Metals and the respiratory tract

Nemery, Benoît

doi:10.1016/b978-0-12-823292-7.00030-9

Cited by 6 publications

(5 citation statements)

References 217 publications

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“…The toxicity of metal particles has already been studied for different metals that may contaminate at the work place [ 32 , 33 , 34 ]. Nevertheless, this work is the first one on the impact of accidental inhalation of tritiated steel and cement particles.…”

Section: Discussionmentioning

confidence: 99%

Cyto-Genotoxicity of Tritiated Stainless Steel and Cement Particles in Human Lung Cell Models

Lamartinière¹,

Slomberg

Payet

et al. 2022

IJMS

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During the decommissioning of nuclear facilities, the tritiated materials must be removed. These operations generate tritiated steel and cement particles that could be accidentally inhaled by workers. Thus, the consequences of human exposure by inhalation to these particles in terms of radiotoxicology were investigated. Their cyto-genotoxicity was studied using two human lung models: the BEAS-2B cell line and the 3D MucilAirTM model. Exposures of the BEAS-2B cell line to particles (2 and 24 h) did not induce significant cytotoxicity. Nevertheless, DNA damage occurred upon exposure to tritiated and non-tritiated particles, as observed by alkaline comet assay. Tritiated particles only induced cytostasis; however, both induced a significant increase in centromere negative micronuclei. Particles were also assessed for their effects on epithelial integrity and metabolic activity using the MucilAirTM model in a 14-day kinetic mode. No effect was noted. Tritium transfer through the epithelium was observed without intracellular accumulation. Overall, tritiated and non-tritiated stainless steel and cement particles were associated with moderate toxicity. However, these particles induce DNA lesions and chromosome breakage to which tritium seems to contribute. These data should help in a better management of the risk related to the inhalation of these types of particles.

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Section: Discussionmentioning

confidence: 99%

Cyto-Genotoxicity of Tritiated Stainless Steel and Cement Particles in Human Lung Cell Models

Lamartinière¹,

Slomberg

Payet

et al. 2022

IJMS

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“…Metallic dust deposited in the lung may give rise to various types of lung disease. 29 One example is chronic beryllium disease, a lung disease in which susceptible individuals develop an immunological response to (sometimes relatively low levels of) inhaled beryllium. Chronic beryllium disease is well-known for its striking histologic and clinical resemblance to sarcoidosis.…”

Section: ■ Introductionmentioning

confidence: 99%

“…To delve more precisely into our subject of research, we will thus focus on occupational exposures to metallic dust, which can be encountered in miners, metallurgists, jewelers, and workers in metal recycling, to name just a few examples. Metallic dust deposited in the lung may give rise to various types of lung disease . One example is chronic beryllium disease, a lung disease in which susceptible individuals develop an immunological response to (sometimes relatively low levels of) inhaled beryllium.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Diagnostic Capabilities for Occupational Lung Diseases Using LIBS Imaging on Biopsy Tissue

Ferreira,

Gardette,

Busser

et al. 2024

Anal. Chem.

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Laser-induced breakdown spectroscopy (LIBS) imaging continues to gain strength as an influential bioanalytical technique, showing intriguing potential in the field of clinical analysis. This is because hyperspectral LIBS imaging allows for rapid, comprehensive elemental analysis, covering elements from major to trace levels consistently year after year. In this study, we estimated the potential of a multivariate spectral data treatment approach based on a so-called convex envelope method to detect exotic elements (whether they are minor or in trace amounts) in biopsy tissues of patients with occupational exposure-related diseases. More precisely, we have developed an approach called Interesting Features Finder (IFF), which initially allowed us to identify unexpected elements without any preconceptions, considering only the set of spectra contained in a LIBS hyperspectral data cube. This task is, in fact, almost impossible with conventional chemometric tools, as it entails identifying a few exotic spectra among several hundred thousand others. Once this detection was performed, a second approach based on correlation was used to locate their distribution in the biopsies. Through this unique data analysis pipeline to processing massive LIBS spectroscopic data, it was possible to detect and locate exotic elements such as tin and rhodium in a patient's tissue section, ultimately leading to a possible reclassification of their lung condition as an occupational disease. This review will thus demonstrate the potential of this new diagnostic tool based on LIBS imaging in addressing the shortcomings of approaches developed thus far. The proposed data processing approach naturally transcends this specific framework and can be leveraged across various domains of analytical chemistry, where the detection of rare events is concealed within extensive data sets.

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“…It finds application in making ceramic cutlery 7 . However, excessive exposure to zirconium can be harmful, posing danger to health issues including lung and pulmonary granulomas, tissue inflammation, skin irritation and genotoxic effects 8–10 . The Occupational Safety and Health Administration (OSHA) in the United States has established that the acceptable limit of exposure to zirconium is 5 mg/m 3 during an 8‐h workday, and at a concentration of 25 mg/m 3 , zirconium poses an immediate threat to life and health 11 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Schiff base functionalized organosilatranes for the detection of Zirconium (IV) ion: Their cytotoxicity evaluation and anti‐inflammatory activity against cyclooxygenase‐2 via computational approach

Singh,

Thakur,

Mithun

et al. 2023

Applied Organom Chemis

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Zirconium, a transition metal with medical importance, is widely used and has a generally safe profile. However, prolonged and continuous exposure can lead to detrimental consequences; this necessitates the development of quick and efficient sensors for the detection of Zr(IV) ion. The current investigation focuses on the synthesis and characterization of 4‐(methylthio)benzaldehyde derived Schiff base functionalized organosilatranes (2a–2b). The probe 2a has been utilized as a UV–visible absorption based, highly selective and sensitive sensor for the detection of Zr(IV) ion with a limit of detection and association constant values of 10.89 × 10−7 M and 3.1 × 104 M−1, respectively. The practical applicability of the synthesized sensor has been determined in water samples, yielding good percentage recovery rates. The cytotoxicity assay has been performed using SAF‐1 cell line, rendering the synthesized compounds non‐toxic. Furthermore, molecular docking has been performed against cyclooxygenase‐2 in order to determine anti‐inflammatory activity of synthesized ligand with a binding energy score of −7.51 kcal mol−1.

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Metals and the respiratory tract

Cited by 6 publications

References 217 publications

Cyto-Genotoxicity of Tritiated Stainless Steel and Cement Particles in Human Lung Cell Models

Cyto-Genotoxicity of Tritiated Stainless Steel and Cement Particles in Human Lung Cell Models

Enhancing Diagnostic Capabilities for Occupational Lung Diseases Using LIBS Imaging on Biopsy Tissue

Synthesis of Schiff base functionalized organosilatranes for the detection of Zirconium (IV) ion: Their cytotoxicity evaluation and anti‐inflammatory activity against cyclooxygenase‐2 via computational approach

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