Metals for joint replacement

Konttinen, Yrjö T.; Milošev, Ingrid; Trebše, Rihard; Linden, R. van der; Pieper, Jeroen; Sillat, Tarvo; Virtanen, Sannakaisa; Tiainen, Veli‐Matti

doi:10.1533/9780857098474.2.81

Cited by 7 publications

(3 citation statements)

References 135 publications

(100 reference statements)

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“…It is a nonirritative metal, and it has high corrosion resistance. Tantalum shows excellent biocompatibility and good osseointegration on bone and implant interface 186. Ta falls under group V of the periodic table with an elastic modulus of 186 GPa, UTS of 900 MPa, hardness of 200 HV, and density of 16.65 g/cm3 187.…”

mentioning

confidence: 99%

A review on β-Ti alloys for biomedical applications: The influence of alloy composition and thermomechanical processing on mechanical properties, phase composition, and microstructure

Kanapaakala

Sathesh

2022

Proceedings of the Institution of Mechanical Engineers, Part L:

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Titanium and its alloys are potential materials for orthopedic implant applications due to their appropriate biological and mechanical behavior. As biocompatibility and biomechanical compatibilities are essential parameters for determining a biomedical implant's performance and service life, this research review article discussed the novel Ti alloys with nontoxic and biocompatible alloying elements with an elastic modulus similar to the bone. Among Ti alloys, β-Ti alloys are appropriate for load-bearing implant applications due to lower elastic modulus and nontoxic elements, including Ti, Ta, Nb, Zr, Sn, and Mo. Even though the β-Ti alloys possess a lesser elastic modulus compared to other metallic biomaterials, two issues associated with β-Ti alloys that result in implant failure are that they still possess a higher elastic modulus than human bone and they have insufficient strength. Alloy composition and thermomechanical processing characteristics play a vital role in altering the mechanical properties and microstructure of β-Ti alloys. Hence, this review article emphasizes the alloying and thermomechanical processing effects on the mechanical properties and microstructure of β-Ti alloys.

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confidence: 99%

A review on β-Ti alloys for biomedical applications: The influence of alloy composition and thermomechanical processing on mechanical properties, phase composition, and microstructure

Kanapaakala

Sathesh

2022

Proceedings of the Institution of Mechanical Engineers, Part L:

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“…These investigations seek to control cellular activities on the implant surfaces and enhance bone formation, strengthen bone bonding, and confer antibacterial properties. These various modification strategies enable customized responses to specific host environments 1,11–13 …”

Section: Introductionmentioning

confidence: 99%

“…These various modification strategies enable customized responses to specific host environments. 1,[11][12][13] Another commonly used method to achieve functional surfaces that enhance osseointegration is the introduction of bioactive agents, such as extracellular matrix proteins, growth factors, or mineral ions into functional coatings for local release at the tissue-implant interface. This enables active participation of implants in the healing processes.…”

mentioning

confidence: 99%

Locally released dexamethasone and its effects on osteogenic activity at implant‐tissue interface

Kerem,

Önder,

Kılıç

2024

J Biomedical Materials Res

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The osseointegration of titanium implants within the host tissue holds crucial importance. The introduction of functional coatings at tissue—implant interface enhances the bioactivity of titanium implants, improves their therapeutic outcomes, and enhances the effectiveness of treatments. In this study, we focused on enhancing the bioactivity of titanium‐based implant materials by coating the titanium surfaces with chitosan microspheres, which are loaded with osseointegration‐promoting agent dexamethasone (DEX). Initially, chitosan microspheres were successfully produced, followed by DEX loading through diffusion, resulting in a drug loading efficiency of around 50.2 (wt %). The subsequent drug release profile displayed a 24‐hour duration, releasing approximately 32.6 (wt %) of the loaded DEX. In cell proliferation assays using human osteosarcoma (SAOS‐2) cells, Ti surfaces coated with DEX‐loaded chitosan microspheres initially exhibited lower cell numbers compared with DEX‐free ones. This observation was attributed to transient osteogenic differentiation effects of DEX, since a notable increase in cell proliferation was observed on the 7th day. Von Kossa staining revealed mineralization beginning on the 14th day, particularly evident in DEX‐loaded samples. Moreover, alkaline phosphatase (ALP) activity displayed a pattern of initial increase and subsequent decrease, with DEX release from chitosan microspheres showing a clear influence on the osteogenic differentiation, especially on the 7th day. These findings align with literature, highlighting DEX's potential to enhance osteogenic differentiation and cellular behavior on chitosan microsphere‐coated titanium surfaces. This study emphasizes the promising implications for functionalizing surfaces of implant materials with DEX‐loaded chitosan microspheres to improve their biocompatibility and bioactivity.

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Advanced Materials and Three‐dimensional Computer‐aided Surgical Workflow in Cranio‐maxillofacial Reconstruction

González-Pérez

Gonzalez-Perez-Somarriba

Centeno

et al. 2016

Advanced Engineering Materials and Modeling

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Metals for joint replacement

Cited by 7 publications

References 135 publications

A review on β-Ti alloys for biomedical applications: The influence of alloy composition and thermomechanical processing on mechanical properties, phase composition, and microstructure

A review on β-Ti alloys for biomedical applications: The influence of alloy composition and thermomechanical processing on mechanical properties, phase composition, and microstructure

Locally released dexamethasone and its effects on osteogenic activity at implant‐tissue interface

Advanced Materials and Three‐dimensional Computer‐aided Surgical Workflow in Cranio‐maxillofacial Reconstruction

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