Metals as radio-enhancers in oncology: The industry perspective

Pottier, Agnès; Borghi, Elsa; Lévy, Laurent

doi:10.1016/j.bbrc.2015.09.027

Cited by 18 publications

(12 citation statements)

References 18 publications

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“…HfO 2 nanoparticles have been demonstrated as efficient radio-enhancers that could be applicable to most solid tumors 6 , 12 , 49 , 50 . In the future, combination therapy using FU-HfO 2 nanoparticles along with radiotherapy could reduce side effects and enhance the efficacy of treatment for cancer patients.…”

Section: Resultsmentioning

confidence: 99%

A novel approach to low-temperature synthesis of cubic HfO2 nanostructures and their cytotoxicity

Kumar

George

Abrahamse

et al. 2017

Sci Rep

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The development of a strategy to stabilise the cubic phase of HfO2 at lower temperatures is necessary for the emergence of unique properties that are not realised in the thermodynamically stable monoclinic phase. A very high temperature (>2600 °C) is required to produce the cubic phase of HfO2, whereas the monoclinic phase is stable at low temperature. Here, a novel rapid synthesis strategy was designed to develop highly crystalline, pure cubic-phase HfO2 nanoparticles (size <10 nm) using microwave irradiation. Furthermore, the as-prepared nanoparticles were converted to different morphologies (spherical nanoparticles and nanoplates) without compromising the cubic phase by employing a post-hydrothermal treatment in the presence of surface modifiers. The cytotoxicities and proliferative profiles of the synthesised cubic HfO2 nanostructures were investigated over the MCF-7 breast cancer cell line, along with caspase-3/7 activities. The low-temperature phase stabilisation was significantly attributed to surface imperfections (defects and deformations) induced in the crystal lattice by the desirable presence of Na2S·xH2O and NaOH. Our work provides unprecedented insight into the stabilisation of nanoscale cubic-phase HfO2 in ambient environments; the method could be extended to other challenging phases of nanomaterials.

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Section: Resultsmentioning

confidence: 99%

A novel approach to low-temperature synthesis of cubic HfO2 nanostructures and their cytotoxicity

Kumar

George

Abrahamse

et al. 2017

Sci Rep

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“…NBTXR3, the functionalized HfO 2 NPs developed by Nanobiotix ( http://www.nanobiotix.com/_en/ ), are 50-nm-sized crystalline nanoparticles bearing a negative surface charge. NBTXR3 were designed for direct local intratumoral injection and subsequent radiosensitization 6 , 137 . Subsequently, it has been demonstrated by Monte Carlo simulation that NBTXR3 crystalline nanoparticles exposed to high-energy photons could promote a significant radiation dose enhancement, and the obvious radiosensitizing effects of NBTXR3 in vitro and in vivo were presented 138 - 140 .…”

Section: Metal-based Nanoenhancers For Ionizing Ramentioning

confidence: 99%

“…Availability of accredited standards and methodologies for assessing the radiosensitizing and synergistic effects of metal-based NanoEnhancers would enable direct comparison of these investigations undertaken by various groups. Furthermore, the ability of metal-based NanoEnhancers to integrate current clinical principles of radiation oncology, such as administration route and frequency during the course of RT, would determine their acceptance by different stakeholders including physicians and patients 6 .…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…It is of note that high Z (atomic number) materials, especially metals, usually exhibit chemical inertness, which could decrease potential health hazards in cellular and subcellular systems, an attribute that is critical for clinical use 6 . Another factor that can help reduce the side effects of nano-agents is local intratumoral or superselective intra-arterial injection and tumor bed deposition during surgery for localized solid tumors, lowering the volume of distribution.…”

Section: Introductionmentioning

confidence: 99%

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Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

et al. 2018

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Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past decade, there has been growing interest in using high Z (atomic number) elements (materials) as radiosensitizers. New strategies in nanomedicine could help to improve cancer diagnosis and therapy at cellular and molecular levels. Metal-based nanoparticles usually exhibit chemical inertness in cellular and subcellular systems and may play a role in radiosensitization and synergistic cell-killing effects for radiation therapy. This review summarizes the efficacy of metal-based NanoEnhancers against cancers in both in vitro and in vivo systems for a range of ionizing radiations including gamma-rays, X-rays, and charged particles. The potential of translating preclinical studies on metal-based nanoparticles-enhanced radiation therapy into clinical practice is also discussed using examples of several metal-based NanoEnhancers (such as CYT-6091, AGuIX, and NBTXR3). Also, a few general examples of theranostic multimetallic nanocomposites are presented, and the related biological mechanisms are discussed.

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“…However, in recent years, some inorganic nanomaterials have been demonstrated to be promising candidates for the enhancement of cancer radiation treatment. For example, French company Nanobiotix developed a nanoradiosensitizer named NBTXR3, whose effective radiation sensitizing ingredient is HfO 2 nanoparticles . HfO 2 is relatively chemical inert in biological media, which reduce its biotoxicity and encourage its biomedical use.…”

Section: The Clinical Translation Of Nanomaterial‐mediated Tumor Radimentioning

confidence: 99%

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

et al. 2018

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Nano-radiosensitization has been a hot concept for the past ten years, and the nanomaterial-mediated tumor radiosensitization method is mainly focused on increasing intracellular radiation deposition by high atomic number (high Z) nanomaterials, particularly gold (Au)-mediated radiation enhancement. Recently, various new nanomaterial-mediated radiosensitive approaches have been successively reported, such as catalyzing reactive oxygen species (ROS) generation, consuming intracellular reduced glutathione (GSH), overcoming tumor hypoxia, and various synergistic radiotherapy ways. These strategies may open a new avenue for enhancing the radiotherapeutic effect and avoiding its side effects. Nevertheless, reviews systematically summarizing these newly emerging methods and their radiosensitive mechanisms are still rare. Therefore, the general strategies of nanomaterial-mediated tumor radiosensitization are comprehensively summarized, particularly aiming at introducing the emerging radiosensitive methods. The strategies are divided into three general parts. First, methods on account of the intrinsic radiosensitive properties of nanoradiosensitizers for radiosensitization are highlighted. Then, newly developed synergistic strategies based on multifunctional nanomaterials for enhancing radiotherapy efficacy are emphasized. Third, nanomaterial-mediated radioprotection approaches for increasing the radiotherapeutic ratio are discussed. Importantly, the clinical translation of nanomaterial-mediated tumor radiosensitization is also covered. Finally, further challenges and outlooks in this field are discussed.

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Metals as radio-enhancers in oncology: The industry perspective

Cited by 18 publications

References 18 publications

A novel approach to low-temperature synthesis of cubic HfO2 nanostructures and their cytotoxicity

A novel approach to low-temperature synthesis of cubic HfO2 nanostructures and their cytotoxicity

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

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