Metanephric adenoma: molecular study and review of the literature

Rodríguez-Zarco, Enrique; Machuca-Aguado, Jesús; Macías-García, Laura; Vallejo-Benítez, Ana; Ríos‐Martín, J.J.

doi:10.18632/oncotarget.28192

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…2 . Differential diagnosis includes Wilms’ tumor, renal papillary neoplasms and nephrogenic rests [ 5 ]. MA can be diagnosed using hematoxylin and eosin (H&E) staining, but immunohistochemistry is needed especially when samples are obtained by core needle.…”

Section: Discussionmentioning

confidence: 99%

A giant metanephric adenoma in a young male

Mremi

Bodganowics

Sadiq

et al. 2023

Journal of Surgical Case Reports

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Metanephric adenoma is an uncommon renal tumor with almost exclusively benign behavior, which can clinically and radiologically imitate malignancy. The histological examination is therefore crucial in diagnosis. Herein, we report a case of an 18-year-old male with a huge left renal mass. Histopathology and immunohistochemistry of nephrectomy resection specimen confirmed it to be metanephric adenoma. We present our experience with this rare tumor entity and literature review with focusing on differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

A giant metanephric adenoma in a young male

Mremi

Bodganowics

Sadiq

et al. 2023

Journal of Surgical Case Reports

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Metanephric adenoma of the kidney: clinical case and literature review

Grebenkin,

Pshikhachev,

Osmolovskiy

et al. 2023

Onkourologiâ

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Metanephric adenoma is a rare benign kidney tumor with a favorable prognosis. These neoplasms are often interpreted as malignant at the preoperative stage, since they do not have specific characteristics showing during instrumental imaging methods, which leads to excessive surgical treatment in the context of nephrectomy volume. Therefore, histological verification is the gold standard for diagnosis. The morphological features of metanephric adenoma are in many ways similar to such kidney tumors as papillary renal cell carcinoma and nephroblastoma (Wilms’ tumor), so sometimes additional research methods are required, including immunohistochemical and molecular genetic ones. In this article, we report a rare clinical case of metanephric adenoma in a forty-seven-year-old woman. The results of clinical and instrumental exams, as well as morphological features of the tumor are presented. A review of the literature on the clinical, morphological, and molecular aspects of this tumor is also presented.

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Atypical metanephric adenoma: Shares similar histopathological features and molecular changes of metanephric adenoma and epithelial-predominant Wilms’ tumor

et al. 2022

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BackgroundMetanephric adenomas (MAs) are rare, benign renal tumors. Wilms’ tumors (WTs) are malignant embryonic tumors that originated from nephrogenic blastemal cells. However, some tumors have similar morphology to both MA and epithelial-predominant WT, which makes differential diagnosis difficult. We aimed to analyze the morphological, immunophenotypic and molecular changes in overlapping cases to explore their attribution.Methods and resultsTwenty MAs, ten WTs, and nine cases with MA/WT overlapping histological features were studied. Twenty tumors demonstrated the typical morphological spectrum of MA with high cellularity and were composed of tightly packed small, uniform, round acini with a lower Ki67 index. Almost all MAs (94.7%, 18/19) were detected with BRAF V600E mutation. The ten WTs were epithelial-predominant WTs with glands, rosettes and glomerular structures, which also showed a higher Ki-67 index (up to 60%), invasive growth patterns, and a lack of BRAF mutation. However, the other nine overlapping cases showed two components: typical MA-like areas and epithelial WT-like areas. The cells of the WT-like areas were tubular, columnar and showed marked cytological atypia, with a Ki-67 proliferative index of up to 30%. The immunophenotype of these overlapping lesions was not significantly different from that of typical MA and they positively expressed WT1 and CD57. The BRAF V600E mutation was detected in both WT-like and MA-like areas in nine overlapping tumors. The follow-up data of 31 patients were analyzed, with a median follow-up time of 66 months (range, 8-45 months). Even though most patients with WT underwent radiotherapy or chemotherapy after surgery, two died, and one had liver metastasis. No MA or overlapping cases showed any evidence of recurrence or metastasis after surgery.ConclusionsThe molecular changes in tumors with overlapping morphological features were the same as those of typical MA; thus, we think that these tumors should be classified as MA and further called atypical MA. It is important to note that atypical MA is not a neglected subtype of MA. It possesses different histological morphology and a higher Ki-67 index but has the common imaging characteristics, immunophenotype and gene expression as typical MA, and patients usually have a good prognosis.

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Metanephric adenoma: molecular study and review of the literature

Cited by 4 publications

References 18 publications

A giant metanephric adenoma in a young male

A giant metanephric adenoma in a young male

Metanephric adenoma of the kidney: clinical case and literature review

Atypical metanephric adenoma: Shares similar histopathological features and molecular changes of metanephric adenoma and epithelial-predominant Wilms’ tumor

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