bioentity Behaviors

Abstract

Biointerface sensors have brought about remarkable advances in modern biomedicine. To accurately monitor bioentity’s behaviors, biointerface sensors need to capture three main types of information, which are the electric, spectroscopic, and morphologic signals. Simultaneously obtaining these three types of information is of critical importance in the development of future biosensor, which is still not possible in the existing biosensors. Herein, by synergizing metamaterials, optical, and electronic sensing designs, we proposed the metaoptronic multiplexed interface (MMI) and built a MMI biosensor which can collectively record electric, spectroscopic, and morphologic information on bioentities. The MMI biosensor enables the real-time triple-monitoring of cellular dynamics and opens up the possibility for powerlessly monitoring ocular dryness. Our findings not only demonstrate an advanced multiplexed biointerface sensor with integrated capacities but also help to identify a uniquely significant arena for the nanomaterials, meta-optics, and nanotechnologies to play their roles in a complementary manner.

Far-infrared transparent conductors

“…As an important part of the optical fiber communication system, the photodetector is a component that converts optical signals into electrical signals. It is widely applied in optical communication 12 , laser guidance 19 , biosensing 20 , etc. If the transparent electrode is replaced from the traditional ITO to our FIRTC, the applicable band of the photodetector can be complemented to far-infrared region, which will promote the development of far-infrared search and guidance technology.…”

“…Although TC in the visible, near-infrared, and mid-infrared bands have been developed, TC in the far-infrared band have not been designed. This greatly limits the development of far-infrared electromagnetic shielding 13 , 14 , infrared thermal camouflage 15 , photo detection 16 – 19 , biosensing 20 technologies, and other fields. Therefore, we focus on far-infrared transparent conductors.…”

Initiatorless Solar Photopolymerization of Versatile and Sustainable Eutectogels as Multi‐Response and Self‐Powered Sensors for Human–Computer Interface

“…[10] Flexible sensors can detect and measure various biological signals relying on excellent stretchability, reliable signal stability, and high sensing sensitivity. [11] In particular, flexible sensors can imitate the features and functions of skin tissue to monitor various mechanical deformation, like pressure [12] and strain, [13] and environmental stimuli, including humidity [14] and temperature, [15] which allow to realtime transform these stimuli into the visualized electronic signals. [16] Despite these advancements, most flexible sensors with non-integrated features can only detect either mechanical deformation or environmental stimuli due to incompatible sensing mechanisms.…”

Ultrasensitive Refractive Index Sensing Based on Hybrid High-Q Metasurfaces

“…Due to the capabilities of user-friendly operation, multifunctionality, and real-time monitoring, biosensors have brought about remarkable advances for early diagnosis, smart medicine, and healthcare monitoring. − In particular, optical biosensors are famous for high sensitivity, being contact-free, high spatial resolution, etc., and they have shown extensive research emphasis, leading to a large variety of important applications, such as point-of-care diagnostics, mid-infrared molecular fingerprints detection, and field-deployable sensors. − During the past few decades, the optical biosensors based on refractive index (RI) sensing have been cultivated as an important species with a promising future. − Such sensors are usually built by a photonic material that can sustain resonant modes under light excitation, i.e., providing peaks or valleys in absorption, reflection, or transmission spectra. Since the analytes can cause a certain variant of environment RI surrounding the sensing material, the biosensor can detect the existence and amount of analytes by monitoring the spectral shifting induced by the environment RI change.…”